High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L.
Artemisia species are a rich source of herbal remedies with antioxidant and anti-inflammatory properties. We evaluated PMI-5011, an ethanolic extract of Artemisia dracunculus L., on neuropathy in high-sfat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and proinflammat...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/268547 |
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| _version_ | 1832549784197529600 |
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| author | Pierre Watcho Roman Stavniichuk David M. Ribnicky Ilya Raskin Irina G. Obrosova |
| author_facet | Pierre Watcho Roman Stavniichuk David M. Ribnicky Ilya Raskin Irina G. Obrosova |
| author_sort | Pierre Watcho |
| collection | DOAJ |
| description | Artemisia species are a rich source of herbal remedies with antioxidant and anti-inflammatory properties. We evaluated PMI-5011, an ethanolic extract of Artemisia dracunculus L., on neuropathy in high-sfat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and proinflammatory changes in peripheral nervous system. C57Bl6/J mice fed high-fat diet for 16 weeks developed obesity, moderate nonfasting hyperglycemia, nerve conduction deficit, thermal and mechanical hypoalgesia, and tactile allodynia. They displayed 12/15-lipoxygenase overexpression, 12(S)-hydroxyeicosatetraenoic acid accumulation, and nitrosative stress in peripheral nerve and spinal cord. PMI-5011 (500 mgkg-1d-1, 7 weeks) normalized glycemia, alleviated nerve conduction slowing and sensory neuropathy, and reduced 12/15-lipoxygenase upregulation and nitrated protein expression in peripheral nervous system. PMI-5011, a safe and nontoxic botanical extract, may find use in treatment of neuropathic changes at the earliest stage of disease. |
| format | Article |
| id | doaj-art-43bd45c0f6594ddb8cafde7c45023596 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-43bd45c0f6594ddb8cafde7c450235962025-02-03T06:08:36ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/268547268547High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L.Pierre Watcho0Roman Stavniichuk1David M. Ribnicky2Ilya Raskin3Irina G. Obrosova4Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USAPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USABiotech Center, Cook College, Rutgers University, New Brunswick, NJ 08901-8554, USABiotech Center, Cook College, Rutgers University, New Brunswick, NJ 08901-8554, USAPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USAArtemisia species are a rich source of herbal remedies with antioxidant and anti-inflammatory properties. We evaluated PMI-5011, an ethanolic extract of Artemisia dracunculus L., on neuropathy in high-sfat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and proinflammatory changes in peripheral nervous system. C57Bl6/J mice fed high-fat diet for 16 weeks developed obesity, moderate nonfasting hyperglycemia, nerve conduction deficit, thermal and mechanical hypoalgesia, and tactile allodynia. They displayed 12/15-lipoxygenase overexpression, 12(S)-hydroxyeicosatetraenoic acid accumulation, and nitrosative stress in peripheral nerve and spinal cord. PMI-5011 (500 mgkg-1d-1, 7 weeks) normalized glycemia, alleviated nerve conduction slowing and sensory neuropathy, and reduced 12/15-lipoxygenase upregulation and nitrated protein expression in peripheral nervous system. PMI-5011, a safe and nontoxic botanical extract, may find use in treatment of neuropathic changes at the earliest stage of disease.http://dx.doi.org/10.1155/2010/268547 |
| spellingShingle | Pierre Watcho Roman Stavniichuk David M. Ribnicky Ilya Raskin Irina G. Obrosova High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L. Mediators of Inflammation |
| title | High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L. |
| title_full | High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L. |
| title_fullStr | High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L. |
| title_full_unstemmed | High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L. |
| title_short | High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L. |
| title_sort | high fat diet induced neuropathy of prediabetes and obesity effect of pmi 5011 an ethanolic extract of artemisia dracunculus l |
| url | http://dx.doi.org/10.1155/2010/268547 |
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