Weighted Wilcoxon-Type Rank Test for Interval Censored Data

Interval censored (IC) failure time data are often observed in medical follow-up studies and clinical trials where subjects can only be followed periodically, and the failure time can only be known to lie in an interval. In this paper, we propose a weighted Wilcoxon-type rank test for the problem of...

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Main Authors: Ching-fu Shen, Jin-long Huang, Chin-san Lee
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Journal of Applied Mathematics
Online Access:http://dx.doi.org/10.1155/2013/273954
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author Ching-fu Shen
Jin-long Huang
Chin-san Lee
author_facet Ching-fu Shen
Jin-long Huang
Chin-san Lee
author_sort Ching-fu Shen
collection DOAJ
description Interval censored (IC) failure time data are often observed in medical follow-up studies and clinical trials where subjects can only be followed periodically, and the failure time can only be known to lie in an interval. In this paper, we propose a weighted Wilcoxon-type rank test for the problem of comparing two IC samples. Under a very general sampling technique developed by Fay (1999), the mean and variance of the test statistics under the null hypothesis can be derived. Through simulation studies, we find that the performance of the proposed test is better than that of the two existing Wilcoxon-type rank tests proposed by Mantel (1967) and R. Peto and J. Peto (1972). The proposed test is illustrated by means of an example involving patients in AIDS cohort studies.
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publishDate 2013-01-01
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series Journal of Applied Mathematics
spelling doaj-art-44034359664a489aaf83baac85a800682025-02-03T01:33:12ZengWileyJournal of Applied Mathematics1110-757X1687-00422013-01-01201310.1155/2013/273954273954Weighted Wilcoxon-Type Rank Test for Interval Censored DataChing-fu Shen0Jin-long Huang1Chin-san Lee2Department of Applied Mathematics, National Sun Yat-sen University, Kaohsiung 80424, TaiwanCenter for Fundamental Sciences, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDepartment of Applied Mathematics, National Sun Yat-sen University, Kaohsiung 80424, TaiwanInterval censored (IC) failure time data are often observed in medical follow-up studies and clinical trials where subjects can only be followed periodically, and the failure time can only be known to lie in an interval. In this paper, we propose a weighted Wilcoxon-type rank test for the problem of comparing two IC samples. Under a very general sampling technique developed by Fay (1999), the mean and variance of the test statistics under the null hypothesis can be derived. Through simulation studies, we find that the performance of the proposed test is better than that of the two existing Wilcoxon-type rank tests proposed by Mantel (1967) and R. Peto and J. Peto (1972). The proposed test is illustrated by means of an example involving patients in AIDS cohort studies.http://dx.doi.org/10.1155/2013/273954
spellingShingle Ching-fu Shen
Jin-long Huang
Chin-san Lee
Weighted Wilcoxon-Type Rank Test for Interval Censored Data
Journal of Applied Mathematics
title Weighted Wilcoxon-Type Rank Test for Interval Censored Data
title_full Weighted Wilcoxon-Type Rank Test for Interval Censored Data
title_fullStr Weighted Wilcoxon-Type Rank Test for Interval Censored Data
title_full_unstemmed Weighted Wilcoxon-Type Rank Test for Interval Censored Data
title_short Weighted Wilcoxon-Type Rank Test for Interval Censored Data
title_sort weighted wilcoxon type rank test for interval censored data
url http://dx.doi.org/10.1155/2013/273954
work_keys_str_mv AT chingfushen weightedwilcoxontyperanktestforintervalcensoreddata
AT jinlonghuang weightedwilcoxontyperanktestforintervalcensoreddata
AT chinsanlee weightedwilcoxontyperanktestforintervalcensoreddata