Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A Case-Control Study
Background. Adipocytokines participate in regulating the inflammatory response in glucose homeostasis and type 2 diabetes. However, among these peptides, the role of adipocyte-specific fatty-acid-binding protein (AFABP), chemerin, and secreted protein acidic and rich in cysteine (SPARC) in gestation...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/5533802 |
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| author | Maryam Mosavat Mitra Mirsanjari Bashir A. Lwaleed Maherah Kamarudin Siti Zawiah Omar |
| author_facet | Maryam Mosavat Mitra Mirsanjari Bashir A. Lwaleed Maherah Kamarudin Siti Zawiah Omar |
| author_sort | Maryam Mosavat |
| collection | DOAJ |
| description | Background. Adipocytokines participate in regulating the inflammatory response in glucose homeostasis and type 2 diabetes. However, among these peptides, the role of adipocyte-specific fatty-acid-binding protein (AFABP), chemerin, and secreted protein acidic and rich in cysteine (SPARC) in gestational diabetes (GDM) has not been fully investigated. Method. The maternal fasting level of adipocytokines of 53 subjects with GDM and 43 normal pregnant (NGDM) was measured using multiplex immunoassay at 24–28 weeks, before delivery, immediate postpartum, and 2–6 months postpuerperium. Results. Higher levels of AFABP were associated with a 3.7-fold higher risk of GDM. Low chemerin levels were associated with a 3.6-fold higher risk of GDM. Interleukin-10 (IL-10) was inversely associated with the risk of GDM. SPARC had no association with GDM. AFABP was directly correlated to interleukin-6 (r=0.50), insulin resistance index (r=0.26), and body mass index (r=0.28) and inversely correlated to C-reactive protein (r=−0.27). Chemerin levels were directly and strongly correlated with IL-10 (r=0.41) and interleukin-4 (r=0.50) and inversely correlated to insulin resistance index (r=−0.23) in GDM but not NGDM. In the longitudinal assessment, there were no significant differences in AFABP and chemerin concentrations of both studied groups. Conclusion. AFABP and chemerin were associated with a higher risk of GDM. These adipocytokines were related to insulin resistance, body mass index, and inflammation in pregnant women diagnosed with GDM. |
| format | Article |
| id | doaj-art-43a1125527974439b9c64ac5be1860cb |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-43a1125527974439b9c64ac5be1860cb2025-02-03T06:05:27ZengWileyJournal of Diabetes Research2314-67452314-67532021-01-01202110.1155/2021/55338025533802Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A Case-Control StudyMaryam Mosavat0Mitra Mirsanjari1Bashir A. Lwaleed2Maherah Kamarudin3Siti Zawiah Omar4Department of Obstetrics & Gynecology, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaMazandaran University of Medical Sciences, Emam Khomeini Hospital, Fereidonkenar, Mazandaran, IranSchool of Health Sciences at the University of Southampton, UKDepartment of Obstetrics & Gynecology, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaDepartment of Obstetrics & Gynecology, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaBackground. Adipocytokines participate in regulating the inflammatory response in glucose homeostasis and type 2 diabetes. However, among these peptides, the role of adipocyte-specific fatty-acid-binding protein (AFABP), chemerin, and secreted protein acidic and rich in cysteine (SPARC) in gestational diabetes (GDM) has not been fully investigated. Method. The maternal fasting level of adipocytokines of 53 subjects with GDM and 43 normal pregnant (NGDM) was measured using multiplex immunoassay at 24–28 weeks, before delivery, immediate postpartum, and 2–6 months postpuerperium. Results. Higher levels of AFABP were associated with a 3.7-fold higher risk of GDM. Low chemerin levels were associated with a 3.6-fold higher risk of GDM. Interleukin-10 (IL-10) was inversely associated with the risk of GDM. SPARC had no association with GDM. AFABP was directly correlated to interleukin-6 (r=0.50), insulin resistance index (r=0.26), and body mass index (r=0.28) and inversely correlated to C-reactive protein (r=−0.27). Chemerin levels were directly and strongly correlated with IL-10 (r=0.41) and interleukin-4 (r=0.50) and inversely correlated to insulin resistance index (r=−0.23) in GDM but not NGDM. In the longitudinal assessment, there were no significant differences in AFABP and chemerin concentrations of both studied groups. Conclusion. AFABP and chemerin were associated with a higher risk of GDM. These adipocytokines were related to insulin resistance, body mass index, and inflammation in pregnant women diagnosed with GDM.http://dx.doi.org/10.1155/2021/5533802 |
| spellingShingle | Maryam Mosavat Mitra Mirsanjari Bashir A. Lwaleed Maherah Kamarudin Siti Zawiah Omar Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A Case-Control Study Journal of Diabetes Research |
| title | Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A Case-Control Study |
| title_full | Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A Case-Control Study |
| title_fullStr | Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A Case-Control Study |
| title_full_unstemmed | Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A Case-Control Study |
| title_short | Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A Case-Control Study |
| title_sort | adipocyte specific fatty acid binding protein afabp and chemerin in association with gestational diabetes a case control study |
| url | http://dx.doi.org/10.1155/2021/5533802 |
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