Polynitrogen Bicyclic and Tricyclic Compounds as PDE4 Inhibitors

Polynitrogen Bicyclic and Tricyclic Compounds as PDE4 Inhibitors

We report here two new series of designed PDE4 inhibitors, the first one showing the quinoline scaffold recently investigated by us through a fragment-based drug design strategy, and the second consisting of pyrazolo [1′,5′:1,6]pyrimido[4,5-<i>d</i>]pyridazine derivatives. Both the new s...

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Bibliographic Details
Main Authors: Claudia Vergelli, Agostino Cilibrizzi, Gabriella Guerrini, Fabrizio Melani, Marta Menicatti, Gianluca Bartolucci, Maria Paola Giovannoni, Letizia Crocetti
Format: Article
Language:English
Published: MDPI AG 2025-08-01
Series:Applied Sciences
Subjects:
Quinolines
pyrazolo [1′,5′:1,6]pyrimido [4,5-<i>d</i>]pyridazines
synthesis
phosphodiesterase 4 (PDE4)
inhibitors
Online Access:https://www.mdpi.com/2076-3417/15/15/8678
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