Flow-Mediated Dilatation in the Assessment of Coronary Heart Disease: A Meta-Analysis
Endothelial dysfunction may contribute to the increased morbidity and mortality associated with coronary heart disease (CHD). Flow-mediated dilatation (FMD) is the most popular noninvasive method for vascular endothelial function evaluation. This meta-analysis aimed to investigate the association be...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/7967324 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549709568278528 |
|---|---|
| author | Xiaoyong Xiao Xiang Li Xiaohua Xiao Jingjing Wang Dehong Liu Zhe Deng |
| author_facet | Xiaoyong Xiao Xiang Li Xiaohua Xiao Jingjing Wang Dehong Liu Zhe Deng |
| author_sort | Xiaoyong Xiao |
| collection | DOAJ |
| description | Endothelial dysfunction may contribute to the increased morbidity and mortality associated with coronary heart disease (CHD). Flow-mediated dilatation (FMD) is the most popular noninvasive method for vascular endothelial function evaluation. This meta-analysis aimed to investigate the association between FMD and CHD. We searched the publications listed in the PubMed, Web of Science, Scopus, and Embase databases. Stata 14 software was used to analyze the data. Standardized mean difference (SMD) was used to calculate FMD levels, and the effect sizes were expressed with a 95% confidence interval (CI). I2 statistics were used to evaluate statistical heterogeneity. In this meta-analysis, 9 studies enrolled a total number of 943 participants, including 534 (56.63%) patients with CHD and 409 controls (43.37%). We found that patients with CHD showed a significantly lower FMD than the controls (SMD −0.706%; 95% CI: −0.985, −0.427; P=0.001) with high heterogeneity. In addition, funnel plot analysis suggested asymmetry that could be evidence of publication bias. But sensitivity analyses show that there were no influential studies. This meta-analysis provides evidence that patients with CHD show a significantly lower FMD than controls and highlights the literature on FMD as a hallmark in CHD diseases. |
| format | Article |
| id | doaj-art-437aeb5c500942988aa43d4ed4b0b46a |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-437aeb5c500942988aa43d4ed4b0b46a2025-02-03T06:08:43ZengWileyCardiology Research and Practice2090-05972022-01-01202210.1155/2022/7967324Flow-Mediated Dilatation in the Assessment of Coronary Heart Disease: A Meta-AnalysisXiaoyong Xiao0Xiang Li1Xiaohua Xiao2Jingjing Wang3Dehong Liu4Zhe Deng5Department of EmergencyDepartment of UltrasoundDepartment of Geriatric MedicineDepartment of EmergencyDepartment of EmergencyDepartment of EmergencyEndothelial dysfunction may contribute to the increased morbidity and mortality associated with coronary heart disease (CHD). Flow-mediated dilatation (FMD) is the most popular noninvasive method for vascular endothelial function evaluation. This meta-analysis aimed to investigate the association between FMD and CHD. We searched the publications listed in the PubMed, Web of Science, Scopus, and Embase databases. Stata 14 software was used to analyze the data. Standardized mean difference (SMD) was used to calculate FMD levels, and the effect sizes were expressed with a 95% confidence interval (CI). I2 statistics were used to evaluate statistical heterogeneity. In this meta-analysis, 9 studies enrolled a total number of 943 participants, including 534 (56.63%) patients with CHD and 409 controls (43.37%). We found that patients with CHD showed a significantly lower FMD than the controls (SMD −0.706%; 95% CI: −0.985, −0.427; P=0.001) with high heterogeneity. In addition, funnel plot analysis suggested asymmetry that could be evidence of publication bias. But sensitivity analyses show that there were no influential studies. This meta-analysis provides evidence that patients with CHD show a significantly lower FMD than controls and highlights the literature on FMD as a hallmark in CHD diseases.http://dx.doi.org/10.1155/2022/7967324 |
| spellingShingle | Xiaoyong Xiao Xiang Li Xiaohua Xiao Jingjing Wang Dehong Liu Zhe Deng Flow-Mediated Dilatation in the Assessment of Coronary Heart Disease: A Meta-Analysis Cardiology Research and Practice |
| title | Flow-Mediated Dilatation in the Assessment of Coronary Heart Disease: A Meta-Analysis |
| title_full | Flow-Mediated Dilatation in the Assessment of Coronary Heart Disease: A Meta-Analysis |
| title_fullStr | Flow-Mediated Dilatation in the Assessment of Coronary Heart Disease: A Meta-Analysis |
| title_full_unstemmed | Flow-Mediated Dilatation in the Assessment of Coronary Heart Disease: A Meta-Analysis |
| title_short | Flow-Mediated Dilatation in the Assessment of Coronary Heart Disease: A Meta-Analysis |
| title_sort | flow mediated dilatation in the assessment of coronary heart disease a meta analysis |
| url | http://dx.doi.org/10.1155/2022/7967324 |
| work_keys_str_mv | AT xiaoyongxiao flowmediateddilatationintheassessmentofcoronaryheartdiseaseametaanalysis AT xiangli flowmediateddilatationintheassessmentofcoronaryheartdiseaseametaanalysis AT xiaohuaxiao flowmediateddilatationintheassessmentofcoronaryheartdiseaseametaanalysis AT jingjingwang flowmediateddilatationintheassessmentofcoronaryheartdiseaseametaanalysis AT dehongliu flowmediateddilatationintheassessmentofcoronaryheartdiseaseametaanalysis AT zhedeng flowmediateddilatationintheassessmentofcoronaryheartdiseaseametaanalysis |