Rat Brain Normalization Templates for Robust Regional Analysis of [C]ABP688 Positron Emission Tomography/Computed Tomography
A methodology to generate rat brain templates for spatial normalization of positron emission tomographic (PET)/computed tomographic (CT) images is described and applied to generate three different templates for imaging of [ 11 C]ABP688, a PET ligand binding to the metabotropic glutamate 5 receptor....
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-01-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2014.00037 |
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| _version_ | 1832544474241171456 |
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| author | Jeroen Verhaeghe Leonie Wyffels Tine Wyckhuys Sigrid Stroobants Steven Staelens |
| author_facet | Jeroen Verhaeghe Leonie Wyffels Tine Wyckhuys Sigrid Stroobants Steven Staelens |
| author_sort | Jeroen Verhaeghe |
| collection | DOAJ |
| description | A methodology to generate rat brain templates for spatial normalization of positron emission tomographic (PET)/computed tomographic (CT) images is described and applied to generate three different templates for imaging of [ 11 C]ABP688, a PET ligand binding to the metabotropic glutamate 5 receptor. The templates are based on functional (PET), structural (CT), and combined PET and CT information, respectively. The templates are created from a test–retest study under normal conditions and are used to assess the different templates by using them in the analysis pipeline of a test–retest and a blocking experiment. The resulting average nondisplaceable binding potentials (BP ND ) show significant (analysis of variance, p < .05) and substantial (up to 23%) differences between the different approaches in several brain regions. The highest BP ND values in receptor-rich regions are obtained using the PET-based approach. This approach also had the smallest variability in all tested regions (standard error of measurement of 9% versus 14% [PET/CT] and 20% [CT]). All approaches showed similar relative changes in BP ND values with increased blocking. Taken together, these results suggest that the use of the tracer-specific PET-based template outperforms the other approaches with the performance of the combined PET/CT template between those of the PET and the tracer-independent CT template. |
| format | Article |
| id | doaj-art-4389de2fad1a4b638a5cd3104e115956 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-4389de2fad1a4b638a5cd3104e1159562025-02-03T10:12:57ZengSAGE PublishingMolecular Imaging1536-01212015-01-011410.2310/7290.2014.0003710.2310_7290.2014.00037Rat Brain Normalization Templates for Robust Regional Analysis of [C]ABP688 Positron Emission Tomography/Computed TomographyJeroen VerhaegheLeonie WyffelsTine WyckhuysSigrid StroobantsSteven StaelensA methodology to generate rat brain templates for spatial normalization of positron emission tomographic (PET)/computed tomographic (CT) images is described and applied to generate three different templates for imaging of [ 11 C]ABP688, a PET ligand binding to the metabotropic glutamate 5 receptor. The templates are based on functional (PET), structural (CT), and combined PET and CT information, respectively. The templates are created from a test–retest study under normal conditions and are used to assess the different templates by using them in the analysis pipeline of a test–retest and a blocking experiment. The resulting average nondisplaceable binding potentials (BP ND ) show significant (analysis of variance, p < .05) and substantial (up to 23%) differences between the different approaches in several brain regions. The highest BP ND values in receptor-rich regions are obtained using the PET-based approach. This approach also had the smallest variability in all tested regions (standard error of measurement of 9% versus 14% [PET/CT] and 20% [CT]). All approaches showed similar relative changes in BP ND values with increased blocking. Taken together, these results suggest that the use of the tracer-specific PET-based template outperforms the other approaches with the performance of the combined PET/CT template between those of the PET and the tracer-independent CT template.https://doi.org/10.2310/7290.2014.00037 |
| spellingShingle | Jeroen Verhaeghe Leonie Wyffels Tine Wyckhuys Sigrid Stroobants Steven Staelens Rat Brain Normalization Templates for Robust Regional Analysis of [C]ABP688 Positron Emission Tomography/Computed Tomography Molecular Imaging |
| title | Rat Brain Normalization Templates for Robust Regional Analysis of [C]ABP688 Positron Emission Tomography/Computed Tomography |
| title_full | Rat Brain Normalization Templates for Robust Regional Analysis of [C]ABP688 Positron Emission Tomography/Computed Tomography |
| title_fullStr | Rat Brain Normalization Templates for Robust Regional Analysis of [C]ABP688 Positron Emission Tomography/Computed Tomography |
| title_full_unstemmed | Rat Brain Normalization Templates for Robust Regional Analysis of [C]ABP688 Positron Emission Tomography/Computed Tomography |
| title_short | Rat Brain Normalization Templates for Robust Regional Analysis of [C]ABP688 Positron Emission Tomography/Computed Tomography |
| title_sort | rat brain normalization templates for robust regional analysis of c abp688 positron emission tomography computed tomography |
| url | https://doi.org/10.2310/7290.2014.00037 |
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