Efficacy and safety of the metformin-mazindol anorectic combination in rat
The current study investigates the anorectic interaction and safety of the mazindol-metformin combination in rats. Isobologram and interaction index were used to determine anorectic interaction between mazindol and metformin in the sweetened milk model. The safety profile of the mazindol-metformin c...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2021-06-01
|
| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acph-2021-0019 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832570297657589760 |
|---|---|
| author | Argüelles-Tello Federico Roa-Coria José Eduardo Zúñiga-Romero Ángel Huerta-Cruz Juan Carlos Quiñonez-Bastidas Geovanna Nalley Flores-Murrieta Francisco Javier Rocha-González Héctor Isaac Reyes-García Juan Gerardo |
| author_facet | Argüelles-Tello Federico Roa-Coria José Eduardo Zúñiga-Romero Ángel Huerta-Cruz Juan Carlos Quiñonez-Bastidas Geovanna Nalley Flores-Murrieta Francisco Javier Rocha-González Héctor Isaac Reyes-García Juan Gerardo |
| author_sort | Argüelles-Tello Federico |
| collection | DOAJ |
| description | The current study investigates the anorectic interaction and safety of the mazindol-metformin combination in rats. Isobologram and interaction index were used to determine anorectic interaction between mazindol and metformin in the sweetened milk model. The safety profile of the mazindol-metformin combination was determined by measuring anxiety, blood pressure, hematic biometry and blood chemistry. An acute dose of mazindol and metformin administered per os, individually or as a mixture, has reduced the milk consumption in rats in a dose-dependent manner. Theoretical effective dose 40 (ED40t) did not differ from the experimental effective dose 40 (ED40e) obtained with the mazindol-metformin mixture in the anorexia experiments, by Student′s t-test. In addition, the interaction index confirmed the additive anorectic effect between both drugs. A single oral dose of ED40e mazindol-metformin mixture induced anxiolysis in the elevated plus-maze test. Moreover, oral administration of mazindol-metformin combination for 3 months significantly decreased glycemia, but not blood pressure nor other parameters of hematic biometry and blood chemistry. Results suggest that mazindol-metformin combination exerts an additive anorectic effect, as well as anxiolytic and hypoglycemic properties. Mazindol-metformin combination might be useful in obese patients with anxiety disorders or diabetes risk factors. |
| format | Article |
| id | doaj-art-442158c5f19e4e5da26053a3280b6b02 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-442158c5f19e4e5da26053a3280b6b022025-02-02T15:49:11ZengSciendoActa Pharmaceutica1846-95582021-06-0171227929110.2478/acph-2021-0019acph-2021-0019Efficacy and safety of the metformin-mazindol anorectic combination in ratArgüelles-Tello Federico0Roa-Coria José Eduardo1Zúñiga-Romero Ángel2Huerta-Cruz Juan Carlos3Quiñonez-Bastidas Geovanna Nalley4Flores-Murrieta Francisco Javier5Rocha-González Héctor Isaac6Reyes-García Juan Gerardo7Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón s/n Col. Casco de Santo Tomas, Miguel Hidalgo, 11340, Ciudad de México, MéxicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón s/n Col. Casco de Santo Tomas, Miguel Hidalgo, 11340, Ciudad de México, MéxicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón s/n Col. Casco de Santo Tomas, Miguel Hidalgo, 11340, Ciudad de México, MéxicoUnidad de Investigación en Farmacología Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas Secretaría de Salud, Calzada de Tlalpan 4502, Col. Belisario Domínguez Sección XVI, Tlalpan, 14080, Ciudad de México MéxicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón s/n Col. Casco de Santo Tomas, Miguel Hidalgo, 11340, Ciudad de México, MéxicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón s/n Col. Casco de Santo Tomas, Miguel Hidalgo, 11340, Ciudad de México, MéxicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón s/n Col. Casco de Santo Tomas, Miguel Hidalgo, 11340, Ciudad de México, MéxicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón s/n Col. Casco de Santo Tomas, Miguel Hidalgo, 11340, Ciudad de México, MéxicoThe current study investigates the anorectic interaction and safety of the mazindol-metformin combination in rats. Isobologram and interaction index were used to determine anorectic interaction between mazindol and metformin in the sweetened milk model. The safety profile of the mazindol-metformin combination was determined by measuring anxiety, blood pressure, hematic biometry and blood chemistry. An acute dose of mazindol and metformin administered per os, individually or as a mixture, has reduced the milk consumption in rats in a dose-dependent manner. Theoretical effective dose 40 (ED40t) did not differ from the experimental effective dose 40 (ED40e) obtained with the mazindol-metformin mixture in the anorexia experiments, by Student′s t-test. In addition, the interaction index confirmed the additive anorectic effect between both drugs. A single oral dose of ED40e mazindol-metformin mixture induced anxiolysis in the elevated plus-maze test. Moreover, oral administration of mazindol-metformin combination for 3 months significantly decreased glycemia, but not blood pressure nor other parameters of hematic biometry and blood chemistry. Results suggest that mazindol-metformin combination exerts an additive anorectic effect, as well as anxiolytic and hypoglycemic properties. Mazindol-metformin combination might be useful in obese patients with anxiety disorders or diabetes risk factors.https://doi.org/10.2478/acph-2021-0019mazindol-metformin combinationanorectic interactionanxiolysishypoglycemic effect |
| spellingShingle | Argüelles-Tello Federico Roa-Coria José Eduardo Zúñiga-Romero Ángel Huerta-Cruz Juan Carlos Quiñonez-Bastidas Geovanna Nalley Flores-Murrieta Francisco Javier Rocha-González Héctor Isaac Reyes-García Juan Gerardo Efficacy and safety of the metformin-mazindol anorectic combination in rat Acta Pharmaceutica mazindol-metformin combination anorectic interaction anxiolysis hypoglycemic effect |
| title | Efficacy and safety of the metformin-mazindol anorectic combination in rat |
| title_full | Efficacy and safety of the metformin-mazindol anorectic combination in rat |
| title_fullStr | Efficacy and safety of the metformin-mazindol anorectic combination in rat |
| title_full_unstemmed | Efficacy and safety of the metformin-mazindol anorectic combination in rat |
| title_short | Efficacy and safety of the metformin-mazindol anorectic combination in rat |
| title_sort | efficacy and safety of the metformin mazindol anorectic combination in rat |
| topic | mazindol-metformin combination anorectic interaction anxiolysis hypoglycemic effect |
| url | https://doi.org/10.2478/acph-2021-0019 |
| work_keys_str_mv | AT arguellestellofederico efficacyandsafetyofthemetforminmazindolanorecticcombinationinrat AT roacoriajoseeduardo efficacyandsafetyofthemetforminmazindolanorecticcombinationinrat AT zunigaromeroangel efficacyandsafetyofthemetforminmazindolanorecticcombinationinrat AT huertacruzjuancarlos efficacyandsafetyofthemetforminmazindolanorecticcombinationinrat AT quinonezbastidasgeovannanalley efficacyandsafetyofthemetforminmazindolanorecticcombinationinrat AT floresmurrietafranciscojavier efficacyandsafetyofthemetforminmazindolanorecticcombinationinrat AT rochagonzalezhectorisaac efficacyandsafetyofthemetforminmazindolanorecticcombinationinrat AT reyesgarciajuangerardo efficacyandsafetyofthemetforminmazindolanorecticcombinationinrat |