The influence of H. pylori infection in HER2-positive gastric cancer cell lines: insights from Wnt/β-catenin pathway

The influence of H. pylori infection in HER2-positive gastric cancer cell lines: insights from Wnt/β-catenin pathway

IntroductionThe impact of H. pylori infection on the efficacy of trastuzumab in HER2-positive gastric cancer (GC) remains poorly understood, despite growing evidence that tumor microenvironment and host-pathogen interactions influence therapeutic outcomes. This study aimed to investigate how H. pylo...

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Main Authors: Valli De Re, Mariateresa Casarotto, Giulia Brisotto, Stefania Zanussi, Mariangela De Zorzi, Ombretta Repetto, Elena Muraro, Paola Spessotto, Paolo Baldo, Vito Racanelli, Marco Vincenzo Lenti, Marino Venerito, Matteo Fassan, Agostino Steffan, Stefano Realdon, Renato Cannizzaro
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
Helicobacter pylori
trastuzumab
HER2
gastric cancer
Wnt
PD-L1/PD-L2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1550651/full
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