Optimal Analysis Method for Dynamic Contrast-Enhanced Diffuse Optical Tomography
Diffuse Optical Tomography (DOT) is an optical imaging modality that has various clinical applications. However, the spatial resolution and quantitative accuracy of DOT is poor due to strong photon scatting in biological tissue. Structural a priori information from another high spatial resolution im...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2011/426503 |
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| _version_ | 1832559411587973120 |
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| author | Michael Ghijsen Yuting Lin Mitchell Hsing Orhan Nalcioglu Gultekin Gulsen |
| author_facet | Michael Ghijsen Yuting Lin Mitchell Hsing Orhan Nalcioglu Gultekin Gulsen |
| author_sort | Michael Ghijsen |
| collection | DOAJ |
| description | Diffuse Optical Tomography (DOT) is an optical imaging modality that has various clinical applications. However, the spatial resolution and quantitative accuracy of DOT is poor due to strong photon scatting in biological tissue. Structural a priori information from another high spatial resolution imaging modality such as Magnetic Resonance Imaging (MRI) has been demonstrated to significantly improve DOT accuracy. In addition, a contrast agent can be used to obtain differential absorption images of the lesion by using dynamic contrast enhanced DOT (DCE-DOT). This produces a relative absorption map that consists of subtracting a reconstructed baseline image from reconstructed images in which optical contrast is included. In this study, we investigated and compared different reconstruction methods and analysis approaches for regular endogenous DOT and DCE-DOT with and without MR anatomical a priori information for arbitrarily-shaped objects. Our phantom and animal studies have shown that superior image quality and higher accuracy can be achieved using DCE-DOT together with MR structural a priori information. Hence, implementation of a combined MRI-DOT system to image ICG enhancement can potentially be a promising tool for breast cancer imaging. |
| format | Article |
| id | doaj-art-440a6553395541a5bb1047d824fe249f |
| institution | Kabale University |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-440a6553395541a5bb1047d824fe249f2025-02-03T01:30:09ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962011-01-01201110.1155/2011/426503426503Optimal Analysis Method for Dynamic Contrast-Enhanced Diffuse Optical TomographyMichael Ghijsen0Yuting Lin1Mitchell Hsing2Orhan Nalcioglu3Gultekin Gulsen4Department of Radiological Sciences, John Tu and Thomas Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA 92697, USADepartment of Radiological Sciences, John Tu and Thomas Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA 92697, USADepartment of Radiological Sciences, John Tu and Thomas Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA 92697, USADepartment of Radiological Sciences, John Tu and Thomas Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA 92697, USADepartment of Radiological Sciences, John Tu and Thomas Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA 92697, USADiffuse Optical Tomography (DOT) is an optical imaging modality that has various clinical applications. However, the spatial resolution and quantitative accuracy of DOT is poor due to strong photon scatting in biological tissue. Structural a priori information from another high spatial resolution imaging modality such as Magnetic Resonance Imaging (MRI) has been demonstrated to significantly improve DOT accuracy. In addition, a contrast agent can be used to obtain differential absorption images of the lesion by using dynamic contrast enhanced DOT (DCE-DOT). This produces a relative absorption map that consists of subtracting a reconstructed baseline image from reconstructed images in which optical contrast is included. In this study, we investigated and compared different reconstruction methods and analysis approaches for regular endogenous DOT and DCE-DOT with and without MR anatomical a priori information for arbitrarily-shaped objects. Our phantom and animal studies have shown that superior image quality and higher accuracy can be achieved using DCE-DOT together with MR structural a priori information. Hence, implementation of a combined MRI-DOT system to image ICG enhancement can potentially be a promising tool for breast cancer imaging.http://dx.doi.org/10.1155/2011/426503 |
| spellingShingle | Michael Ghijsen Yuting Lin Mitchell Hsing Orhan Nalcioglu Gultekin Gulsen Optimal Analysis Method for Dynamic Contrast-Enhanced Diffuse Optical Tomography International Journal of Biomedical Imaging |
| title | Optimal Analysis Method for Dynamic Contrast-Enhanced Diffuse Optical Tomography |
| title_full | Optimal Analysis Method for Dynamic Contrast-Enhanced Diffuse Optical Tomography |
| title_fullStr | Optimal Analysis Method for Dynamic Contrast-Enhanced Diffuse Optical Tomography |
| title_full_unstemmed | Optimal Analysis Method for Dynamic Contrast-Enhanced Diffuse Optical Tomography |
| title_short | Optimal Analysis Method for Dynamic Contrast-Enhanced Diffuse Optical Tomography |
| title_sort | optimal analysis method for dynamic contrast enhanced diffuse optical tomography |
| url | http://dx.doi.org/10.1155/2011/426503 |
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