The influence of HIV infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults: a systematic review and meta-analysis of observation studies
IntroductionHuman immunodeficiency virus (HIV) infection is linked to myocardial fibrosis. Observational studies using cardiac magnetic resonance (CMR) have explored this relationship but scarcity of data synthesis limits our understanding. Our systematic review and meta-analysis aimed to synthesize...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1534533/full |
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| author | Katongo Hope Mutengo Katongo Hope Mutengo Bruno Bezerra Lima Wilbroad Mutale Aggrey Mweemba Lorrita Kabwe Clive Banda Callistus Kaayunga Mutale Mulenga Douglas Heimburger Sepiso K. Masenga John Jeffrey Carr Annet Kirabo |
| author_facet | Katongo Hope Mutengo Katongo Hope Mutengo Bruno Bezerra Lima Wilbroad Mutale Aggrey Mweemba Lorrita Kabwe Clive Banda Callistus Kaayunga Mutale Mulenga Douglas Heimburger Sepiso K. Masenga John Jeffrey Carr Annet Kirabo |
| author_sort | Katongo Hope Mutengo |
| collection | DOAJ |
| description | IntroductionHuman immunodeficiency virus (HIV) infection is linked to myocardial fibrosis. Observational studies using cardiac magnetic resonance (CMR) have explored this relationship but scarcity of data synthesis limits our understanding. Our systematic review and meta-analysis aimed to synthesize associations between HIV and myocardial fibrosis from CMR-based observational studies in adults.MethodsWe identified 12 studies (2013–2024) with 1,769 participants [1,117 people with HIV (PWH)]. Three studies were cohort and nine were cross-sectional. Meta-analysis included seven studies on late gadolinium enhancement (LGE) (1,081 participants: 669 PWH), eight on native T1 mapping (840 participants: 467 PWH), and ten on ECVF (1,603 participants: 992 PWH). We examined myocardial fibrosis prevalence via the prevalence difference in LGE, and severity by mean differences in native T1 mapping values [milliseconds (ms)] and global extracellular volume fraction (ECVF,%) between PWH and HIV-uninfected individuals, using random effects model.Results and discussionPooled analyses showed PWH had a 33% higher prevalence of LGE (95% CI: 12.0%–54.0%, I2 = 94.5%, p < 0.001), a mean native T1 mapping difference of 27.30 ms (95% CI: 11.21–43.39 ms, I2 = 88.2%, p < 0.001), and a mean ECVF difference of 1.85% (95% CI: 0.63%–3.08%, I2 = 90.5%, p < 0.001), respectively. Meta-regression showed no significant associations between ECVF and demographic, HIV-related, or cardiac factors. LGE and native T1 mapping analyses lacked sufficient data for meta-regression. In conclusion, PWH exhibit significantly higher prevalence and severity of myocardial fibrosis compared to HIV-uninfected individuals. But standardized methodologies and further research are essential to enhance consistency.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=533379, CRD [42024533379]. |
| format | Article |
| id | doaj-art-4411acba74ce4627ae1661689cb570ca |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-4411acba74ce4627ae1661689cb570ca2025-01-29T06:46:19ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011210.3389/fcvm.2025.15345331534533The influence of HIV infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults: a systematic review and meta-analysis of observation studiesKatongo Hope Mutengo0Katongo Hope Mutengo1Bruno Bezerra Lima2Wilbroad Mutale3Aggrey Mweemba4Lorrita Kabwe5Clive Banda6Callistus Kaayunga7Mutale Mulenga8Douglas Heimburger9Sepiso K. Masenga10John Jeffrey Carr11Annet Kirabo12Department of Internal Medicine, Ministry of Health, Monze Mission Hospital, Monze, ZambiaMulungushi University School of Medicine and Health Sciences, HAND Research Group, Livingstone, ZambiaDivision of Cardiology, Vanderbilt University Medical Center, Nashville, TN, United StatesSchool of Public Health, University of Zambia, Lusaka, ZambiaMinistry of Health, Nephrology Unit, University Teaching Hospital Lusaka Adult Hospital, Lusaka, ZambiaDepartment of Adult Cardiology, Ministry of Health, National Heart