KRAS inhibition reverses chemotherapy resistance promoted by therapy-induced senescence-like in pancreatic ductal adenocarcinoma

KRAS inhibition reverses chemotherapy resistance promoted by therapy-induced senescence-like in pancreatic ductal adenocarcinoma

Background: Emerging evidence suggests that chemotherapy can accumulate senescent-like cells within tumor tissues, a phenomenon linked to therapy resistance. The aim of this study is to analyze the senescence-like state of after-treatment persistent cells associated with KRAS mutational status to of...

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Bibliographic Details
Main Authors: Analia Meilerman Abuelafia, Patricia Santofimia-Castaño, Matias Estaras, Daniel Grasso, Eduardo Chuluyan, Gwen Lomberk, Raul Urrutia, Nelson Dusetti, Nicolas Fraunhoffer, Juan Iovanna
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Translational Oncology
Subjects:
PDAC
Senescence-like
Mutated KRAS
MRTX1133
Gemcitabine
Resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001524
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