Diabetes in HFE Hemochromatosis
Diabetes in whites of European descent with hemochromatosis was first attributed to pancreatic siderosis. Later observations revealed that the pathogenesis of diabetes in HFE hemochromatosis is multifactorial and its clinical manifestations are heterogeneous. Increased type 2 diabetes risk in HFE he...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/9826930 |
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| author | James C. Barton Ronald T. Acton |
| author_facet | James C. Barton Ronald T. Acton |
| author_sort | James C. Barton |
| collection | DOAJ |
| description | Diabetes in whites of European descent with hemochromatosis was first attributed to pancreatic siderosis. Later observations revealed that the pathogenesis of diabetes in HFE hemochromatosis is multifactorial and its clinical manifestations are heterogeneous. Increased type 2 diabetes risk in HFE hemochromatosis is associated with one or more factors, including abnormal iron homeostasis and iron overload, decreased insulin secretion, cirrhosis, diabetes in first-degree relatives, increased body mass index, insulin resistance, and metabolic syndrome. In p.C282Y homozygotes, serum ferritin, usually elevated at hemochromatosis diagnosis, largely reflects body iron stores but not diabetes risk. In persons with diabetes type 2 without hemochromatosis diagnoses, serum ferritin levels are higher than those of persons without diabetes, but most values are within the reference range. Phlebotomy therapy to achieve iron depletion does not improve diabetes control in all persons with HFE hemochromatosis. The prevalence of type 2 diabetes diagnosed today in whites of European descent with and without HFE hemochromatosis is similar. Routine iron phenotyping or HFE genotyping of patients with type 2 diabetes is not recommended. Herein, we review diabetes in HFE hemochromatosis and the role of iron in diabetes pathogenesis in whites of European descent with and without HFE hemochromatosis. |
| format | Article |
| id | doaj-art-44b2bef2eeaf4c1abcd566be2349ab52 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-44b2bef2eeaf4c1abcd566be2349ab522025-02-03T01:28:45ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/98269309826930Diabetes in HFE HemochromatosisJames C. Barton0Ronald T. Acton1Southern Iron Disorders Center, Birmingham, AL 35209, USASouthern Iron Disorders Center, Birmingham, AL 35209, USADiabetes in whites of European descent with hemochromatosis was first attributed to pancreatic siderosis. Later observations revealed that the pathogenesis of diabetes in HFE hemochromatosis is multifactorial and its clinical manifestations are heterogeneous. Increased type 2 diabetes risk in HFE hemochromatosis is associated with one or more factors, including abnormal iron homeostasis and iron overload, decreased insulin secretion, cirrhosis, diabetes in first-degree relatives, increased body mass index, insulin resistance, and metabolic syndrome. In p.C282Y homozygotes, serum ferritin, usually elevated at hemochromatosis diagnosis, largely reflects body iron stores but not diabetes risk. In persons with diabetes type 2 without hemochromatosis diagnoses, serum ferritin levels are higher than those of persons without diabetes, but most values are within the reference range. Phlebotomy therapy to achieve iron depletion does not improve diabetes control in all persons with HFE hemochromatosis. The prevalence of type 2 diabetes diagnosed today in whites of European descent with and without HFE hemochromatosis is similar. Routine iron phenotyping or HFE genotyping of patients with type 2 diabetes is not recommended. Herein, we review diabetes in HFE hemochromatosis and the role of iron in diabetes pathogenesis in whites of European descent with and without HFE hemochromatosis.http://dx.doi.org/10.1155/2017/9826930 |
| spellingShingle | James C. Barton Ronald T. Acton Diabetes in HFE Hemochromatosis Journal of Diabetes Research |
| title | Diabetes in HFE Hemochromatosis |
| title_full | Diabetes in HFE Hemochromatosis |
| title_fullStr | Diabetes in HFE Hemochromatosis |
| title_full_unstemmed | Diabetes in HFE Hemochromatosis |
| title_short | Diabetes in HFE Hemochromatosis |
| title_sort | diabetes in hfe hemochromatosis |
| url | http://dx.doi.org/10.1155/2017/9826930 |
| work_keys_str_mv | AT jamescbarton diabetesinhfehemochromatosis AT ronaldtacton diabetesinhfehemochromatosis |