Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S

Background Cross-presentation of exogenous antigens in HLA-class I molecules by professional antigen presenting cells (APCs) is crucial for CD8+ T cell function. Recent murine studies show that several non-professional APCs, including cancer-associated fibroblasts (CAFs) also possess this capacity....

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Bibliographic Details
Main Authors:	Peter A van Veelen, Jacques Neefjes, Sjoerd H van der Burg, Thorbald van Hall, Marten Visser, Linda de Bruin, Lukas JAC Hawinkels, James CH Hardwick, Saskia J Santegoets, Tom J Harryvan, Léonie Plug, Lisa Griffioen, Arend Mulder, Gerbrand J van der Heden van Noort, Marlieke LM Jongsma, Miranda H Meeuwsen, Emmanuel JHJ Wiertz, Els ME Verdegaal
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2022-03-01
Series:	Journal for ImmunoTherapy of Cancer
Online Access:	https://jitc.bmj.com/content/10/3/e003591.full
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Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S

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