Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study
Acinic cell carcinoma of the breast is an extremely rare, malignant neoplasm characterized by widespread acinar cell-like differentiation and clinically low-grade malignancy. Herein, we report a case of acinic cell carcinoma of the breast in a 41-year-old woman. The tumor was poorly demarcated but h...
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Wiley
2013-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/372947 |
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| author | Kiyoshi Shingu Tokiko Ito Gengo Kaneko Nobuo Itoh |
| author_facet | Kiyoshi Shingu Tokiko Ito Gengo Kaneko Nobuo Itoh |
| author_sort | Kiyoshi Shingu |
| collection | DOAJ |
| description | Acinic cell carcinoma of the breast is an extremely rare, malignant neoplasm characterized by widespread acinar cell-like differentiation and clinically low-grade malignancy. Herein, we report a case of acinic cell carcinoma of the breast in a 41-year-old woman. The tumor was poorly demarcated but had a firm consistency. It was removed with lumpectomy, and sentinel lymph node biopsy was performed to check for metastasis. Microscopically, the tumor showed an infiltrative growth pattern with a combination of solid, trabecular, and microglandular areas. Many of the tumor cells had abundant clear vacuolated cytoplasm containing zymogen-typed granules which resemble acinar cells of the salivary glands. The immunohistochemical profile of the tumor was also similar to that of salivary gland acinic cell carcinoma: the tumor cells were positive for amylase, lysozyme, α-1-antichymotrypsin, S-100 protein, and epithelial membrane antigen and negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. She received postoperative chemoradiation therapy and has been well for 3 years since surgery. As studies on large series are lacking, further studies are needed to elucidate the biological characteristics of acinic cell carcinoma of the breast. |
| format | Article |
| id | doaj-art-4494139781e342ea8d71773a2c822e50 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
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| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-4494139781e342ea8d71773a2c822e502025-02-03T06:42:15ZengWileyCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/372947372947Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical StudyKiyoshi Shingu0Tokiko Ito1Gengo Kaneko2Nobuo Itoh3Departments of Surgery and Pathology, Iida Municipal Hospital, 438 Yawatacho, Iida, Nagano 395-8502, JapanDepartments of Surgery and Pathology, Iida Municipal Hospital, 438 Yawatacho, Iida, Nagano 395-8502, JapanDepartments of Surgery and Pathology, Iida Municipal Hospital, 438 Yawatacho, Iida, Nagano 395-8502, JapanDepartments of Surgery and Pathology, Iida Municipal Hospital, 438 Yawatacho, Iida, Nagano 395-8502, JapanAcinic cell carcinoma of the breast is an extremely rare, malignant neoplasm characterized by widespread acinar cell-like differentiation and clinically low-grade malignancy. Herein, we report a case of acinic cell carcinoma of the breast in a 41-year-old woman. The tumor was poorly demarcated but had a firm consistency. It was removed with lumpectomy, and sentinel lymph node biopsy was performed to check for metastasis. Microscopically, the tumor showed an infiltrative growth pattern with a combination of solid, trabecular, and microglandular areas. Many of the tumor cells had abundant clear vacuolated cytoplasm containing zymogen-typed granules which resemble acinar cells of the salivary glands. The immunohistochemical profile of the tumor was also similar to that of salivary gland acinic cell carcinoma: the tumor cells were positive for amylase, lysozyme, α-1-antichymotrypsin, S-100 protein, and epithelial membrane antigen and negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. She received postoperative chemoradiation therapy and has been well for 3 years since surgery. As studies on large series are lacking, further studies are needed to elucidate the biological characteristics of acinic cell carcinoma of the breast.http://dx.doi.org/10.1155/2013/372947 |
| spellingShingle | Kiyoshi Shingu Tokiko Ito Gengo Kaneko Nobuo Itoh Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study Case Reports in Oncological Medicine |
| title | Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study |
| title_full | Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study |
| title_fullStr | Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study |
| title_full_unstemmed | Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study |
| title_short | Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study |
| title_sort | primary acinic cell carcinoma of the breast a clinicopathological and immunohistochemical study |
| url | http://dx.doi.org/10.1155/2013/372947 |
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