Rabs, Rips, FIPs, and Endocytic Membrane Traffic
Rab GTPases, proteins belonging to the Ras-like small GTP-binding protein superfamily, have emerged as master regulators of cellular membrane transport. Rab11 GTPase, a member of the Rab protein family, plays a role in regulating various cellular functions, including plasma membrane recycling, phago...
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2003.69 |
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| _version_ | 1832567581651763200 |
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| author | Rytis Prekeris |
| author_facet | Rytis Prekeris |
| author_sort | Rytis Prekeris |
| collection | DOAJ |
| description | Rab GTPases, proteins belonging to the Ras-like small GTP-binding protein superfamily, have emerged as master regulators of cellular membrane transport. Rab11 GTPase, a member of the Rab protein family, plays a role in regulating various cellular functions, including plasma membrane recycling, phagocytosis, and cytokinesis. Rab11 acts by forming mutually exclusive complexes with Rab11-family binding proteins, known as FIPs. Rab11-FIP complexes serve a role of �targeting complexes� by recruiting various membrane traffic factors to cellular membranes. Recent studies have identified several Rab11-FIP complex-binding proteins that regulate distinct membrane traffic pathways. |
| format | Article |
| id | doaj-art-4491df2d462e4381b34609eab9d8366a |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-4491df2d462e4381b34609eab9d8366a2025-02-03T01:01:00ZengWileyThe Scientific World Journal1537-744X2003-01-01387088010.1100/tsw.2003.69Rabs, Rips, FIPs, and Endocytic Membrane TrafficRytis Prekeris0Department of Cellular and Structural Biology, School of Medicine, University of Colorado Health Sciences Center, 4200 E. Ninth Ave., Room 4520, B-111, Denver, CO 80262, USARab GTPases, proteins belonging to the Ras-like small GTP-binding protein superfamily, have emerged as master regulators of cellular membrane transport. Rab11 GTPase, a member of the Rab protein family, plays a role in regulating various cellular functions, including plasma membrane recycling, phagocytosis, and cytokinesis. Rab11 acts by forming mutually exclusive complexes with Rab11-family binding proteins, known as FIPs. Rab11-FIP complexes serve a role of �targeting complexes� by recruiting various membrane traffic factors to cellular membranes. Recent studies have identified several Rab11-FIP complex-binding proteins that regulate distinct membrane traffic pathways.http://dx.doi.org/10.1100/tsw.2003.69 |
| spellingShingle | Rytis Prekeris Rabs, Rips, FIPs, and Endocytic Membrane Traffic The Scientific World Journal |
| title | Rabs, Rips, FIPs, and Endocytic Membrane Traffic |
| title_full | Rabs, Rips, FIPs, and Endocytic Membrane Traffic |
| title_fullStr | Rabs, Rips, FIPs, and Endocytic Membrane Traffic |
| title_full_unstemmed | Rabs, Rips, FIPs, and Endocytic Membrane Traffic |
| title_short | Rabs, Rips, FIPs, and Endocytic Membrane Traffic |
| title_sort | rabs rips fips and endocytic membrane traffic |
| url | http://dx.doi.org/10.1100/tsw.2003.69 |
| work_keys_str_mv | AT rytisprekeris rabsripsfipsandendocyticmembranetraffic |