Polycystic Ovarian Condition May Be a Risk Factor for Ovarian Tumor Development in the Laying Hen Model of Spontaneous Ovarian Cancer
Chronic inflammation and long-standing oxidative stress are potential predisposing factors for developing malignancies, including ovarian cancer (OVCA). Information on the association of ovarian chronic abnormal conditions, including polycystic ovarian syndrome (PCOS), with the development of OVCA i...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/2590910 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556329339715584 |
|---|---|
| author | Hyun Ju Lee Janice M. Bahr Pincas Bitterman Sanjib Basu Sameer Sharma Jacques S. Abramowicz Animesh Barua |
| author_facet | Hyun Ju Lee Janice M. Bahr Pincas Bitterman Sanjib Basu Sameer Sharma Jacques S. Abramowicz Animesh Barua |
| author_sort | Hyun Ju Lee |
| collection | DOAJ |
| description | Chronic inflammation and long-standing oxidative stress are potential predisposing factors for developing malignancies, including ovarian cancer (OVCA). Information on the association of ovarian chronic abnormal conditions, including polycystic ovarian syndrome (PCOS), with the development of OVCA is unknown. The goal of this study was to examine if polycystic ovarian conditions are associated with OVCA development. In the exploratory study, 3–4-year-old laying hens were randomly selected and examined for the presence of polycystic ovaries with cancer (PCOC). In the prospective study, hens were monitored by ultrasound scanning to detect the incidence of a polycystic ovaries and subsequent development of OVCA. Tissues from normal ovaries and PCOC were examined for macrophage infiltration, expression of interleukin-16, and superoxide dismutase 2. The exploratory study detected spontaneous PCOC at early and late stages in hens. PCOC in hens were accompanied with influx of macrophages (17.33 ± 2.26 in PCOC at the early stage and 24.24 ± 2.5 in PCOC at the late stage in 20 mm2 areas of tissue as compared with 6.77 ± 1.58 in normal hens). Expression of interleukin-16 was more than 2.5-fold higher and superoxide dismutase 2 was approximately 3-fold higher in PCOC hens than normal hens. The prospective study showed the development of OVCA in some hens with polycystic ovarian condition (PCO). PCOC development in hens was associated with chronic inflammation in the ovary. Laying hens may represent a potential model for the study of spontaneous PCOS and its long-term risk of PCOC development. |
| format | Article |
| id | doaj-art-43710393d86e454998424baf48a5974c |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-43710393d86e454998424baf48a5974c2025-02-03T05:45:38ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/25909102590910Polycystic Ovarian Condition May Be a Risk Factor for Ovarian Tumor Development in the Laying Hen Model of Spontaneous Ovarian CancerHyun Ju Lee0Janice M. Bahr1Pincas Bitterman2Sanjib Basu3Sameer Sharma4Jacques S. Abramowicz5Animesh Barua6College of Pharmacy, University of Illinois at Chicago, IL, USADepartment of Animal Sciences, University of Illinois at Urbana-Champaign, IL, USADepartment of Pathology, Rush University Medical Center, Chicago, IL, USADepartment of Preventive Medicine, Rush University Medical Center, Chicago, IL, USADepartment of Obstetrics and Gynecology, Rush University Medical Center, Chicago, IL, USADepartment of Obstetrics and Gynecology, University of Chicago, IL, USADepartment of Pathology, Rush University Medical Center, Chicago, IL, USAChronic inflammation and long-standing oxidative stress are potential predisposing factors for developing malignancies, including ovarian cancer (OVCA). Information on the association of ovarian chronic abnormal conditions, including polycystic ovarian syndrome (PCOS), with the development of OVCA is unknown. The goal of this study was to examine if polycystic ovarian conditions are associated with OVCA development. In the exploratory study, 3–4-year-old laying hens were randomly selected and examined for the presence of polycystic ovaries with cancer (PCOC). In the prospective study, hens were monitored by ultrasound scanning to detect the incidence of a polycystic ovaries and subsequent development of OVCA. Tissues from normal ovaries and PCOC were examined for macrophage infiltration, expression of interleukin-16, and superoxide dismutase 2. The exploratory study detected spontaneous PCOC at early and late stages in hens. PCOC in hens were accompanied with influx of macrophages (17.33 ± 2.26 in PCOC at the early stage and 24.24 ± 2.5 in PCOC at the late stage in 20 mm2 areas of tissue as compared with 6.77 ± 1.58 in normal hens). Expression of interleukin-16 was more than 2.5-fold higher and superoxide dismutase 2 was approximately 3-fold higher in PCOC hens than normal hens. The prospective study showed the development of OVCA in some hens with polycystic ovarian condition (PCO). PCOC development in hens was associated with chronic inflammation in the ovary. Laying hens may represent a potential model for the study of spontaneous PCOS and its long-term risk of PCOC development.http://dx.doi.org/10.1155/2018/2590910 |
| spellingShingle | Hyun Ju Lee Janice M. Bahr Pincas Bitterman Sanjib Basu Sameer Sharma Jacques S. Abramowicz Animesh Barua Polycystic Ovarian Condition May Be a Risk Factor for Ovarian Tumor Development in the Laying Hen Model of Spontaneous Ovarian Cancer Journal of Immunology Research |
| title | Polycystic Ovarian Condition May Be a Risk Factor for Ovarian Tumor Development in the Laying Hen Model of Spontaneous Ovarian Cancer |
| title_full | Polycystic Ovarian Condition May Be a Risk Factor for Ovarian Tumor Development in the Laying Hen Model of Spontaneous Ovarian Cancer |
| title_fullStr | Polycystic Ovarian Condition May Be a Risk Factor for Ovarian Tumor Development in the Laying Hen Model of Spontaneous Ovarian Cancer |
| title_full_unstemmed | Polycystic Ovarian Condition May Be a Risk Factor for Ovarian Tumor Development in the Laying Hen Model of Spontaneous Ovarian Cancer |
| title_short | Polycystic Ovarian Condition May Be a Risk Factor for Ovarian Tumor Development in the Laying Hen Model of Spontaneous Ovarian Cancer |
| title_sort | polycystic ovarian condition may be a risk factor for ovarian tumor development in the laying hen model of spontaneous ovarian cancer |
| url | http://dx.doi.org/10.1155/2018/2590910 |
| work_keys_str_mv | AT hyunjulee polycysticovarianconditionmaybeariskfactorforovariantumordevelopmentinthelayinghenmodelofspontaneousovariancancer AT janicembahr polycysticovarianconditionmaybeariskfactorforovariantumordevelopmentinthelayinghenmodelofspontaneousovariancancer AT pincasbitterman polycysticovarianconditionmaybeariskfactorforovariantumordevelopmentinthelayinghenmodelofspontaneousovariancancer AT sanjibbasu polycysticovarianconditionmaybeariskfactorforovariantumordevelopmentinthelayinghenmodelofspontaneousovariancancer AT sameersharma polycysticovarianconditionmaybeariskfactorforovariantumordevelopmentinthelayinghenmodelofspontaneousovariancancer AT jacquessabramowicz polycysticovarianconditionmaybeariskfactorforovariantumordevelopmentinthelayinghenmodelofspontaneousovariancancer AT animeshbarua polycysticovarianconditionmaybeariskfactorforovariantumordevelopmentinthelayinghenmodelofspontaneousovariancancer |