From the Search for a Molecular Code of Memory to the Role of Neurotransmitters: A Historical Perspective

The history of the neurochemistry of mnesic processes can be divided into two main periods: the first (1946-1978) was inspired by the results of molecular genetics, providing evidence for storage of hereditary information in the DNA of genes. Therefore, the chemical bases for memory were investigate...

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Main Author: Georges Chapouthier
Format: Article
Language:English
Published: Wiley 2004-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/NP.2004.151
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author Georges Chapouthier
author_facet Georges Chapouthier
author_sort Georges Chapouthier
collection DOAJ
description The history of the neurochemistry of mnesic processes can be divided into two main periods: the first (1946-1978) was inspired by the results of molecular genetics, providing evidence for storage of hereditary information in the DNA of genes. Therefore, the chemical bases for memory were investigated in the macromolecules of the brain. Such attempts were relatively unsuccessful, which led to a second period (starting in 1978) with the research emphasizing, in a less ambitious way, the role of the molecular correlates of mnesic processes, in particular in the main transmitter systems of the brain.
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spelling doaj-art-443eb258c5ba4dc08d58dc8a3b5a93b42025-02-03T01:00:10ZengWileyNeural Plasticity2090-59041687-54432004-01-01113-415115810.1155/NP.2004.151From the Search for a Molecular Code of Memory to the Role of Neurotransmitters: A Historical PerspectiveGeorges Chapouthier0“Vulnérabilité, Adaptation et Psychopathologie”, CNRS UMR 7593, Hôpital Pitié-Salpêtrière, 91 Bd de l'Hôpital, Paris cedex 13 75634, FranceThe history of the neurochemistry of mnesic processes can be divided into two main periods: the first (1946-1978) was inspired by the results of molecular genetics, providing evidence for storage of hereditary information in the DNA of genes. Therefore, the chemical bases for memory were investigated in the macromolecules of the brain. Such attempts were relatively unsuccessful, which led to a second period (starting in 1978) with the research emphasizing, in a less ambitious way, the role of the molecular correlates of mnesic processes, in particular in the main transmitter systems of the brain.http://dx.doi.org/10.1155/NP.2004.151
spellingShingle Georges Chapouthier
From the Search for a Molecular Code of Memory to the Role of Neurotransmitters: A Historical Perspective
Neural Plasticity
title From the Search for a Molecular Code of Memory to the Role of Neurotransmitters: A Historical Perspective
title_full From the Search for a Molecular Code of Memory to the Role of Neurotransmitters: A Historical Perspective
title_fullStr From the Search for a Molecular Code of Memory to the Role of Neurotransmitters: A Historical Perspective
title_full_unstemmed From the Search for a Molecular Code of Memory to the Role of Neurotransmitters: A Historical Perspective
title_short From the Search for a Molecular Code of Memory to the Role of Neurotransmitters: A Historical Perspective
title_sort from the search for a molecular code of memory to the role of neurotransmitters a historical perspective
url http://dx.doi.org/10.1155/NP.2004.151
work_keys_str_mv AT georgeschapouthier fromthesearchforamolecularcodeofmemorytotheroleofneurotransmittersahistoricalperspective