From bench to bedside: elucidating VEGF(R) inhibitor-related heart failure in cancer treatment

From bench to bedside: elucidating VEGF(R) inhibitor-related heart failure in cancer treatment

Abstract Background Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors play a pivotal role in treating various tumors; however, the clinical characteristics and molecular mechanisms of their associated heart failure (HF) remain incompletely understood. Methods We investig...

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Bibliographic Details
Main Authors: Shengkun Peng, MinHong Cai, Hongyu Kuang, Anqi Lin, Qinghua Ma, Xiaoqin Dai, Peng Luo, Yijun Liu, Guo Zhang, Yifeng Bai
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Translational Medicine
Subjects:
Vascular endothelial growth factor
Vascular endothelial growth factor receptor
VigiBase
VEGF(R) inhibitor-related heart failure
Mouse model
Online Access:https://doi.org/10.1186/s12967-025-06133-x
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