Molecular Evidence of Coinfection with Acute Respiratory Viruses and High Prevalence of SARS-CoV-2 among Patients Presenting Flu-Like Illness in Bukavu City, Democratic Republic of Congo
The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with clinical manifestation cases that are almost similar to those of common respiratory viral infections. This study determined the prevalence of SARS-CoV-2 and other acute respiratory...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2022/1553266 |
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| author | Patrick Bisimwa Ntagereka Rodrigue Ayagirwe Basengere Tshass Chasinga Baharanyi Théophile Mitima Kashosi Jean-Paul Chikwanine Buhendwa Parvine Basimane Bisimwa Aline Byabene Kusinza Yannick Mugumaarhahama Dieudonne Wasso Shukuru Simon Baenyi Patrick Ronald Tonui Ahadi Bwihangane Birindwa Denis Mukwege |
| author_facet | Patrick Bisimwa Ntagereka Rodrigue Ayagirwe Basengere Tshass Chasinga Baharanyi Théophile Mitima Kashosi Jean-Paul Chikwanine Buhendwa Parvine Basimane Bisimwa Aline Byabene Kusinza Yannick Mugumaarhahama Dieudonne Wasso Shukuru Simon Baenyi Patrick Ronald Tonui Ahadi Bwihangane Birindwa Denis Mukwege |
| author_sort | Patrick Bisimwa Ntagereka |
| collection | DOAJ |
| description | The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with clinical manifestation cases that are almost similar to those of common respiratory viral infections. This study determined the prevalence of SARS-CoV-2 and other acute respiratory viruses among patients with flu-like symptoms in Bukavu city, Democratic Republic of Congo. We screened 1352 individuals with flu-like illnesses seeking treatment in 10 health facilities. Nasopharyngeal swab specimens were collected to detect SARS-CoV-2 using real-time reverse transcription-polymerase chain reaction (RT-PCR), and 10 common respiratory viruses were detected by multiplex reverse transcription-polymerase chain reaction assay. Overall, 13.9% (188/1352) of patients were confirmed positive for SARS-CoV-2. Influenza A 5.6% (56/1352) and Influenza B 0.9% (12/1352) were the most common respiratory viruses detected. Overall, more than two cases of the other acute respiratory viruses were detected. Frequently observed symptoms associated with SARS-CoV-2 positivity were shivering (47.8%; OR = 1.8; CI: 0.88–1.35), cough (89.6%; OR = 6.5, CI: 2.16–28.2), and myalgia and dizziness (59.7%; OR = 2.7; CI: 1.36–5.85). Moreover, coinfection was observed in 12 (11.5%) specimens. SARS-CoV-2 and influenza A were the most cooccurring infections, accounting for 33.3% of all positive cases. This study demonstrates cases of COVID-19 infections cooccurring with other acute respiratory infections in Bukavu city during the ongoing outbreak of COVID-19. Therefore, testing for respiratory viruses should be performed in all patients with flu-like symptoms for effective surveillance of the transmission patterns in the COVID-19 affected areas for optimal treatment and effective disease management. |
| format | Article |
| id | doaj-art-438390333e074cd8adbbd01884d4b72a |
| institution | Kabale University |
| issn | 1918-1493 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-438390333e074cd8adbbd01884d4b72a2025-02-03T07:24:17ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1918-14932022-01-01202210.1155/2022/1553266Molecular Evidence of Coinfection with Acute Respiratory Viruses and High Prevalence of SARS-CoV-2 among Patients Presenting Flu-Like Illness in Bukavu City, Democratic Republic of CongoPatrick Bisimwa Ntagereka0Rodrigue Ayagirwe Basengere1Tshass Chasinga Baharanyi2Théophile Mitima Kashosi3Jean-Paul Chikwanine Buhendwa4Parvine Basimane Bisimwa5Aline Byabene Kusinza6Yannick Mugumaarhahama7Dieudonne Wasso Shukuru8Simon Baenyi Patrick9Ronald Tonui10Ahadi Bwihangane Birindwa11Denis Mukwege12Molecular Biology LaboratoryMolecular Biology LaboratoryFaculty of MedicineMolecular