Hospital, Lusaka, ZambiaMinistry of Health, Southern Province Health Office, Choma, ZambiaMinistry of Health, Southern Province Health Office, Choma, ZambiaDepartment of Internal Medicine, Ministry of Health, Monze Mission Hospital, Monze, ZambiaVanderbilt University Medical Center, Vanderbilt Institute for Global Health, Nashville, TN, United StatesMulungushi University School of Medicine and Health Sciences, HAND Research Group, Livingstone, ZambiaDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States0Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, United StatesIntroductionHuman immunodeficiency virus (HIV) infection is linked to myocardial fibrosis. Observational studies using cardiac magnetic resonance (CMR) have explored this relationship but scarcity of data synthesis limits our understanding. Our systematic review and meta-analysis aimed to synthesize associations between HIV and myocardial fibrosis from CMR-based observational studies in adults.MethodsWe identified 12 studies (2013–2024) with 1,769 participants [1,117 people with HIV (PWH)]. Three studies were cohort and nine were cross-sectional. Meta-analysis included seven studies on late gadolinium enhancement (LGE) (1,081 participants: 669 PWH), eight on native T1 mapping (840 participants: 467 PWH), and ten on ECVF (1,603 participants: 992 PWH). We examined myocardial fibrosis prevalence via the prevalence difference in LGE, and severity by mean differences in native T1 mapping values [milliseconds (ms)] and global extracellular volume fraction (ECVF,%) between PWH and HIV-uninfected individuals, using random effects model.Results and discussionPooled analyses showed PWH had a 33% higher prevalence of LGE (95% CI: 12.0%–54.0%, I2 = 94.5%, p < 0.001), a mean native T1 mapping difference of 27.30 ms (95% CI: 11.21–43.39 ms, I2 = 88.2%, p < 0.001), and a mean ECVF difference of 1.85% (95% CI: 0.63%–3.08%, I2 = 90.5%, p < 0.001), respectively. Meta-regression showed no significant associations between ECVF and demographic, HIV-related, or cardiac factors. LGE and native T1 mapping analyses lacked sufficient data for meta-regression. In conclusion, PWH exhibit significantly higher prevalence and severity of myocardial fibrosis compared to HIV-uninfected individuals. But standardized methodologies and further research are essential to enhance consistency.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=533379, CRD [42024533379].https://www.frontiersin.org/articles/10.3389/fcvm.2025.1534533/fullmyocardialfibrosisHIVCMRLGEECVF |
| spellingShingle | Katongo Hope Mutengo Katongo Hope Mutengo Bruno Bezerra Lima Wilbroad Mutale Aggrey Mweemba Lorrita Kabwe Clive Banda Callistus Kaayunga Mutale Mulenga Douglas Heimburger Sepiso K. Masenga John Jeffrey Carr Annet Kirabo The influence of HIV infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults: a systematic review and meta-analysis of observation studies Frontiers in Cardiovascular Medicine myocardial fibrosis HIV CMR LGE ECVF |
| title | The influence of HIV infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults: a systematic review and meta-analysis of observation studies |
| title_full | The influence of HIV infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults: a systematic review and meta-analysis of observation studies |
| title_fullStr | The influence of HIV infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults: a systematic review and meta-analysis of observation studies |
| title_full_unstemmed | The influence of HIV infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults: a systematic review and meta-analysis of observation studies |
| title_short | The influence of HIV infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults: a systematic review and meta-analysis of observation studies |
| title_sort | influence of hiv infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults a systematic review and meta analysis of observation studies |
| topic | myocardial fibrosis HIV CMR LGE ECVF |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1534533/full |
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