Ripples Make Waves: Binding Structured Activity and Plasticity in Hippocampal Networks
Establishing novel episodic memories and stable spatial representations depends on an exquisitely choreographed, multistage process involving the online encoding and offline consolidation of sensory information, a process that is largely dependent on the hippocampus. Each step is influenced by disti...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2011/960389 |
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| author | Josef H. L. P. Sadowski Matthew W. Jones Jack R. Mellor |
| author_facet | Josef H. L. P. Sadowski Matthew W. Jones Jack R. Mellor |
| author_sort | Josef H. L. P. Sadowski |
| collection | DOAJ |
| description | Establishing novel episodic memories and stable spatial representations depends on an exquisitely choreographed, multistage process involving the online encoding and offline consolidation of sensory information, a process that is largely dependent on the hippocampus. Each step is influenced by distinct neural network states that influence the pattern of activation across cellular assemblies. In recent years, the occurrence of hippocampal sharp wave ripple (SWR) oscillations has emerged as a potentially vital network phenomenon mediating the steps between encoding and consolidation, both at a cellular and network level by promoting the rapid replay and reactivation of recent activity patterns. Such events facilitate memory formation by optimising the conditions for synaptic plasticity to occur between contingent neural elements. In this paper, we explore the ways in which SWRs and other network events can bridge the gap between spatiomnemonic processing at cellular/synaptic and network levels in the hippocampus. |
| format | Article |
| id | doaj-art-43ac39e80127477e9b1cfe2ad2509654 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-43ac39e80127477e9b1cfe2ad25096542025-02-03T06:12:22ZengWileyNeural Plasticity2090-59041687-54432011-01-01201110.1155/2011/960389960389Ripples Make Waves: Binding Structured Activity and Plasticity in Hippocampal NetworksJosef H. L. P. Sadowski0Matthew W. Jones1Jack R. Mellor2MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol BS8 1TD, UKMRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol BS8 1TD, UKMRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol BS8 1TD, UKEstablishing novel episodic memories and stable spatial representations depends on an exquisitely choreographed, multistage process involving the online encoding and offline consolidation of sensory information, a process that is largely dependent on the hippocampus. Each step is influenced by distinct neural network states that influence the pattern of activation across cellular assemblies. In recent years, the occurrence of hippocampal sharp wave ripple (SWR) oscillations has emerged as a potentially vital network phenomenon mediating the steps between encoding and consolidation, both at a cellular and network level by promoting the rapid replay and reactivation of recent activity patterns. Such events facilitate memory formation by optimising the conditions for synaptic plasticity to occur between contingent neural elements. In this paper, we explore the ways in which SWRs and other network events can bridge the gap between spatiomnemonic processing at cellular/synaptic and network levels in the hippocampus.http://dx.doi.org/10.1155/2011/960389 |
| spellingShingle | Josef H. L. P. Sadowski Matthew W. Jones Jack R. Mellor Ripples Make Waves: Binding Structured Activity and Plasticity in Hippocampal Networks Neural Plasticity |
| title | Ripples Make Waves: Binding Structured Activity and Plasticity in Hippocampal Networks |
| title_full | Ripples Make Waves: Binding Structured Activity and Plasticity in Hippocampal Networks |
| title_fullStr | Ripples Make Waves: Binding Structured Activity and Plasticity in Hippocampal Networks |
| title_full_unstemmed | Ripples Make Waves: Binding Structured Activity and Plasticity in Hippocampal Networks |
| title_short | Ripples Make Waves: Binding Structured Activity and Plasticity in Hippocampal Networks |
| title_sort | ripples make waves binding structured activity and plasticity in hippocampal networks |
| url | http://dx.doi.org/10.1155/2011/960389 |
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