HMGB-1 as a Novel Predictor of Disease Severity and Prognosis in Patients with Hemorrhagic Fever with Renal Syndrome
Objective. To examine the predictive capacity of the high mobility group box protein-1 (HMGB-1) for disease severity and prognosis of hemorrhagic fever with renal syndrome (HFRS). Methods. One hundred and five HFRS patients and 28 controls were studied. The concentrations of HMGB-1 in the blood were...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/696248 |
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| author | Hong Du Jing Li Haitao Yu Jianqi Lian Ye Zhang Ying Zhang Xuefan Bai Pingzhong Wang |
| author_facet | Hong Du Jing Li Haitao Yu Jianqi Lian Ye Zhang Ying Zhang Xuefan Bai Pingzhong Wang |
| author_sort | Hong Du |
| collection | DOAJ |
| description | Objective. To examine the predictive capacity of the high mobility group box protein-1 (HMGB-1) for disease severity and prognosis of hemorrhagic fever with renal syndrome (HFRS). Methods. One hundred and five HFRS patients and 28 controls were studied. The concentrations of HMGB-1 in the blood were measured with a commercially available ELISA. The levels of white blood cells (WBC), platelets (PLT), hematocrit (HCT), albumin (ALB), blood urea nitrogen (BUN), serum creatinine (Scr), and uric acid (UA) were routinely tested in the same time frame. Results. The levels of HMGB-1 increased with the severity of the disease (P<0.001). HMGB-1 was positively correlated with WBC and BUN and negatively correlated with PLT, ALB, and UA (P<0.001). HMGB-1 showed statistical significance for predicting prognosis (AUC = 0.800, P<0.001). The sensitivity and specificity of HMGB-1, WBC, PLT, and ALB used in combination for predicting outcome were better than those of single analyses (AUC = 0.892, P<0.001). Conclusions. HMGB-1 can be considered a novel biomarker for severity and outcome in patients with HFRS. The use of HMGB-1, WBC, PLT, and ALB in combination to predict the outcome in patients with HFRS exhibited an acceptable level of diagnostic capability. |
| format | Article |
| id | doaj-art-435f7c1e060d421784a33bcda7d979db |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-435f7c1e060d421784a33bcda7d979db2025-02-03T06:08:47ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/696248696248HMGB-1 as a Novel Predictor of Disease Severity and Prognosis in Patients with Hemorrhagic Fever with Renal SyndromeHong Du0Jing Li1Haitao Yu2Jianqi Lian3Ye Zhang4Ying Zhang5Xuefan Bai6Pingzhong Wang7Center of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, ChinaCenter of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, ChinaCenter of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, ChinaCenter of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, ChinaCenter of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, ChinaCenter of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, ChinaCenter of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, ChinaCenter of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, ChinaObjective. To examine the predictive capacity of the high mobility group box protein-1 (HMGB-1) for disease severity and prognosis of hemorrhagic fever with renal syndrome (HFRS). Methods. One hundred and five HFRS patients and 28 controls were studied. The concentrations of HMGB-1 in the blood were measured with a commercially available ELISA. The levels of white blood cells (WBC), platelets (PLT), hematocrit (HCT), albumin (ALB), blood urea nitrogen (BUN), serum creatinine (Scr), and uric acid (UA) were routinely tested in the same time frame. Results. The levels of HMGB-1 increased with the severity of the disease (P<0.001). HMGB-1 was positively correlated with WBC and BUN and negatively correlated with PLT, ALB, and UA (P<0.001). HMGB-1 showed statistical significance for predicting prognosis (AUC = 0.800, P<0.001). The sensitivity and specificity of HMGB-1, WBC, PLT, and ALB used in combination for predicting outcome were better than those of single analyses (AUC = 0.892, P<0.001). Conclusions. HMGB-1 can be considered a novel biomarker for severity and outcome in patients with HFRS. The use of HMGB-1, WBC, PLT, and ALB in combination to predict the outcome in patients with HFRS exhibited an acceptable level of diagnostic capability.http://dx.doi.org/10.1155/2015/696248 |
| spellingShingle | Hong Du Jing Li Haitao Yu Jianqi Lian Ye Zhang Ying Zhang Xuefan Bai Pingzhong Wang HMGB-1 as a Novel Predictor of Disease Severity and Prognosis in Patients with Hemorrhagic Fever with Renal Syndrome Mediators of Inflammation |
| title | HMGB-1 as a Novel Predictor of Disease Severity and Prognosis in Patients with Hemorrhagic Fever with Renal Syndrome |
| title_full | HMGB-1 as a Novel Predictor of Disease Severity and Prognosis in Patients with Hemorrhagic Fever with Renal Syndrome |
| title_fullStr | HMGB-1 as a Novel Predictor of Disease Severity and Prognosis in Patients with Hemorrhagic Fever with Renal Syndrome |
| title_full_unstemmed | HMGB-1 as a Novel Predictor of Disease Severity and Prognosis in Patients with Hemorrhagic Fever with Renal Syndrome |
| title_short | HMGB-1 as a Novel Predictor of Disease Severity and Prognosis in Patients with Hemorrhagic Fever with Renal Syndrome |
| title_sort | hmgb 1 as a novel predictor of disease severity and prognosis in patients with hemorrhagic fever with renal syndrome |
| url | http://dx.doi.org/10.1155/2015/696248 |
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