EGFR T790M-Positive Lung Adenocarcinoma Metastases to the Pituitary Gland Causing Adrenal Insufficiency: A Case Report
A 64-year-old man, with history of micropapillary thyroid cancer and epidermal growth factor receptor-positive lung adenocarcinoma with no evidence of active disease for 3 years after chemotherapy and radiation on erlotinib, presented with fatigue, nausea, lack of appetite, and xeroderma. A screenin...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/2349021 |
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| author | Michael L. Adashek Kenneth Miller Arit A. Silpasuvan |
| author_facet | Michael L. Adashek Kenneth Miller Arit A. Silpasuvan |
| author_sort | Michael L. Adashek |
| collection | DOAJ |
| description | A 64-year-old man, with history of micropapillary thyroid cancer and epidermal growth factor receptor-positive lung adenocarcinoma with no evidence of active disease for 3 years after chemotherapy and radiation on erlotinib, presented with fatigue, nausea, lack of appetite, and xeroderma. A screening magnetic resonance image of the patient’s head demonstrated a new bilateral pituitary mass. Initial evaluation revealed low morning cortisol, and the patient was diagnosed with adrenal insufficiency. His symptoms rapidly improved with maintenance glucocorticoids. Soon thereafter, the patient developed an acute visual deficit secondary to enlargement of the pituitary mass, and biopsy revealed EGFR T790M positive metastatic lung adenocarcinoma. Hence, we present a rare case of metastatic lung adenocarcinoma to the pituitary causing secondary adrenal insufficiency. |
| format | Article |
| id | doaj-art-44fcb96aef4e48948006023b8659da49 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-44fcb96aef4e48948006023b8659da492025-02-03T01:24:34ZengWileyCase Reports in Oncological Medicine2090-67062090-67142018-01-01201810.1155/2018/23490212349021EGFR T790M-Positive Lung Adenocarcinoma Metastases to the Pituitary Gland Causing Adrenal Insufficiency: A Case ReportMichael L. Adashek0Kenneth Miller1Arit A. Silpasuvan2Department of Internal Medicine, Sinai Hospital, Baltimore, MD, USAUniversity of Maryland Marlene & Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USADepartment of Endocrinology, Sinai Hospital, Baltimore, MD, USAA 64-year-old man, with history of micropapillary thyroid cancer and epidermal growth factor receptor-positive lung adenocarcinoma with no evidence of active disease for 3 years after chemotherapy and radiation on erlotinib, presented with fatigue, nausea, lack of appetite, and xeroderma. A screening magnetic resonance image of the patient’s head demonstrated a new bilateral pituitary mass. Initial evaluation revealed low morning cortisol, and the patient was diagnosed with adrenal insufficiency. His symptoms rapidly improved with maintenance glucocorticoids. Soon thereafter, the patient developed an acute visual deficit secondary to enlargement of the pituitary mass, and biopsy revealed EGFR T790M positive metastatic lung adenocarcinoma. Hence, we present a rare case of metastatic lung adenocarcinoma to the pituitary causing secondary adrenal insufficiency.http://dx.doi.org/10.1155/2018/2349021 |
| spellingShingle | Michael L. Adashek Kenneth Miller Arit A. Silpasuvan EGFR T790M-Positive Lung Adenocarcinoma Metastases to the Pituitary Gland Causing Adrenal Insufficiency: A Case Report Case Reports in Oncological Medicine |
| title | EGFR T790M-Positive Lung Adenocarcinoma Metastases to the Pituitary Gland Causing Adrenal Insufficiency: A Case Report |
| title_full | EGFR T790M-Positive Lung Adenocarcinoma Metastases to the Pituitary Gland Causing Adrenal Insufficiency: A Case Report |
| title_fullStr | EGFR T790M-Positive Lung Adenocarcinoma Metastases to the Pituitary Gland Causing Adrenal Insufficiency: A Case Report |
| title_full_unstemmed | EGFR T790M-Positive Lung Adenocarcinoma Metastases to the Pituitary Gland Causing Adrenal Insufficiency: A Case Report |
| title_short | EGFR T790M-Positive Lung Adenocarcinoma Metastases to the Pituitary Gland Causing Adrenal Insufficiency: A Case Report |
| title_sort | egfr t790m positive lung adenocarcinoma metastases to the pituitary gland causing adrenal insufficiency a case report |
| url | http://dx.doi.org/10.1155/2018/2349021 |
| work_keys_str_mv | AT michaelladashek egfrt790mpositivelungadenocarcinomametastasestothepituitaryglandcausingadrenalinsufficiencyacasereport AT kennethmiller egfrt790mpositivelungadenocarcinomametastasestothepituitaryglandcausingadrenalinsufficiencyacasereport AT aritasilpasuvan egfrt790mpositivelungadenocarcinomametastasestothepituitaryglandcausingadrenalinsufficiencyacasereport |