Investigating DNA Methylation of Solute Carrier Genes in Colorectal Cancer: A Comprehensive Analysis Using Microarray and Bioinformatics Tools
Colorectal cancer (CRC) is a major global health concern, with a significant impact on morbidity and mortality. The molecular mechanisms underlying CRC, especially DNA methylation patterns in solute carrier (SLC) genes, have gained attention due to their potential role in CRC initiation and progres...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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HH Publisher
2023-12-01
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| Series: | Progress in Microbes and Molecular Biology |
| Online Access: | https://journals.hh-publisher.com/index.php/pmmb/article/view/920 |
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| _version_ | 1832541399119036416 |
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| author | Nur Alia Natasya Zabidi Rashidah Baharudin Nurul Qistina Rus Bakarurraini Nur Alyaa Afifah Md Shahri Francis Tieng Yew Fu Imilia Ismail Muhammad Redha Abdullah Zawawi Jodi Woan-Fei Law Learn-Han Lee Nurul-Syakima Ab Mutalib |
| author_facet | Nur Alia Natasya Zabidi Rashidah Baharudin Nurul Qistina Rus Bakarurraini Nur Alyaa Afifah Md Shahri Francis Tieng Yew Fu Imilia Ismail Muhammad Redha Abdullah Zawawi Jodi Woan-Fei Law Learn-Han Lee Nurul-Syakima Ab Mutalib |
| author_sort | Nur Alia Natasya Zabidi |
| collection | DOAJ |
| description |
Colorectal cancer (CRC) is a major global health concern, with a significant impact on morbidity and mortality. The molecular mechanisms underlying CRC, especially DNA methylation patterns in solute carrier (SLC) genes, have gained attention due to their potential role in CRC initiation and progression. SLC genes encode transporters that play vital roles in maintaining cellular homeostasis, and alterations in their DNA methylation can influence nutrient and metabolite transport, impacting cancer cell behavior. This proposal aims to investigate the DNA methylation status of SLC genes in CRC, utilizing microarray technology and a suite of bioinformatics tools. Methods: Microarray methylation data from CRC and adjacent normal tissues underwent preprocessing, differential methylation analysis, functional enrichment exploration, and correlation analysis for a detailed study of methylation patterns. Results: This study decoded the epigenetic landscape of SLC genes in CRC, promising innovative therapeutic strategies and improved patient outcomes to combat this prevalent malignancy.
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| format | Article |
| id | doaj-art-43e50220da1b42f1b8689732301706be |
| institution | Kabale University |
| issn | 2637-1049 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | HH Publisher |
| record_format | Article |
| series | Progress in Microbes and Molecular Biology |
| spelling | doaj-art-43e50220da1b42f1b8689732301706be2025-02-04T08:39:43ZengHH PublisherProgress in Microbes and Molecular Biology2637-10492023-12-016110.36877/pmmb.a0000393Investigating DNA Methylation of Solute Carrier Genes in Colorectal Cancer: A Comprehensive Analysis Using Microarray and Bioinformatics ToolsNur Alia Natasya ZabidiRashidah BaharudinNurul Qistina Rus BakarurrainiNur Alyaa Afifah Md ShahriFrancis Tieng Yew FuImilia IsmailMuhammad Redha Abdullah ZawawiJodi Woan-Fei LawLearn-Han LeeNurul-Syakima Ab Mutalib Colorectal cancer (CRC) is a major global health concern, with a significant impact on morbidity and mortality. The molecular mechanisms underlying CRC, especially DNA methylation patterns in solute carrier (SLC) genes, have gained attention due to their potential role in CRC initiation and progression. SLC genes encode transporters that play vital roles in maintaining cellular homeostasis, and alterations in their DNA methylation can influence nutrient and metabolite transport, impacting cancer cell behavior. This proposal aims to investigate the DNA methylation status of SLC genes in CRC, utilizing microarray technology and a suite of bioinformatics tools. Methods: Microarray methylation data from CRC and adjacent normal tissues underwent preprocessing, differential methylation analysis, functional enrichment exploration, and correlation analysis for a detailed study of methylation patterns. Results: This study decoded the epigenetic landscape of SLC genes in CRC, promising innovative therapeutic strategies and improved patient outcomes to combat this prevalent malignancy. https://journals.hh-publisher.com/index.php/pmmb/article/view/920 |
| spellingShingle | Nur Alia Natasya Zabidi Rashidah Baharudin Nurul Qistina Rus Bakarurraini Nur Alyaa Afifah Md Shahri Francis Tieng Yew Fu Imilia Ismail Muhammad Redha Abdullah Zawawi Jodi Woan-Fei Law Learn-Han Lee Nurul-Syakima Ab Mutalib Investigating DNA Methylation of Solute Carrier Genes in Colorectal Cancer: A Comprehensive Analysis Using Microarray and Bioinformatics Tools Progress in Microbes and Molecular Biology |
| title | Investigating DNA Methylation of Solute Carrier Genes in Colorectal Cancer: A Comprehensive Analysis Using Microarray and Bioinformatics Tools |
| title_full | Investigating DNA Methylation of Solute Carrier Genes in Colorectal Cancer: A Comprehensive Analysis Using Microarray and Bioinformatics Tools |
| title_fullStr | Investigating DNA Methylation of Solute Carrier Genes in Colorectal Cancer: A Comprehensive Analysis Using Microarray and Bioinformatics Tools |
| title_full_unstemmed | Investigating DNA Methylation of Solute Carrier Genes in Colorectal Cancer: A Comprehensive Analysis Using Microarray and Bioinformatics Tools |
| title_short | Investigating DNA Methylation of Solute Carrier Genes in Colorectal Cancer: A Comprehensive Analysis Using Microarray and Bioinformatics Tools |
| title_sort | investigating dna methylation of solute carrier genes in colorectal cancer a comprehensive analysis using microarray and bioinformatics tools |
| url | https://journals.hh-publisher.com/index.php/pmmb/article/view/920 |
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