A cross‐sectional study evaluating the frequency of HIV drug resistance mutations among individuals diagnosed with HIV‐1 in tenofovir disoproxil fumarate‐based pre‐exposure prophylaxis rollout programmes in Kenya, Zimbabwe, Eswatini and South Africa

A cross‐sectional study evaluating the frequency of HIV drug resistance mutations among individuals diagnosed with HIV‐1 in tenofovir disoproxil fumarate‐based pre‐exposure prophylaxis rollout programmes in Kenya, Zimbabwe, Eswatini and South Africa

Abstract Introduction The ongoing rollout of oral tenofovir‐based pre‐exposure prophylaxis (PrEP) has the potential to reduce HIV‐1 incidence, but HIV drug resistance (HIVDR) in individuals who acquire HIV‐1 on PrEP could threaten the treatment effectiveness of overlapping antiretrovirals (tenofovir...

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Main Authors: Urvi M. Parikh, Lauren D. Kudrick, Lisa Levy, Everline Bosek, Bhavna H. Chohan, Irene Mukui, Sarah Masyuko, Nonhlanhla Ndlovu, Imelda Mahaka, Owen Mugurungi, Gertrude Ncube, Anita Hettema, Sindy N. Matse, Saiqa Mullick, Carole L. Wallis, Amy L. Heaps, Kerri J. Penrose, Kevin D. McCormick, Lubbe Wiesner, Peter L. Anderson, Jill M. Peterson, Connie Celum, Barbra A. Richardson, Delivette Castor, Shannon Allen, Kristine Torjesen, John W. Mellors, Global Evaluation of Microbicide Sensitivity (GEMS) Project
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Journal of the International AIDS Society
Subjects:
HIV
HIV prevention
pre‐exposure prophylaxis
drug resistance
tenofovir disoproxil fumarate/emtricitabine
sub‐Saharan Africa
Online Access:https://doi.org/10.1002/jia2.70011
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