Icariin Promotes Survival, Proliferation, and Differentiation of Neural Stem Cells In Vitro and in a Rat Model of Alzheimer’s Disease
Alzheimer’s disease (AD) involves the degeneration of cholinergic neurons in the basal forebrain. Neural stem cell (NSC) transplantation has emerged as a promising therapeutic approach for treating AD. Icariin (ICA) is the main active component in Epimedium, a traditional Chinese herb. The purpose o...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/9974625 |
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| author | Denglei Ma Lihong Zhao Li Zhang Yali Li Lan Zhang Lin Li |
| author_facet | Denglei Ma Lihong Zhao Li Zhang Yali Li Lan Zhang Lin Li |
| author_sort | Denglei Ma |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) involves the degeneration of cholinergic neurons in the basal forebrain. Neural stem cell (NSC) transplantation has emerged as a promising therapeutic approach for treating AD. Icariin (ICA) is the main active component in Epimedium, a traditional Chinese herb. The purpose of the present study was to investigate the effects and mechanisms of ICA on the proliferation and differentiation of NSCs in the basal forebrain of a fimbria-fornix transection (FFT) rat model. In the present study, ICA promoted the survival, proliferation, and migration of NSCs in vitro. In FFT rats, ICA promoted the proliferation and differentiation of NSCs into neurons and increased the number of cholinergic neurons in the MS and VDB of the basal forebrain. These results suggest that combination therapy of ICA oral administration and NSC transplantation may provide a new potential and effective approach for AD therapy. |
| format | Article |
| id | doaj-art-43e97eb98a6a417da506b681b841067f |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-43e97eb98a6a417da506b681b841067f2025-02-03T01:05:32ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/99746259974625Icariin Promotes Survival, Proliferation, and Differentiation of Neural Stem Cells In Vitro and in a Rat Model of Alzheimer’s DiseaseDenglei Ma0Lihong Zhao1Li Zhang2Yali Li3Lan Zhang4Lin Li5Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing 100053, ChinaDepartment of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing 100053, ChinaDepartment of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing 100053, ChinaDepartment of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing 100053, ChinaDepartment of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing 100053, ChinaDepartment of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing 100053, ChinaAlzheimer’s disease (AD) involves the degeneration of cholinergic neurons in the basal forebrain. Neural stem cell (NSC) transplantation has emerged as a promising therapeutic approach for treating AD. Icariin (ICA) is the main active component in Epimedium, a traditional Chinese herb. The purpose of the present study was to investigate the effects and mechanisms of ICA on the proliferation and differentiation of NSCs in the basal forebrain of a fimbria-fornix transection (FFT) rat model. In the present study, ICA promoted the survival, proliferation, and migration of NSCs in vitro. In FFT rats, ICA promoted the proliferation and differentiation of NSCs into neurons and increased the number of cholinergic neurons in the MS and VDB of the basal forebrain. These results suggest that combination therapy of ICA oral administration and NSC transplantation may provide a new potential and effective approach for AD therapy.http://dx.doi.org/10.1155/2021/9974625 |
| spellingShingle | Denglei Ma Lihong Zhao Li Zhang Yali Li Lan Zhang Lin Li Icariin Promotes Survival, Proliferation, and Differentiation of Neural Stem Cells In Vitro and in a Rat Model of Alzheimer’s Disease Stem Cells International |
| title | Icariin Promotes Survival, Proliferation, and Differentiation of Neural Stem Cells In Vitro and in a Rat Model of Alzheimer’s Disease |
| title_full | Icariin Promotes Survival, Proliferation, and Differentiation of Neural Stem Cells In Vitro and in a Rat Model of Alzheimer’s Disease |
| title_fullStr | Icariin Promotes Survival, Proliferation, and Differentiation of Neural Stem Cells In Vitro and in a Rat Model of Alzheimer’s Disease |
| title_full_unstemmed | Icariin Promotes Survival, Proliferation, and Differentiation of Neural Stem Cells In Vitro and in a Rat Model of Alzheimer’s Disease |
| title_short | Icariin Promotes Survival, Proliferation, and Differentiation of Neural Stem Cells In Vitro and in a Rat Model of Alzheimer’s Disease |
| title_sort | icariin promotes survival proliferation and differentiation of neural stem cells in vitro and in a rat model of alzheimer s disease |
| url | http://dx.doi.org/10.1155/2021/9974625 |
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