The hierarchical folding dynamics of topologically associating domains during early embryo development

The hierarchical folding dynamics of topologically associating domains during early embryo development

Abstract Background Recent research has indicated a close connection between the three-dimensional (3D) structure of chromatin and early embryo development, with precise higher-order chromatin folding playing a significant role in mediating gene expression. However, the specific role of 3D genomic h...

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Bibliographic Details
Main Authors: Xuemei Bai, Xiaohan Tang, Yuyang Wang, Shutong Yue, Xiang Xu, Pengzhen Hu, Jingxuan Xu, Yaru Li, Junting Wang, Huan Tao, Yang Zheng, Bijia Chen, Mengge Tian, Lin Lin, Ruiqing Wang, Yu Sun, Chao Ren, Xiaochen Bo, Hao Li, Hebing Chen, Meisong Lu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Biology
Subjects:
Early embryo
Hi-C
Hierarchical TAD
Deep neural network
Online Access:https://doi.org/10.1186/s12915-025-02259-y
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