The Use of Sodium Bicarbonate in the Treatment of Acidosis in Sepsis: A Literature Update on a Long Term Debate
Introduction. Sepsis and its consequences such as metabolic acidosis are resulting in increased mortality. Although correction of metabolic acidosis with sodium bicarbonate seems a reasonable approach, there is ongoing debate regarding the role of bicarbonates as a therapeutic option. Methods. We co...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/605830 |
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| author | Dimitrios Velissaris Vasilios Karamouzos Nikolaos Ktenopoulos Charalampos Pierrakos Menelaos Karanikolas |
| author_facet | Dimitrios Velissaris Vasilios Karamouzos Nikolaos Ktenopoulos Charalampos Pierrakos Menelaos Karanikolas |
| author_sort | Dimitrios Velissaris |
| collection | DOAJ |
| description | Introduction. Sepsis and its consequences such as metabolic acidosis are resulting in increased mortality. Although correction of metabolic acidosis with sodium bicarbonate seems a reasonable approach, there is ongoing debate regarding the role of bicarbonates as a therapeutic option. Methods. We conducted a PubMed literature search in order to identify published literature related to the effects of sodium bicarbonate treatment on metabolic acidosis due to sepsis. The search included all articles published in English in the last 35 years. Results. There is ongoing debate regarding the use of bicarbonates for the treatment of acidosis in sepsis, but there is a trend towards not using bicarbonate in sepsis patients with arterial blood gas pH>7.15. Conclusions. Routine use of bicarbonate for treatment of severe acidemia and lactic acidosis due to sepsis is subject of controversy, and current opinion does not favor routine use of bicarbonates. However, available evidence is inconclusive, and more studies are required to determine the potential benefit, if any, of bicarbonate therapy in the sepsis patient with acidosis. |
| format | Article |
| id | doaj-art-4389df199e7245028e45eb6f748a43e0 |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-4389df199e7245028e45eb6f748a43e02025-02-03T05:57:52ZengWileyCritical Care Research and Practice2090-13052090-13132015-01-01201510.1155/2015/605830605830The Use of Sodium Bicarbonate in the Treatment of Acidosis in Sepsis: A Literature Update on a Long Term DebateDimitrios Velissaris0Vasilios Karamouzos1Nikolaos Ktenopoulos2Charalampos Pierrakos3Menelaos Karanikolas4Internal Medicine Department, University Hospital of Patras, 26500 Rion, GreeceInternal Medicine Department, University Hospital of Patras, 26500 Rion, GreeceInternal Medicine Department, University Hospital of Patras, 26500 Rion, GreeceIntensive Care Department, Brugmann University Hospital, 1030 Brussels, BelgiumDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USAIntroduction. Sepsis and its consequences such as metabolic acidosis are resulting in increased mortality. Although correction of metabolic acidosis with sodium bicarbonate seems a reasonable approach, there is ongoing debate regarding the role of bicarbonates as a therapeutic option. Methods. We conducted a PubMed literature search in order to identify published literature related to the effects of sodium bicarbonate treatment on metabolic acidosis due to sepsis. The search included all articles published in English in the last 35 years. Results. There is ongoing debate regarding the use of bicarbonates for the treatment of acidosis in sepsis, but there is a trend towards not using bicarbonate in sepsis patients with arterial blood gas pH>7.15. Conclusions. Routine use of bicarbonate for treatment of severe acidemia and lactic acidosis due to sepsis is subject of controversy, and current opinion does not favor routine use of bicarbonates. However, available evidence is inconclusive, and more studies are required to determine the potential benefit, if any, of bicarbonate therapy in the sepsis patient with acidosis.http://dx.doi.org/10.1155/2015/605830 |
| spellingShingle | Dimitrios Velissaris Vasilios Karamouzos Nikolaos Ktenopoulos Charalampos Pierrakos Menelaos Karanikolas The Use of Sodium Bicarbonate in the Treatment of Acidosis in Sepsis: A Literature Update on a Long Term Debate Critical Care Research and Practice |
| title | The Use of Sodium Bicarbonate in the Treatment of Acidosis in Sepsis: A Literature Update on a Long Term Debate |
| title_full | The Use of Sodium Bicarbonate in the Treatment of Acidosis in Sepsis: A Literature Update on a Long Term Debate |
| title_fullStr | The Use of Sodium Bicarbonate in the Treatment of Acidosis in Sepsis: A Literature Update on a Long Term Debate |
| title_full_unstemmed | The Use of Sodium Bicarbonate in the Treatment of Acidosis in Sepsis: A Literature Update on a Long Term Debate |
| title_short | The Use of Sodium Bicarbonate in the Treatment of Acidosis in Sepsis: A Literature Update on a Long Term Debate |
| title_sort | use of sodium bicarbonate in the treatment of acidosis in sepsis a literature update on a long term debate |
| url | http://dx.doi.org/10.1155/2015/605830 |
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