Ex vivo-generated lymphoid progenitors encompass both T cell and innate lymphoid cell fates

Ex vivo-generated lymphoid progenitors encompass both T cell and innate lymphoid cell fates

IntroductionWe previously established a feeder-free cell therapy platform for the ex vivo generation of lymphoid-primed progenitors using immobilized Delta-like ligand 4 (DLL4). In vivo studies demonstrated that adoptive transfer of these progenitors accelerates T cell reconstitution following thymi...

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Main Authors: Pierre Gaudeaux, Juliette Paillet, Monah Abou Alezz, Ranjita Devi Moirangthem, Sara Cascione, Marta Martin Corredera, Anne-Catherine Dolens, Katrien De Mulder, Imke Velghe, Bart Vandekerckhove, Marieke Lavaert, Noémie Robil, Aurélien Corneau, Hanem Sadek, Pauline Rault, Akshay Joshi, Pierre de la Grange, Frank J. T. Staal, Tom Taghon, Olivier Negre, Andrea Ditadi, Isabelle André, Tayebeh-Shabi Soheili
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
T cell progenitors
lymphoid cell development
scRNAseq
ex vivo differentiation
hematopoietic stem cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617707/full
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