Correlation between salivary ANG-2 level and inflammation activity of oral lichen planus
Objective To assay the salivary ANG-2 level of oral lichen planus (OLP) patients, and analyze its correlation with inflammatory activity of OLP. Methods Eighty-nine OLP patients were included, and divided into four subgroups as non-erosive asymptomatic (NEA), non-erosive symptomatic (NES), minor-ero...
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Editorial Office of Stomatology
2025-01-01
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| Series: | Kouqiang yixue |
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| author | XIANG Yuanyi, LUO Jingjing, LI Haiyang, WU Zhongting, ZHOU Hongmei |
| author_facet | XIANG Yuanyi, LUO Jingjing, LI Haiyang, WU Zhongting, ZHOU Hongmei |
| author_sort | XIANG Yuanyi, LUO Jingjing, LI Haiyang, WU Zhongting, ZHOU Hongmei |
| collection | DOAJ |
| description | Objective To assay the salivary ANG-2 level of oral lichen planus (OLP) patients, and analyze its correlation with inflammatory activity of OLP. Methods Eighty-nine OLP patients were included, and divided into four subgroups as non-erosive asymptomatic (NEA), non-erosive symptomatic (NES), minor-erosive (MIE) and major-erosive (MAE) groups. Fifteen healthy adults were recruited as controls. Whole unstimulated saliva was collected from each participant, and the salivary ANG-2 level was measured by chemiluminescence immunoassays (CLIA) for analysis. Normal oral mucosal tissue, non-erosive and erosive OLP tissues were collected to detect and analyze the expression of ANG-2 positive blood vessels by immunohistochemistry (IHC). Results The baselines of age and gender between OLP and control groups showed no significant difference. Compared to controls, the salivary ANG-2 levels of OLP group, non-erosive and erosive OLP subgroups were significantly higher (P<0.05), in which erosive OLP group was higher than non-erosive OLP group (P=0.022); NES subgroup was slightly higher than NEA (P=0.048), and there was no statistical significance between MIA and MEA subgroups (P=0.067). Spearman correlation analysis showed a positive correlation between salivary ANG-2 level and inflammation activity in OLP patients (r=0.314,P=0.003). The expression of ANG-2 in non-erosive OLP mucosal tissues slightly increased than normal oral mucosal tissue (P>0.05), but there was no significant difference. The expression of ANG-2 in erosive OLP mucosal tissues significantly increased than normal oral mucosal tissue (P<0.001) and non-erosive OLP group (P<0.001). Conclusion There is a certain correlation between salivary ANG-2 level and inflammatory activity of OLP, indicating that salivary ANG-2 level is probable to be one of the inflammatory activity indicators to monitor the state-variation of OLP as a clinical non-invasive method. |
| format | Article |
| id | doaj-art-445d14524f6342eab38f1a1da1ae90e9 |
| institution | Kabale University |
| issn | 1003-9872 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Editorial Office of Stomatology |
| record_format | Article |
| series | Kouqiang yixue |
| spelling | doaj-art-445d14524f6342eab38f1a1da1ae90e92025-01-24T02:09:30ZzhoEditorial Office of StomatologyKouqiang yixue1003-98722025-01-01451455010.13591/j.cnki.kqyx.2025.01.007Correlation between salivary ANG-2 level and inflammation activity of oral lichen planusXIANG Yuanyi, LUO Jingjing, LI Haiyang, WU Zhongting, ZHOU Hongmei0State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Frontier Innovation Center for Dental Medicine Plus, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaObjective To assay the salivary ANG-2 level of oral lichen planus (OLP) patients, and analyze its correlation with inflammatory activity of OLP. Methods Eighty-nine OLP patients were included, and divided into four subgroups as non-erosive asymptomatic (NEA), non-erosive symptomatic (NES), minor-erosive (MIE) and major-erosive (MAE) groups. Fifteen healthy adults were recruited as controls. Whole unstimulated saliva was collected from each participant, and the salivary ANG-2 level was measured by chemiluminescence immunoassays (CLIA) for analysis. Normal oral mucosal tissue, non-erosive and erosive OLP tissues were collected to detect and analyze the expression of ANG-2 positive blood vessels by immunohistochemistry (IHC). Results The baselines of age and gender between OLP and control groups showed no significant difference. Compared to controls, the salivary ANG-2 levels of OLP group, non-erosive and erosive OLP subgroups were significantly higher (P<0.05), in which erosive OLP group was higher than non-erosive OLP group (P=0.022); NES subgroup was slightly higher than NEA (P=0.048), and there was no statistical significance between MIA and MEA subgroups (P=0.067). Spearman correlation analysis showed a positive correlation between salivary ANG-2 level and inflammation activity in OLP patients (r=0.314,P=0.003). The expression of ANG-2 in non-erosive OLP mucosal tissues slightly increased than normal oral mucosal tissue (P>0.05), but there was no significant difference. The expression of ANG-2 in erosive OLP mucosal tissues significantly increased than normal oral mucosal tissue (P<0.001) and non-erosive OLP group (P<0.001). Conclusion There is a certain correlation between salivary ANG-2 level and inflammatory activity of OLP, indicating that salivary ANG-2 level is probable to be one of the inflammatory activity indicators to monitor the state-variation of OLP as a clinical non-invasive method.https://www.stomatology.cn/fileup/1003-9872/PDF/1737011912747-767862958.pdf|oral lichen planus|inflammatory activity|angiopoietin 2|saliva|non-invasive monitoring |
| spellingShingle | XIANG Yuanyi, LUO Jingjing, LI Haiyang, WU Zhongting, ZHOU Hongmei Correlation between salivary ANG-2 level and inflammation activity of oral lichen planus Kouqiang yixue |oral lichen planus|inflammatory activity|angiopoietin 2|saliva|non-invasive monitoring |
| title | Correlation between salivary ANG-2 level and inflammation activity of oral lichen planus |
| title_full | Correlation between salivary ANG-2 level and inflammation activity of oral lichen planus |
| title_fullStr | Correlation between salivary ANG-2 level and inflammation activity of oral lichen planus |
| title_full_unstemmed | Correlation between salivary ANG-2 level and inflammation activity of oral lichen planus |
| title_short | Correlation between salivary ANG-2 level and inflammation activity of oral lichen planus |
| title_sort | correlation between salivary ang 2 level and inflammation activity of oral lichen planus |
| topic | |oral lichen planus|inflammatory activity|angiopoietin 2|saliva|non-invasive monitoring |
| url | https://www.stomatology.cn/fileup/1003-9872/PDF/1737011912747-767862958.pdf |
| work_keys_str_mv | AT xiangyuanyiluojingjinglihaiyangwuzhongtingzhouhongmei correlationbetweensalivaryang2levelandinflammationactivityoforallichenplanus |