Biology LaboratoryFaculty of MedicineFaculty of MedicineFaculty of MedicineMolecular Biology LaboratoryMolecular Biology LaboratoryMolecular Biology LaboratoryInstitute of Basic SciencesMolecular Biology LaboratoryFaculty of MedicineThe coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with clinical manifestation cases that are almost similar to those of common respiratory viral infections. This study determined the prevalence of SARS-CoV-2 and other acute respiratory viruses among patients with flu-like symptoms in Bukavu city, Democratic Republic of Congo. We screened 1352 individuals with flu-like illnesses seeking treatment in 10 health facilities. Nasopharyngeal swab specimens were collected to detect SARS-CoV-2 using real-time reverse transcription-polymerase chain reaction (RT-PCR), and 10 common respiratory viruses were detected by multiplex reverse transcription-polymerase chain reaction assay. Overall, 13.9% (188/1352) of patients were confirmed positive for SARS-CoV-2. Influenza A 5.6% (56/1352) and Influenza B 0.9% (12/1352) were the most common respiratory viruses detected. Overall, more than two cases of the other acute respiratory viruses were detected. Frequently observed symptoms associated with SARS-CoV-2 positivity were shivering (47.8%; OR = 1.8; CI: 0.88–1.35), cough (89.6%; OR = 6.5, CI: 2.16–28.2), and myalgia and dizziness (59.7%; OR = 2.7; CI: 1.36–5.85). Moreover, coinfection was observed in 12 (11.5%) specimens. SARS-CoV-2 and influenza A were the most cooccurring infections, accounting for 33.3% of all positive cases. This study demonstrates cases of COVID-19 infections cooccurring with other acute respiratory infections in Bukavu city during the ongoing outbreak of COVID-19. Therefore, testing for respiratory viruses should be performed in all patients with flu-like symptoms for effective surveillance of the transmission patterns in the COVID-19 affected areas for optimal treatment and effective disease management.http://dx.doi.org/10.1155/2022/1553266 |
| spellingShingle | Patrick Bisimwa Ntagereka Rodrigue Ayagirwe Basengere Tshass Chasinga Baharanyi Théophile Mitima Kashosi Jean-Paul Chikwanine Buhendwa Parvine Basimane Bisimwa Aline Byabene Kusinza Yannick Mugumaarhahama Dieudonne Wasso Shukuru Simon Baenyi Patrick Ronald Tonui Ahadi Bwihangane Birindwa Denis Mukwege Molecular Evidence of Coinfection with Acute Respiratory Viruses and High Prevalence of SARS-CoV-2 among Patients Presenting Flu-Like Illness in Bukavu City, Democratic Republic of Congo Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Molecular Evidence of Coinfection with Acute Respiratory Viruses and High Prevalence of SARS-CoV-2 among Patients Presenting Flu-Like Illness in Bukavu City, Democratic Republic of Congo |
| title_full | Molecular Evidence of Coinfection with Acute Respiratory Viruses and High Prevalence of SARS-CoV-2 among Patients Presenting Flu-Like Illness in Bukavu City, Democratic Republic of Congo |
| title_fullStr | Molecular Evidence of Coinfection with Acute Respiratory Viruses and High Prevalence of SARS-CoV-2 among Patients Presenting Flu-Like Illness in Bukavu City, Democratic Republic of Congo |
| title_full_unstemmed | Molecular Evidence of Coinfection with Acute Respiratory Viruses and High Prevalence of SARS-CoV-2 among Patients Presenting Flu-Like Illness in Bukavu City, Democratic Republic of Congo |
| title_short | Molecular Evidence of Coinfection with Acute Respiratory Viruses and High Prevalence of SARS-CoV-2 among Patients Presenting Flu-Like Illness in Bukavu City, Democratic Republic of Congo |
| title_sort | molecular evidence of coinfection with acute respiratory viruses and high prevalence of sars cov 2 among patients presenting flu like illness in bukavu city democratic republic of congo |
| url | http://dx.doi.org/10.1155/2022/1553266 |
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