Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris
Background. Psoriasis vulgaris is a chronic autoimmune disease associated with systemic inflammation. Increased levels of numerous cytokines, chemokines, growth factors, and other molecules were found in the skin and in the circulation of psoriatic patients. Alarmins, also known as danger signals, a...
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| Format: | Article |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/8465083 |
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| author | Pavel Borsky Zdenek Fiala Ctirad Andrys Martin Beranek Kvetoslava Hamakova Andrea Malkova Tereza Svadlakova Jan Krejsek Vladimir Palicka Lenka Borska Vit Rehacek |
| author_facet | Pavel Borsky Zdenek Fiala Ctirad Andrys Martin Beranek Kvetoslava Hamakova Andrea Malkova Tereza Svadlakova Jan Krejsek Vladimir Palicka Lenka Borska Vit Rehacek |
| author_sort | Pavel Borsky |
| collection | DOAJ |
| description | Background. Psoriasis vulgaris is a chronic autoimmune disease associated with systemic inflammation. Increased levels of numerous cytokines, chemokines, growth factors, and other molecules were found in the skin and in the circulation of psoriatic patients. Alarmins, also known as danger signals, are intracellular proteins, which are released to an extracellular space after infection or damage. They are the markers of cell destructive processes. Objective. The aim of the present study was to evaluate the suitability of selected alarmins (HMGB1, IL-33, S100A7, and S100A12) as potential biomarkers of severity of psoriasis and to explore possible relationships between these proteins for the purpose of better understanding their roles in the immunopathology of psoriasis. Methods. The serum levels of selected alarmins were measured in 63 psoriatic patients and 95 control individuals. The levels were assessed by the ELISA technique using commercial kits. The data were statistically processed with MedCalc version 19.0.5. Results. In psoriatic patients, we found significantly increased levels of HMGB1 (p<0.05), IL-33 (p<0.01), S100A7 (p<0.0001), and S100A12 (p<0.0001). In addition, we found a significant relationship between HMGB1 and S100A7 (Spearman’s rho=0.276, p<0.05) in the patients and significant relationship between HMGB1 and IL-33 in the controls (Spearman’s rho=0.416, p<0.05). We did not find any relationship between observed alarmins and the disease severity. Conclusions. The alarmins HMGB1, IL-33, S100A7, and S100A12 were significantly elevated in the serum of patients, which states the hypothesis that they play specific roles in the immunopathology of psoriasis. However, we have not yet found a relationship between observed alarmins and the disease severity. The discovery of the relationship between HMGB1 and S100A7 is a novelty that should be studied in the future to further clarify its role and importance. |
| format | Article |
| id | doaj-art-4472ece160a54b45a93fc286a8b34df2 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
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| series | Mediators of Inflammation |
| spelling | doaj-art-4472ece160a54b45a93fc286a8b34df22025-02-03T06:05:18ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/84650838465083Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis VulgarisPavel Borsky0Zdenek Fiala1Ctirad Andrys2Martin Beranek3Kvetoslava Hamakova4Andrea Malkova5Tereza Svadlakova6Jan Krejsek7Vladimir Palicka8Lenka Borska9Vit Rehacek10Institute of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove 500 03, Czech RepublicInstitute of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove 500 03, Czech RepublicInstitute of Clinical Immunology and Allergology, University Hospital and Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove 500 03, Czech RepublicInstitute of Clinical Biochemistry and Diagnostics, University Hospital and Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove 500 03, Czech RepublicClinic of Dermal and Venereal Diseases, University Hospital Hradec Kralove, Hradec Kralove 500 03, Czech RepublicInstitute of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove 500 03, Czech RepublicInstitute of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove 500 03, Czech RepublicInstitute of Clinical Immunology and Allergology, University Hospital and Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove 500 03, Czech RepublicInstitute of Clinical Biochemistry and Diagnostics, University Hospital and Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove 500 03, Czech RepublicInstitute of Pathological Physiology, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove 500 03, Czech RepublicTransfusion Center, University Hospital Hradec Kralove, Hradec Kralove 500 03, Czech RepublicBackground. Psoriasis vulgaris is a chronic autoimmune disease associated with systemic inflammation. Increased levels of numerous cytokines, chemokines, growth factors, and other molecules were found in the skin and in the circulation of psoriatic patients. Alarmins, also known as danger signals, are intracellular proteins, which are released to an extracellular space after infection or damage. They are the markers of cell destructive processes. Objective. The aim of the present study was to evaluate the suitability of selected alarmins (HMGB1, IL-33, S100A7, and S100A12) as potential biomarkers of severity of psoriasis and to explore possible relationships between these proteins for the purpose of better understanding their roles in the immunopathology of psoriasis. Methods. The serum levels of selected alarmins were measured in 63 psoriatic patients and 95 control individuals. The levels were assessed by the ELISA technique using commercial kits. The data were statistically processed with MedCalc version 19.0.5. Results. In psoriatic patients, we found significantly increased levels of HMGB1 (p<0.05), IL-33 (p<0.01), S100A7 (p<0.0001), and S100A12 (p<0.0001). In addition, we found a significant relationship between HMGB1 and S100A7 (Spearman’s rho=0.276, p<0.05) in the patients and significant relationship between HMGB1 and IL-33 in the controls (Spearman’s rho=0.416, p<0.05). We did not find any relationship between observed alarmins and the disease severity. Conclusions. The alarmins HMGB1, IL-33, S100A7, and S100A12 were significantly elevated in the serum of patients, which states the hypothesis that they play specific roles in the immunopathology of psoriasis. However, we have not yet found a relationship between observed alarmins and the disease severity. The discovery of the relationship between HMGB1 and S100A7 is a novelty that should be studied in the future to further clarify its role and importance.http://dx.doi.org/10.1155/2020/8465083 |
| spellingShingle | Pavel Borsky Zdenek Fiala Ctirad Andrys Martin Beranek Kvetoslava Hamakova Andrea Malkova Tereza Svadlakova Jan Krejsek Vladimir Palicka Lenka Borska Vit Rehacek Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris Mediators of Inflammation |
| title | Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris |
| title_full | Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris |
| title_fullStr | Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris |
| title_full_unstemmed | Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris |
| title_short | Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris |
| title_sort | alarmins hmgb1 il 33 s100a7 and s100a12 in psoriasis vulgaris |
| url | http://dx.doi.org/10.1155/2020/8465083 |
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