From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases
Abstract The transition from a comorbidity-based to a multimorbidity-focused to ultimately a network medicine approach in people with rheumatic diseases might mark a significant shift in how we understand and manage these complex conditions. Multimorbidity expands on the concept of comorbidity by en...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2024-11-01
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| Series: | Rheumatology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40744-024-00724-8 |
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| author | Winston Gilcrease Luca Manfredi Savino Sciascia Fulvio Ricceri |
| author_facet | Winston Gilcrease Luca Manfredi Savino Sciascia Fulvio Ricceri |
| author_sort | Winston Gilcrease |
| collection | DOAJ |
| description | Abstract The transition from a comorbidity-based to a multimorbidity-focused to ultimately a network medicine approach in people with rheumatic diseases might mark a significant shift in how we understand and manage these complex conditions. Multimorbidity expands on the concept of comorbidity by encompassing the presence of multiple diseases, which results in further individual and societal impacts. This approach, while valuable, often leads to fragmented care focused on individual diseases rather than the patient as a whole. Network medicine, on the other hand, offers a more integrated perspective. It is an emerging concept that leverages the understanding of biologic networks and their interactions within the human body to gain insights into disease mechanisms. In the context of rheumatic diseases, network medicine involves examining how different diseases interconnect and influence each other through shared pathways, genetic factors, and molecular mechanisms. This paradigm shift allows for a more holistic understanding in how we manage rheumatic diseases. For instance, rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus are not just a collection of symptoms affecting various organs but are also interconnected through underlying systemic inflammatory processes, immune system dysregulation, and genetic predispositions. |
| format | Article |
| id | doaj-art-437cd1eb61ec458c8563594411b9c0d6 |
| institution | Kabale University |
| issn | 2198-6576 2198-6584 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Rheumatology and Therapy |
| spelling | doaj-art-437cd1eb61ec458c8563594411b9c0d62025-01-26T12:52:07ZengAdis, Springer HealthcareRheumatology and Therapy2198-65762198-65842024-11-0112112410.1007/s40744-024-00724-8From Multimorbidity to Network Medicine in Patients with Rheumatic DiseasesWinston Gilcrease0Luca Manfredi1Savino Sciascia2Fulvio Ricceri3Department of Clinical and Biological Sciences, Centre for Biostatistics, Epidemiology, and Public Health, University of TurinDepartment of Clinical and Biological Sciences, Centre for Biostatistics, Epidemiology, and Public Health, University of TurinUniversity Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERK-Net, ERN-Reconnect and RITA-ERN Member) With Nephrology and Dialysis Unit and Center of Immuno-Rheumatology and Rare Diseases (CMID), Coordinating Center of the Interregional Network for Rare Diseases of Piedmont and Aosta Valley, ASL Città Di Torino and Department of Clinical and Biological Sciences, University of TurinDepartment of Clinical and Biological Sciences, Centre for Biostatistics, Epidemiology, and Public Health, University of TurinAbstract The transition from a comorbidity-based to a multimorbidity-focused to ultimately a network medicine approach in people with rheumatic diseases might mark a significant shift in how we understand and manage these complex conditions. Multimorbidity expands on the concept of comorbidity by encompassing the presence of multiple diseases, which results in further individual and societal impacts. This approach, while valuable, often leads to fragmented care focused on individual diseases rather than the patient as a whole. Network medicine, on the other hand, offers a more integrated perspective. It is an emerging concept that leverages the understanding of biologic networks and their interactions within the human body to gain insights into disease mechanisms. In the context of rheumatic diseases, network medicine involves examining how different diseases interconnect and influence each other through shared pathways, genetic factors, and molecular mechanisms. This paradigm shift allows for a more holistic understanding in how we manage rheumatic diseases. For instance, rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus are not just a collection of symptoms affecting various organs but are also interconnected through underlying systemic inflammatory processes, immune system dysregulation, and genetic predispositions.https://doi.org/10.1007/s40744-024-00724-8MultimorbidityNetwork medicineRheumatic DiseasesLupus erythematosusRheumatoid arthritis |
| spellingShingle | Winston Gilcrease Luca Manfredi Savino Sciascia Fulvio Ricceri From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases Rheumatology and Therapy Multimorbidity Network medicine Rheumatic Diseases Lupus erythematosus Rheumatoid arthritis |
| title | From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases |
| title_full | From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases |
| title_fullStr | From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases |
| title_full_unstemmed | From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases |
| title_short | From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases |
| title_sort | from multimorbidity to network medicine in patients with rheumatic diseases |
| topic | Multimorbidity Network medicine Rheumatic Diseases Lupus erythematosus Rheumatoid arthritis |
| url | https://doi.org/10.1007/s40744-024-00724-8 |
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