Hyperreflective Dots in Central Fovea Visualized by a Novel Application of Visible-Light Optical Coherence Tomography
Visible-light optical coherence tomography (vis-OCT) is a novel noninvasive retinal imaging system that offers improved resolution compared to conventional near-infrared (NIR) OCT systems. Here, we utilized vis-OCT to produce fibergrams (vis-OCTF) for the first time in human patients, enabling en fa...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Ophthalmological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2024/5823455 |
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| author | Michael A. Krause Marta Grannonico Brooke P. Tyler David A. Miller Weijia Fan Mingna Liu Roman V. Kuranov Hao F. Zhang Xiaorong Liu Peter A. Netland |
| author_facet | Michael A. Krause Marta Grannonico Brooke P. Tyler David A. Miller Weijia Fan Mingna Liu Roman V. Kuranov Hao F. Zhang Xiaorong Liu Peter A. Netland |
| author_sort | Michael A. Krause |
| collection | DOAJ |
| description | Visible-light optical coherence tomography (vis-OCT) is a novel noninvasive retinal imaging system that offers improved resolution compared to conventional near-infrared (NIR) OCT systems. Here, we utilized vis-OCT to produce fibergrams (vis-OCTF) for the first time in human patients, enabling en face visualization and precise quantification of hyperreflective dots in the central fovea in two patients. We also directly compare the imaging qualities of conventional vis-OCT and NIR-OCT. Vis-OCT generated a 3×3 mm2en face image with an impressive axial resolution of 1.3 μm, whereas NIR-OCT produced an en face image with a larger field of view (FOV) (9×9 mm2) but a lower resolution of 7.0 μm. Moreover, vis-OCTF unveiled clear images of hyperreflective dots in the fovea of both patients, which were not discernible in the NIR-OCT en face images. Foveal dots have often been linked to several age-related and pathological conditions. The high-resolution images generated by vis-OCTF enable more precise characterization of changes in retinal sublayers within the central fovea. |
| format | Article |
| id | doaj-art-44dc4605d19240869fd155108ca5c46d |
| institution | Kabale University |
| issn | 2090-6730 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Ophthalmological Medicine |
| spelling | doaj-art-44dc4605d19240869fd155108ca5c46d2025-02-03T07:23:46ZengWileyCase Reports in Ophthalmological Medicine2090-67302024-01-01202410.1155/2024/5823455Hyperreflective Dots in Central Fovea Visualized by a Novel Application of Visible-Light Optical Coherence TomographyMichael A. Krause0Marta Grannonico1Brooke P. Tyler2David A. Miller3Weijia Fan4Mingna Liu5Roman V. Kuranov6Hao F. Zhang7Xiaorong Liu8Peter A. Netland9Department of OphthalmologyDepartment of BiologyDepartment of OphthalmologyDepartment of Biomedical EngineeringDepartment of Biomedical EngineeringDepartment of BiologyDepartment of Biomedical EngineeringDepartment of Biomedical EngineeringDepartment of OphthalmologyDepartment of OphthalmologyVisible-light optical coherence tomography (vis-OCT) is a novel noninvasive retinal imaging system that offers improved resolution compared to conventional near-infrared (NIR) OCT systems. Here, we utilized vis-OCT to produce fibergrams (vis-OCTF) for the first time in human patients, enabling en face visualization and precise quantification of hyperreflective dots in the central fovea in two patients. We also directly compare the imaging qualities of conventional vis-OCT and NIR-OCT. Vis-OCT generated a 3×3 mm2en face image with an impressive axial resolution of 1.3 μm, whereas NIR-OCT produced an en face image with a larger field of view (FOV) (9×9 mm2) but a lower resolution of 7.0 μm. Moreover, vis-OCTF unveiled clear images of hyperreflective dots in the fovea of both patients, which were not discernible in the NIR-OCT en face images. Foveal dots have often been linked to several age-related and pathological conditions. The high-resolution images generated by vis-OCTF enable more precise characterization of changes in retinal sublayers within the central fovea.http://dx.doi.org/10.1155/2024/5823455 |
| spellingShingle | Michael A. Krause Marta Grannonico Brooke P. Tyler David A. Miller Weijia Fan Mingna Liu Roman V. Kuranov Hao F. Zhang Xiaorong Liu Peter A. Netland Hyperreflective Dots in Central Fovea Visualized by a Novel Application of Visible-Light Optical Coherence Tomography Case Reports in Ophthalmological Medicine |
| title | Hyperreflective Dots in Central Fovea Visualized by a Novel Application of Visible-Light Optical Coherence Tomography |
| title_full | Hyperreflective Dots in Central Fovea Visualized by a Novel Application of Visible-Light Optical Coherence Tomography |
| title_fullStr | Hyperreflective Dots in Central Fovea Visualized by a Novel Application of Visible-Light Optical Coherence Tomography |
| title_full_unstemmed | Hyperreflective Dots in Central Fovea Visualized by a Novel Application of Visible-Light Optical Coherence Tomography |
| title_short | Hyperreflective Dots in Central Fovea Visualized by a Novel Application of Visible-Light Optical Coherence Tomography |
| title_sort | hyperreflective dots in central fovea visualized by a novel application of visible light optical coherence tomography |
| url | http://dx.doi.org/10.1155/2024/5823455 |
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