B and NK Cells Closely Correlate with the Condition of Patients with Acute Pancreatitis
Purpose. Pancreatitis can lead to systemic inflammatory response, but the relationship between lymphocyte changes and patients with pancreatitis remains unclear. In this study, we evaluated the feedback function of changes in peripheral lymphocyte subsets on the condition of patients with pancreatit...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/7568410 |
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| author | Xin Wei Weifeng Yao Huiping Li Jingjing Qian Yaosheng Xie Zhuo Zhang Hong Lu Liang Shi Xiangyang Lin |
| author_facet | Xin Wei Weifeng Yao Huiping Li Jingjing Qian Yaosheng Xie Zhuo Zhang Hong Lu Liang Shi Xiangyang Lin |
| author_sort | Xin Wei |
| collection | DOAJ |
| description | Purpose. Pancreatitis can lead to systemic inflammatory response, but the relationship between lymphocyte changes and patients with pancreatitis remains unclear. In this study, we evaluated the feedback function of changes in peripheral lymphocyte subsets on the condition of patients with pancreatitis. Materials and Methods. 131 acute pancreatitis (AP) patients and 11 chronic pancreatitis (CP) patients constituted the patients’ group; 20 healthy individuals were enrolled as healthy controls (HC). Serum concentration of C-reactive protein (CRP), amylase, and lipase and the frequency and absolute number of many types of peripheral lymphocytes (including T, B, NK, CD16+/CD56+ T, CD4+ T, CD8+ T, CD4+CD8+ T, and CD4−CD8− T cells) were detected on admission and the seventh day of standard treatment. Besides, the length of hospital stay was recorded. Results. The absolute number of all lymphocytes we studied decreased in patients with CP and in patients with almost all types of AP. The frequency change of lymphocytes varies among the different types of AP. During disease onset, B cell frequency correlated positively with CRP concentration and NK cell frequency correlated positively with amylase and lipase concentration. B cell frequency and CD4+ T cell absolute number were recovering towards normal after short-term treatment. The frequency of B cells and NK cells correlated positively with the length of hospital stay. Conclusions. B cells and NK cells closely correlate with patients’ condition and may help to diagnose AP more accurately and reflect treatment effect of AP in time, affecting the recovery speed of patients with M-AP, which may help physicians to better understand the pathophysiology of pancreatitis. |
| format | Article |
| id | doaj-art-4382d43a20cc426bb2d0df1fd371707d |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-4382d43a20cc426bb2d0df1fd371707d2025-02-03T06:13:21ZengWileyGastroenterology Research and Practice1687-61211687-630X2019-01-01201910.1155/2019/75684107568410B and NK Cells Closely Correlate with the Condition of Patients with Acute PancreatitisXin Wei0Weifeng Yao1Huiping Li2Jingjing Qian3Yaosheng Xie4Zhuo Zhang5Hong Lu6Liang Shi7Xiangyang Lin8Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaPurpose. Pancreatitis can lead to systemic inflammatory response, but the relationship between lymphocyte changes and patients with pancreatitis remains unclear. In this study, we evaluated the feedback function of changes in peripheral lymphocyte subsets on the condition of patients with pancreatitis. Materials and Methods. 131 acute pancreatitis (AP) patients and 11 chronic pancreatitis (CP) patients constituted the patients’ group; 20 healthy individuals were enrolled as healthy controls (HC). Serum concentration of C-reactive protein (CRP), amylase, and lipase and the frequency and absolute number of many types of peripheral lymphocytes (including T, B, NK, CD16+/CD56+ T, CD4+ T, CD8+ T, CD4+CD8+ T, and CD4−CD8− T cells) were detected on admission and the seventh day of standard treatment. Besides, the length of hospital stay was recorded. Results. The absolute number of all lymphocytes we studied decreased in patients with CP and in patients with almost all types of AP. The frequency change of lymphocytes varies among the different types of AP. During disease onset, B cell frequency correlated positively with CRP concentration and NK cell frequency correlated positively with amylase and lipase concentration. B cell frequency and CD4+ T cell absolute number were recovering towards normal after short-term treatment. The frequency of B cells and NK cells correlated positively with the length of hospital stay. Conclusions. B cells and NK cells closely correlate with patients’ condition and may help to diagnose AP more accurately and reflect treatment effect of AP in time, affecting the recovery speed of patients with M-AP, which may help physicians to better understand the pathophysiology of pancreatitis.http://dx.doi.org/10.1155/2019/7568410 |
| spellingShingle | Xin Wei Weifeng Yao Huiping Li Jingjing Qian Yaosheng Xie Zhuo Zhang Hong Lu Liang Shi Xiangyang Lin B and NK Cells Closely Correlate with the Condition of Patients with Acute Pancreatitis Gastroenterology Research and Practice |
| title | B and NK Cells Closely Correlate with the Condition of Patients with Acute Pancreatitis |
| title_full | B and NK Cells Closely Correlate with the Condition of Patients with Acute Pancreatitis |
| title_fullStr | B and NK Cells Closely Correlate with the Condition of Patients with Acute Pancreatitis |
| title_full_unstemmed | B and NK Cells Closely Correlate with the Condition of Patients with Acute Pancreatitis |
| title_short | B and NK Cells Closely Correlate with the Condition of Patients with Acute Pancreatitis |
| title_sort | b and nk cells closely correlate with the condition of patients with acute pancreatitis |
| url | http://dx.doi.org/10.1155/2019/7568410 |
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