Urinary Tract Infections in the First 6 Months after Renal Transplantation
Purpose. Urinary tract infections (UTIs) are common in the first 6 months after renal transplantation, and there are only limited data about UTIs after transplantation in Saudi Arabia in general. Methods. A retrospective study from January 2017 to May 2020 with 6-month follow-up. Results. 279 renal...
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| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2021/3033276 |
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| author | Ziad Arabi Khalefa Al Thiab Abdulrahman Altheaby Ghaleb Aboalsamh Samy Kashkoush Mohamad Almarastani Mohammed F. Shaheen Abdulrahman Altamimi Wael O’hali Khalid Bin Saad Lina Alnajjar Rawan Alhussein Raghad Almuhiteb Bashayr Alqahtani Rayana Alotaibi Marah Alqahtani Mohammed Tawhari |
| author_facet | Ziad Arabi Khalefa Al Thiab Abdulrahman Altheaby Ghaleb Aboalsamh Samy Kashkoush Mohamad Almarastani Mohammed F. Shaheen Abdulrahman Altamimi Wael O’hali Khalid Bin Saad Lina Alnajjar Rawan Alhussein Raghad Almuhiteb Bashayr Alqahtani Rayana Alotaibi Marah Alqahtani Mohammed Tawhari |
| author_sort | Ziad Arabi |
| collection | DOAJ |
| description | Purpose. Urinary tract infections (UTIs) are common in the first 6 months after renal transplantation, and there are only limited data about UTIs after transplantation in Saudi Arabia in general. Methods. A retrospective study from January 2017 to May 2020 with 6-month follow-up. Results. 279 renal transplant recipients were included. Mean age was 43.4 ± 16.0 years, and114 (40.9%) were women. Urinary stents were inserted routinely during transplantation and were removed 35.3 ± 28 days postoperatively. Ninety-seven patients (35%) developed urinary tract infections (UTIs) in the first six months after renal transplantation. Of those who developed the first episode of UTI, the recurrence rates were 57%, 27%, and 14% for having one, two, or three recurrences, respectively. Late urinary stent removals, defined as more than 21 days postoperatively, tended to have more UTIs (OR: 1.43, P: 0.259, CI: 0.76–2.66). Age >40, female gender, history of neurogenic bladder, and transplantation abroad were statistically significant factors associated with UTIs and recurrence. Diabetes, level of immunosuppression, deceased donor renal transplantation, pretransplant residual urine volume, or history of vesicoureteral reflux (VUR) was not associated with a higher incidence of UTIs. UTIs were asymptomatic in 60% but complicated with bacteremia in 6% of the cases. Multidrug resistant organisms (MDROs) were the causative organisms in 42% of cases, and in-hospital treatment was required in about 50% of cases. Norfloxacin + Bactrim DD (160/800 mg) every other day was not associated with the lower risk of developing UTIs compared to the standard prophylaxis daily Bactrim SS (80/400 mg). Conclusion. UTIs and recurrence are common in the first 6 months after renal transplantation. Age >40, female gender, neurogenic bladder, and transplantation abroad are associated with the increased risk of UTIs and recurrence. MDROs are common causative organisms, and hospitalization is frequently required. Dual prophylactic antibiotics did not seem to be advantageous over the standard daily Bactrim. |
| format | Article |
| id | doaj-art-43db2dc89cc14a19a8ada2898f875379 |
| institution | Kabale University |
