Enantioselective Potentiometric Membrane Electrodes Based on Antibiotics for the Determination of L- and D-Glyceric Acids
Glyceric acid (GA) is a human metabolite existing in L- and D-configurations, which are considered the markers for the diseases L- and D-glyceric aciduria/academia, respectively. Enantioselective, potentiometric membrane electrodes based on carbon paste modified with antibiotics as chiral selectors,...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Electrochemistry |
| Online Access: | http://dx.doi.org/10.4061/2011/427238 |
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| author | Raluca-Ioana Stefan-van Staden R'afat M. Nejem Jacobus Frederick van Staden Hassan Y. Aboul-Enein |
| author_facet | Raluca-Ioana Stefan-van Staden R'afat M. Nejem Jacobus Frederick van Staden Hassan Y. Aboul-Enein |
| author_sort | Raluca-Ioana Stefan-van Staden |
| collection | DOAJ |
| description | Glyceric acid (GA) is a human metabolite existing in L- and D-configurations, which are considered the markers for the diseases L- and D-glyceric aciduria/academia, respectively. Enantioselective, potentiometric membrane electrodes based on carbon paste modified with antibiotics as chiral selectors, vancomycin, and teicoplanin were designed for the assay of L- and D-GA, respectively, in the concentration ranges of 10−9–10−7 and 10−4–10−2 moL/L with very low detection limits (1.5 × 10−10 moL/L for L-GA and 1.6 × 10−4 moL/L for D-GA, resp.). The surface of the electrodes can be regenerated simply by polishing in order to obtain a fresh surface ready to be used in a new assay. The proposed electrodes can be successfully applied for the enantioanalysis of L- and D-glyceric acids in serum samples. |
| format | Article |
| id | doaj-art-439f9237d4114599bc6cd10314273695 |
| institution | Kabale University |
| issn | 2090-3537 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Electrochemistry |
| spelling | doaj-art-439f9237d4114599bc6cd103142736952025-02-03T05:58:41ZengWileyInternational Journal of Electrochemistry2090-35372011-01-01201110.4061/2011/427238427238Enantioselective Potentiometric Membrane Electrodes Based on Antibiotics for the Determination of L- and D-Glyceric AcidsRaluca-Ioana Stefan-van Staden0R'afat M. Nejem1Jacobus Frederick van Staden2Hassan Y. Aboul-Enein3Laboratory of Electrochemistry and PATLAB Bucharest, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Strada, 060021 Bucharest, RomaniaDepartment of Chemistry, Al-Aqsa University, Gaza, PalestineLaboratory of Electrochemistry and PATLAB Bucharest, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Strada, 060021 Bucharest, RomaniaThe Pharmaceutical and Drug Industries Research Division, Pharmaceutical and Medicinal Chemistry Department, National Research Centre, Dokki, Cairo 12311, EgyptGlyceric acid (GA) is a human metabolite existing in L- and D-configurations, which are considered the markers for the diseases L- and D-glyceric aciduria/academia, respectively. Enantioselective, potentiometric membrane electrodes based on carbon paste modified with antibiotics as chiral selectors, vancomycin, and teicoplanin were designed for the assay of L- and D-GA, respectively, in the concentration ranges of 10−9–10−7 and 10−4–10−2 moL/L with very low detection limits (1.5 × 10−10 moL/L for L-GA and 1.6 × 10−4 moL/L for D-GA, resp.). The surface of the electrodes can be regenerated simply by polishing in order to obtain a fresh surface ready to be used in a new assay. The proposed electrodes can be successfully applied for the enantioanalysis of L- and D-glyceric acids in serum samples.http://dx.doi.org/10.4061/2011/427238 |
| spellingShingle | Raluca-Ioana Stefan-van Staden R'afat M. Nejem Jacobus Frederick van Staden Hassan Y. Aboul-Enein Enantioselective Potentiometric Membrane Electrodes Based on Antibiotics for the Determination of L- and D-Glyceric Acids International Journal of Electrochemistry |
| title | Enantioselective Potentiometric Membrane Electrodes Based on Antibiotics for the Determination of L- and D-Glyceric Acids |
| title_full | Enantioselective Potentiometric Membrane Electrodes Based on Antibiotics for the Determination of L- and D-Glyceric Acids |
| title_fullStr | Enantioselective Potentiometric Membrane Electrodes Based on Antibiotics for the Determination of L- and D-Glyceric Acids |
| title_full_unstemmed | Enantioselective Potentiometric Membrane Electrodes Based on Antibiotics for the Determination of L- and D-Glyceric Acids |
| title_short | Enantioselective Potentiometric Membrane Electrodes Based on Antibiotics for the Determination of L- and D-Glyceric Acids |
| title_sort | enantioselective potentiometric membrane electrodes based on antibiotics for the determination of l and d glyceric acids |
| url | http://dx.doi.org/10.4061/2011/427238 |
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