An Update on the Changing Indications for Androgen Deprivation Therapy for Prostate Cancer
Quality of life has become increasingly more important for men diagnosed with prostate cancer. In light of this and the recognized risks of androgen deprivation therapy (ADT), the guidelines and use of ADT have changed significantly over the last few years. This paper reviews the current recommendat...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2011/419174 |
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| _version_ | 1832567645833003008 |
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| author | Kristene Myklak Shandra Wilson |
| author_facet | Kristene Myklak Shandra Wilson |
| author_sort | Kristene Myklak |
| collection | DOAJ |
| description | Quality of life has become increasingly more important for men diagnosed with prostate cancer. In light of this and the recognized risks of androgen deprivation therapy (ADT), the guidelines and use of ADT have changed significantly over the last few years. This paper reviews the current recommendations and the future perspectives regarding ADT. The benefits of ADT are evident neoadjuvantly and adjuvantly in patients treated with external beam radiation therapy for intermediate- and high-risk disease, in patients who have undergone prostatectomy with lymph node involvement, in high-risk patients after definitive therapy, and in patients who have developed progression or metastasis. Finally, this paper reviews the risks and benefits of each of these scenarios and the risks of androgen deprivation in general, and it delineates the areas where ADT was previously recommended, but where evidence is lacking for its additional benefit. |
| format | Article |
| id | doaj-art-44bb8bb99a3e442b9324effd6655af53 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-44bb8bb99a3e442b9324effd6655af532025-02-03T01:00:54ZengWileyProstate Cancer2090-31112090-312X2011-01-01201110.1155/2011/419174419174An Update on the Changing Indications for Androgen Deprivation Therapy for Prostate CancerKristene Myklak0Shandra Wilson1Division of Urology, Department of Surgery, University of Colorado Denver, Aurora, CO 80045, USADivision of Urology, Department of Surgery, University of Colorado Denver, Aurora, CO 80045, USAQuality of life has become increasingly more important for men diagnosed with prostate cancer. In light of this and the recognized risks of androgen deprivation therapy (ADT), the guidelines and use of ADT have changed significantly over the last few years. This paper reviews the current recommendations and the future perspectives regarding ADT. The benefits of ADT are evident neoadjuvantly and adjuvantly in patients treated with external beam radiation therapy for intermediate- and high-risk disease, in patients who have undergone prostatectomy with lymph node involvement, in high-risk patients after definitive therapy, and in patients who have developed progression or metastasis. Finally, this paper reviews the risks and benefits of each of these scenarios and the risks of androgen deprivation in general, and it delineates the areas where ADT was previously recommended, but where evidence is lacking for its additional benefit.http://dx.doi.org/10.1155/2011/419174 |
| spellingShingle | Kristene Myklak Shandra Wilson An Update on the Changing Indications for Androgen Deprivation Therapy for Prostate Cancer Prostate Cancer |
| title | An Update on the Changing Indications for Androgen Deprivation Therapy for Prostate Cancer |
| title_full | An Update on the Changing Indications for Androgen Deprivation Therapy for Prostate Cancer |
| title_fullStr | An Update on the Changing Indications for Androgen Deprivation Therapy for Prostate Cancer |
| title_full_unstemmed | An Update on the Changing Indications for Androgen Deprivation Therapy for Prostate Cancer |
| title_short | An Update on the Changing Indications for Androgen Deprivation Therapy for Prostate Cancer |
| title_sort | update on the changing indications for androgen deprivation therapy for prostate cancer |
| url | http://dx.doi.org/10.1155/2011/419174 |
| work_keys_str_mv | AT kristenemyklak anupdateonthechangingindicationsforandrogendeprivationtherapyforprostatecancer AT shandrawilson anupdateonthechangingindicationsforandrogendeprivationtherapyforprostatecancer AT kristenemyklak updateonthechangingindicationsforandrogendeprivationtherapyforprostatecancer AT shandrawilson updateonthechangingindicationsforandrogendeprivationtherapyforprostatecancer |