| issn | 2090-2158 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-43db2dc89cc14a19a8ada2898f8753792025-02-03T05:57:20ZengWileyInternational Journal of Nephrology2090-21582021-01-01202110.1155/2021/3033276Urinary Tract Infections in the First 6 Months after Renal TransplantationZiad Arabi0Khalefa Al Thiab1Abdulrahman Altheaby2Ghaleb Aboalsamh3Samy Kashkoush4Mohamad Almarastani5Mohammed F. Shaheen6Abdulrahman Altamimi7Wael O’hali8Khalid Bin Saad9Lina Alnajjar10Rawan Alhussein11Raghad Almuhiteb12Bashayr Alqahtani13Rayana Alotaibi14Marah Alqahtani15Mohammed Tawhari16Division of Adult Transplant NephrologyKing Abdullah International Medical Research CenterDivision of Adult Transplant NephrologyKing Abdullah International Medical Research CenterKing Abdullah International Medical Research CenterKing Abdullah International Medical Research CenterKing Abdullah International Medical Research CenterKing Abdullah International Medical Research CenterKing Abdullah International Medical Research CenterKing Abdullah International Medical Research CenterDepartment of Pharmacy PracticeCollege of PharmacyCollege of PharmacyCollege of PharmacyCollege of PharmacyCollege of PharmacyDivision of Adult Transplant NephrologyPurpose. Urinary tract infections (UTIs) are common in the first 6 months after renal transplantation, and there are only limited data about UTIs after transplantation in Saudi Arabia in general. Methods. A retrospective study from January 2017 to May 2020 with 6-month follow-up. Results. 279 renal transplant recipients were included. Mean age was 43.4 ± 16.0 years, and114 (40.9%) were women. Urinary stents were inserted routinely during transplantation and were removed 35.3 ± 28 days postoperatively. Ninety-seven patients (35%) developed urinary tract infections (UTIs) in the first six months after renal transplantation. Of those who developed the first episode of UTI, the recurrence rates were 57%, 27%, and 14% for having one, two, or three recurrences, respectively. Late urinary stent removals, defined as more than 21 days postoperatively, tended to have more UTIs (OR: 1.43, P: 0.259, CI: 0.76–2.66). Age >40, female gender, history of neurogenic bladder, and transplantation abroad were statistically significant factors associated with UTIs and recurrence. Diabetes, level of immunosuppression, deceased donor renal transplantation, pretransplant residual urine volume, or history of vesicoureteral reflux (VUR) was not associated with a higher incidence of UTIs. UTIs were asymptomatic in 60% but complicated with bacteremia in 6% of the cases. Multidrug resistant organisms (MDROs) were the causative organisms in 42% of cases, and in-hospital treatment was required in about 50% of cases. Norfloxacin + Bactrim DD (160/800 mg) every other day was not associated with the lower risk of developing UTIs compared to the standard prophylaxis daily Bactrim SS (80/400 mg). Conclusion. UTIs and recurrence are common in the first 6 months after renal transplantation. Age >40, female gender, neurogenic bladder, and transplantation abroad are associated with the increased risk of UTIs and recurrence. MDROs are common causative organisms, and hospitalization is frequently required. Dual prophylactic antibiotics did not seem to be advantageous over the standard daily Bactrim.http://dx.doi.org/10.1155/2021/3033276 |
| spellingShingle | Ziad Arabi Khalefa Al Thiab Abdulrahman Altheaby Ghaleb Aboalsamh Samy Kashkoush Mohamad Almarastani Mohammed F. Shaheen Abdulrahman Altamimi Wael O’hali Khalid Bin Saad Lina Alnajjar Rawan Alhussein Raghad Almuhiteb Bashayr Alqahtani Rayana Alotaibi Marah Alqahtani Mohammed Tawhari Urinary Tract Infections in the First 6 Months after Renal Transplantation International Journal of Nephrology |
| title | Urinary Tract Infections in the First 6 Months after Renal Transplantation |
| title_full | Urinary Tract Infections in the First 6 Months after Renal Transplantation |
| title_fullStr | Urinary Tract Infections in the First 6 Months after Renal Transplantation |
| title_full_unstemmed | Urinary Tract Infections in the First 6 Months after Renal Transplantation |
| title_short | Urinary Tract Infections in the First 6 Months after Renal Transplantation |
| title_sort | urinary tract infections in the first 6 months after renal transplantation |
| url | http://dx.doi.org/10.1155/2021/3033276 |
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