Seventh-Day Syndrome after liver transplantation in a patient with hepatocellular carcinoma
Background. Seventh-Day Syndrome following liver transplantation is a rare but serious complication characterized by a sudden deterioration of the graft function after initial normalization, often leading to death. The peak occurrence of this syndrome is in the late first or early second week post-t...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2025-04-01
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| Series: | Трансплантология (Москва) |
| Subjects: | |
| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/963 |
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| Summary: | Background. Seventh-Day Syndrome following liver transplantation is a rare but serious complication characterized by a sudden deterioration of the graft function after initial normalization, often leading to death. The peak occurrence of this syndrome is in the late first or early second week post-transplant. Currently, there are no established treatment standards for Seventh-Day Syndrome, and its natural course usually results in a graft loss.Objective. To present a clinical case of Seventh-Day Syndrome after liver transplantation and analyze strategies for early diagnosis and treatment.Results. A patient who underwent liver transplantation for viral cirrhosis and hepatocellular carcinoma was diagnosed with Seventh-Day Syndrome on the eighth day post-surgery, which was accompanied by acute deterioration in the graft function and the development of fulminant liver failure. Despite a timely diagnosis and immediate treatment, including high doses of methylprednisolone, immunoglobulin administration, and plasmapheresis, the patient's condition persistently worsened, resulting in death on postoperative day 11.Conclusion. Despite a timely diagnosis and treatment, the prognosis for Seventh-Day Syndrome remains poor, underscoring the need for further research. |
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| ISSN: | 2074-0506 2542-0909 |