Bioinspired artificial antioxidases for efficient redox homeostasis and maxillofacial bone regeneration
Abstract Reconstructing large, inflammatory maxillofacial defects using stem cell-based therapy faces challenges from adverse microenvironments, including high levels of reactive oxygen species (ROS), inadequate oxygen, and intensive inflammation. Here, inspired by the reaction mechanisms of intrace...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56179-0 |
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| author | Ting Wang Mingru Bai Wei Geng Mohsen Adeli Ling Ye Chong Cheng |
| author_facet | Ting Wang Mingru Bai Wei Geng Mohsen Adeli Ling Ye Chong Cheng |
| author_sort | Ting Wang |
| collection | DOAJ |
| description | Abstract Reconstructing large, inflammatory maxillofacial defects using stem cell-based therapy faces challenges from adverse microenvironments, including high levels of reactive oxygen species (ROS), inadequate oxygen, and intensive inflammation. Here, inspired by the reaction mechanisms of intracellular antioxidant defense systems, we propose the de novo design of an artificial antioxidase using Ru-doped layered double hydroxide (Ru-hydroxide) for efficient redox homeostasis and maxillofacial bone regeneration. Our studies demonstrate that Ru-hydroxide consists hydroxyls-synergistic monoatomic Ru centers, which efficiently react with oxygen species and collaborate with hydroxyls for rapid proton and electron transfer, thus exhibiting efficient, broad-spectrum, and robust ROS scavenging performance. Moreover, Ru-hydroxide can effectively sustain stem cell viability and osteogenic differentiation in elevated ROS environments, modulating the inflammatory microenvironment during bone tissue regeneration in male mice. We believe this Ru-hydroxide development offers a promising avenue for designing antioxidase-like materials to treat various inflammation-associated disorders, including arthritis, diabetic wounds, enteritis, and bone fractures. |
| format | Article |
| id | doaj-art-446182fbeab1488eab8665a0ae83bc49 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-446182fbeab1488eab8665a0ae83bc492025-01-26T12:41:36ZengNature PortfolioNature Communications2041-17232025-01-0116112010.1038/s41467-025-56179-0Bioinspired artificial antioxidases for efficient redox homeostasis and maxillofacial bone regenerationTing Wang0Mingru Bai1Wei Geng2Mohsen Adeli3Ling Ye4Chong Cheng5College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversityState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversityInstitute of Chemistry and Biochemistry, Free University of BerlinState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversityAbstract Reconstructing large, inflammatory maxillofacial defects using stem cell-based therapy faces challenges from adverse microenvironments, including high levels of reactive oxygen species (ROS), inadequate oxygen, and intensive inflammation. Here, inspired by the reaction mechanisms of intracellular antioxidant defense systems, we propose the de novo design of an artificial antioxidase using Ru-doped layered double hydroxide (Ru-hydroxide) for efficient redox homeostasis and maxillofacial bone regeneration. Our studies demonstrate that Ru-hydroxide consists hydroxyls-synergistic monoatomic Ru centers, which efficiently react with oxygen species and collaborate with hydroxyls for rapid proton and electron transfer, thus exhibiting efficient, broad-spectrum, and robust ROS scavenging performance. Moreover, Ru-hydroxide can effectively sustain stem cell viability and osteogenic differentiation in elevated ROS environments, modulating the inflammatory microenvironment during bone tissue regeneration in male mice. We believe this Ru-hydroxide development offers a promising avenue for designing antioxidase-like materials to treat various inflammation-associated disorders, including arthritis, diabetic wounds, enteritis, and bone fractures.https://doi.org/10.1038/s41467-025-56179-0 |
| spellingShingle | Ting Wang Mingru Bai Wei Geng Mohsen Adeli Ling Ye Chong Cheng Bioinspired artificial antioxidases for efficient redox homeostasis and maxillofacial bone regeneration Nature Communications |
| title | Bioinspired artificial antioxidases for efficient redox homeostasis and maxillofacial bone regeneration |
| title_full | Bioinspired artificial antioxidases for efficient redox homeostasis and maxillofacial bone regeneration |
| title_fullStr | Bioinspired artificial antioxidases for efficient redox homeostasis and maxillofacial bone regeneration |
| title_full_unstemmed | Bioinspired artificial antioxidases for efficient redox homeostasis and maxillofacial bone regeneration |
| title_short | Bioinspired artificial antioxidases for efficient redox homeostasis and maxillofacial bone regeneration |
| title_sort | bioinspired artificial antioxidases for efficient redox homeostasis and maxillofacial bone regeneration |
| url | https://doi.org/10.1038/s41467-025-56179-0 |
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