Functional abnormalities of the glymphatic system in cognitive disorders
Various pathological mechanisms represent distinct therapeutic targets for cognitive disorders, but a balance between clearance and production is essential for maintaining the stability of the brain’s internal environment. Thus, the glymphatic system may represent a common pathway by which to addres...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-12-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/NRR.NRR-D-24-01049 |
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| author | Wuyue Shentu Qi Kong Yier Zhang Wenyao Li Qiulu Chen Sicheng Yan Junjun Wang Qilun Lai Qi Xu Song Qiao |
| author_facet | Wuyue Shentu Qi Kong Yier Zhang Wenyao Li Qiulu Chen Sicheng Yan Junjun Wang Qilun Lai Qi Xu Song Qiao |
| author_sort | Wuyue Shentu |
| collection | DOAJ |
| description | Various pathological mechanisms represent distinct therapeutic targets for cognitive disorders, but a balance between clearance and production is essential for maintaining the stability of the brain’s internal environment. Thus, the glymphatic system may represent a common pathway by which to address cognitive disorders. Using the established model of the glymphatic system as our foundation, this review disentangles and analyzes the components of its clearance mechanism, including the initial inflow of cerebrospinal fluid, the mixing of cerebrospinal fluid with interstitial fluid, and the outflow of the mixed fluid and the clearance. Each section summarizes evidence from experimental animal models and human studies, highlighting the normal physiological properties of key structures alongside their pathological manifestations in cognitive disorders. The same pathologic manifestations of different cognitive disorders appearing in the glymphatic system and the same upstream influences are main points of interest of this review. We conclude this article by discussing new findings and outlining the limitations identified in current research progress. |
| format | Article |
| id | doaj-art-43bb59929fd6432bbbbb37f3fb771d9c |
| institution | Kabale University |
| issn | 1673-5374 1876-7958 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj-art-43bb59929fd6432bbbbb37f3fb771d9c2025-02-06T09:58:38ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53741876-79582025-12-0120123430344710.4103/NRR.NRR-D-24-01049Functional abnormalities of the glymphatic system in cognitive disordersWuyue ShentuQi KongYier ZhangWenyao LiQiulu ChenSicheng YanJunjun WangQilun LaiQi XuSong QiaoVarious pathological mechanisms represent distinct therapeutic targets for cognitive disorders, but a balance between clearance and production is essential for maintaining the stability of the brain’s internal environment. Thus, the glymphatic system may represent a common pathway by which to address cognitive disorders. Using the established model of the glymphatic system as our foundation, this review disentangles and analyzes the components of its clearance mechanism, including the initial inflow of cerebrospinal fluid, the mixing of cerebrospinal fluid with interstitial fluid, and the outflow of the mixed fluid and the clearance. Each section summarizes evidence from experimental animal models and human studies, highlighting the normal physiological properties of key structures alongside their pathological manifestations in cognitive disorders. The same pathologic manifestations of different cognitive disorders appearing in the glymphatic system and the same upstream influences are main points of interest of this review. We conclude this article by discussing new findings and outlining the limitations identified in current research progress.https://journals.lww.com/10.4103/NRR.NRR-D-24-01049aquaporin-4astrocytecerebrospinal fluid dynamicscognitive disordersglymphatic system |
| spellingShingle | Wuyue Shentu Qi Kong Yier Zhang Wenyao Li Qiulu Chen Sicheng Yan Junjun Wang Qilun Lai Qi Xu Song Qiao Functional abnormalities of the glymphatic system in cognitive disorders Neural Regeneration Research aquaporin-4 astrocyte cerebrospinal fluid dynamics cognitive disorders glymphatic system |
| title | Functional abnormalities of the glymphatic system in cognitive disorders |
| title_full | Functional abnormalities of the glymphatic system in cognitive disorders |
| title_fullStr | Functional abnormalities of the glymphatic system in cognitive disorders |
| title_full_unstemmed | Functional abnormalities of the glymphatic system in cognitive disorders |
| title_short | Functional abnormalities of the glymphatic system in cognitive disorders |
| title_sort | functional abnormalities of the glymphatic system in cognitive disorders |
| topic | aquaporin-4 astrocyte cerebrospinal fluid dynamics cognitive disorders glymphatic system |
| url | https://journals.lww.com/10.4103/NRR.NRR-D-24-01049 |
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