Paraneoplastic anti-Yo antibody mediated subacute cerebellar degeneration. Case series and literature review
Paraneoplastic neurologic syndromes are a subgroup of diseases due to indirect cytotoxic effects of the immune system on specific brain structures rather than the mass effect itself. Paraneoplastic anti-Yo antibody mediated subacute cerebellar degeneration is characterised by an insidious onset, a...
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| Format: | Article |
| Language: | English |
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Vilnius University Press
2020-03-01
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| Series: | Neurologijos seminarai |
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| Online Access: | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27763 |
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| _version_ | 1832593061209702400 |
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| author | M. Vaišvilas R. Mameniškienė A. Barkauskienė |
| author_facet | M. Vaišvilas R. Mameniškienė A. Barkauskienė |
| author_sort | M. Vaišvilas |
| collection | DOAJ |
| description |
Paraneoplastic neurologic syndromes are a subgroup of diseases due to indirect cytotoxic effects of the immune system on specific brain structures rather than the mass effect itself. Paraneoplastic anti-Yo antibody mediated subacute cerebellar degeneration is characterised by an insidious onset, a characteristic neurologic syndrome of cerebellar dysfunction, normal or near/normal brain imaging on MRI, and gynaecologic malignancies identified by thorough investigation in middle aged post-menopausal women. Despite various aggressive treatments available, the prognosis is often considered poor. We present two cases with classical findings consistent with paraneoplastic subacute cerebellar degeneration and give literature review.
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| format | Article |
| id | doaj-art-4367c7254b204d1aaa60584c40ccf2ec |
| institution | Kabale University |
| issn | 1392-3064 2424-5917 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Vilnius University Press |
| record_format | Article |
| series | Neurologijos seminarai |
| spelling | doaj-art-4367c7254b204d1aaa60584c40ccf2ec2025-01-20T18:22:48ZengVilnius University PressNeurologijos seminarai1392-30642424-59172020-03-01241(83)10.29014/ns.2020.08Paraneoplastic anti-Yo antibody mediated subacute cerebellar degeneration. Case series and literature reviewM. Vaišvilas 0R. Mameniškienė 1A. Barkauskienė 2Vilnius University, LithuaniaVilnius University, LithuaniaVilnius University, Lithuania Paraneoplastic neurologic syndromes are a subgroup of diseases due to indirect cytotoxic effects of the immune system on specific brain structures rather than the mass effect itself. Paraneoplastic anti-Yo antibody mediated subacute cerebellar degeneration is characterised by an insidious onset, a characteristic neurologic syndrome of cerebellar dysfunction, normal or near/normal brain imaging on MRI, and gynaecologic malignancies identified by thorough investigation in middle aged post-menopausal women. Despite various aggressive treatments available, the prognosis is often considered poor. We present two cases with classical findings consistent with paraneoplastic subacute cerebellar degeneration and give literature review. https://www.journals.vu.lt/neurologijos_seminarai/article/view/27763autoimmune encephalitisparaneoplastic neurologic syndromeantineuronal antibodiesparaneoplastic cerebellar degeneration |
| spellingShingle | M. Vaišvilas R. Mameniškienė A. Barkauskienė Paraneoplastic anti-Yo antibody mediated subacute cerebellar degeneration. Case series and literature review Neurologijos seminarai autoimmune encephalitis paraneoplastic neurologic syndrome antineuronal antibodies paraneoplastic cerebellar degeneration |
| title | Paraneoplastic anti-Yo antibody mediated subacute cerebellar degeneration. Case series and literature review |
| title_full | Paraneoplastic anti-Yo antibody mediated subacute cerebellar degeneration. Case series and literature review |
| title_fullStr | Paraneoplastic anti-Yo antibody mediated subacute cerebellar degeneration. Case series and literature review |
| title_full_unstemmed | Paraneoplastic anti-Yo antibody mediated subacute cerebellar degeneration. Case series and literature review |
| title_short | Paraneoplastic anti-Yo antibody mediated subacute cerebellar degeneration. Case series and literature review |
| title_sort | paraneoplastic anti yo antibody mediated subacute cerebellar degeneration case series and literature review |
| topic | autoimmune encephalitis paraneoplastic neurologic syndrome antineuronal antibodies paraneoplastic cerebellar degeneration |
| url | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27763 |
| work_keys_str_mv | AT mvaisvilas paraneoplasticantiyoantibodymediatedsubacutecerebellardegenerationcaseseriesandliteraturereview AT rmameniskiene paraneoplasticantiyoantibodymediatedsubacutecerebellardegenerationcaseseriesandliteraturereview AT abarkauskiene paraneoplasticantiyoantibodymediatedsubacutecerebellardegenerationcaseseriesandliteraturereview |