Improving the Performance of Phase-Change Perfluorocarbon Droplets for Medical Ultrasonography: Current Progress, Challenges, and Prospects
Over the past two decades, perfluorocarbon (PFC) droplets have been investigated for biomedical applications across a wide range of imaging modalities. More recently, interest has increased in “phase-change” PFC droplets (or “phase-change” contrast agents), which can convert from liquid to gas with...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2014/579684 |
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| author | Paul S. Sheeran Paul A. Dayton |
| author_facet | Paul S. Sheeran Paul A. Dayton |
| author_sort | Paul S. Sheeran |
| collection | DOAJ |
| description | Over the past two decades, perfluorocarbon (PFC) droplets have been investigated for biomedical applications across a wide range of imaging modalities. More recently, interest has increased in “phase-change” PFC droplets (or “phase-change” contrast agents), which can convert from liquid to gas with an external energy input. In the field of ultrasound, phase-change droplets present an attractive alternative to traditional microbubble agents for many diagnostic and therapeutic applications. Despite the progress, phase-change PFC droplets remain far from clinical implementation due to a number of challenges. In this review, we survey our recent work to enhance the performance of phase-change agents for ultrasound through a variety of techniques in order to provide increased efficacy in therapeutic applications of ultrasound and enable previously unexplored applications in diagnostic and molecular imaging. |
| format | Article |
| id | doaj-art-43d18ba603c340f8b7436117f9a2630e |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-43d18ba603c340f8b7436117f9a2630e2025-02-03T01:10:44ZengWileyScientifica2090-908X2014-01-01201410.1155/2014/579684579684Improving the Performance of Phase-Change Perfluorocarbon Droplets for Medical Ultrasonography: Current Progress, Challenges, and ProspectsPaul S. Sheeran0Paul A. Dayton1Joint Department of Biomedical Engineering, The University of North Carolina and North Carolina State University, Chapel Hill, NC 27599, USAJoint Department of Biomedical Engineering, The University of North Carolina and North Carolina State University, Chapel Hill, NC 27599, USAOver the past two decades, perfluorocarbon (PFC) droplets have been investigated for biomedical applications across a wide range of imaging modalities. More recently, interest has increased in “phase-change” PFC droplets (or “phase-change” contrast agents), which can convert from liquid to gas with an external energy input. In the field of ultrasound, phase-change droplets present an attractive alternative to traditional microbubble agents for many diagnostic and therapeutic applications. Despite the progress, phase-change PFC droplets remain far from clinical implementation due to a number of challenges. In this review, we survey our recent work to enhance the performance of phase-change agents for ultrasound through a variety of techniques in order to provide increased efficacy in therapeutic applications of ultrasound and enable previously unexplored applications in diagnostic and molecular imaging.http://dx.doi.org/10.1155/2014/579684 |
| spellingShingle | Paul S. Sheeran Paul A. Dayton Improving the Performance of Phase-Change Perfluorocarbon Droplets for Medical Ultrasonography: Current Progress, Challenges, and Prospects Scientifica |
| title | Improving the Performance of Phase-Change Perfluorocarbon Droplets for Medical Ultrasonography: Current Progress, Challenges, and Prospects |
| title_full | Improving the Performance of Phase-Change Perfluorocarbon Droplets for Medical Ultrasonography: Current Progress, Challenges, and Prospects |
| title_fullStr | Improving the Performance of Phase-Change Perfluorocarbon Droplets for Medical Ultrasonography: Current Progress, Challenges, and Prospects |
| title_full_unstemmed | Improving the Performance of Phase-Change Perfluorocarbon Droplets for Medical Ultrasonography: Current Progress, Challenges, and Prospects |
| title_short | Improving the Performance of Phase-Change Perfluorocarbon Droplets for Medical Ultrasonography: Current Progress, Challenges, and Prospects |
| title_sort | improving the performance of phase change perfluorocarbon droplets for medical ultrasonography current progress challenges and prospects |
| url | http://dx.doi.org/10.1155/2014/579684 |
| work_keys_str_mv | AT paulssheeran improvingtheperformanceofphasechangeperfluorocarbondropletsformedicalultrasonographycurrentprogresschallengesandprospects AT pauladayton improvingtheperformanceofphasechangeperfluorocarbondropletsformedicalultrasonographycurrentprogresschallengesandprospects |