Characteristics and Treatment Results of 5 Patients with Fibrous Dysplasia and Review of the Literature
Aim. Fibrous dysplasia is a rare bone disease caused by missense mutation leading to abnormal fibroblast and osteoblast proliferation and increased bone resorption. FD can present in monostotic or polyostotic forms. About 3% of FD could be in association with McCune-Albright syndrome (MAS). Because...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/670809 |
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| author | Nilufer Ozdemir Kutbay Banu Sarer Yurekli Emine Kartal Baykan Serap Baydur Sahin Fusun Saygili |
| author_facet | Nilufer Ozdemir Kutbay Banu Sarer Yurekli Emine Kartal Baykan Serap Baydur Sahin Fusun Saygili |
| author_sort | Nilufer Ozdemir Kutbay |
| collection | DOAJ |
| description | Aim. Fibrous dysplasia is a rare bone disease caused by missense mutation leading to abnormal fibroblast and osteoblast proliferation and increased bone resorption. FD can present in monostotic or polyostotic forms. About 3% of FD could be in association with McCune-Albright syndrome (MAS). Because FD is a rare disease, there is limited data in the literature about characteristics of disease and response to treatment. Methods. We present our five cases of FD with general properties and their responses to medical treatment. Results. Two of our patients had polyostotic and three had monostotic FD. One of the polyostotic patients had MAS. One of our patients had surgery for femur fractures, facial asymmetry, and findings of compression. Four patients were given pamidronate; one was given zoledronic acid as bisphosphonate treatment. Bone pain was relieved in all patients with medical treatment. Conclusion. There was a decrease in bone turnover markers to some degree with medical treatment but no radiological improvement was observed. |
| format | Article |
| id | doaj-art-435c99df01824b0fb226e0529c2ad92a |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-435c99df01824b0fb226e0529c2ad92a2025-02-03T01:24:20ZengWileyCase Reports in Endocrinology2090-65012090-651X2015-01-01201510.1155/2015/670809670809Characteristics and Treatment Results of 5 Patients with Fibrous Dysplasia and Review of the LiteratureNilufer Ozdemir Kutbay0Banu Sarer Yurekli1Emine Kartal Baykan2Serap Baydur Sahin3Fusun Saygili4Endocrinology Department, Ege University Faculty of Medicine, Izmir, TurkeyEndocrinology Department, Ege University Faculty of Medicine, Izmir, TurkeyEndocrinology Department, Ege University Faculty of Medicine, Izmir, TurkeyEndocrinology Department, Recep Tayyip Erdogan University Faculty of Medicine, Rize, TurkeyEndocrinology Department, Ege University Faculty of Medicine, Izmir, TurkeyAim. Fibrous dysplasia is a rare bone disease caused by missense mutation leading to abnormal fibroblast and osteoblast proliferation and increased bone resorption. FD can present in monostotic or polyostotic forms. About 3% of FD could be in association with McCune-Albright syndrome (MAS). Because FD is a rare disease, there is limited data in the literature about characteristics of disease and response to treatment. Methods. We present our five cases of FD with general properties and their responses to medical treatment. Results. Two of our patients had polyostotic and three had monostotic FD. One of the polyostotic patients had MAS. One of our patients had surgery for femur fractures, facial asymmetry, and findings of compression. Four patients were given pamidronate; one was given zoledronic acid as bisphosphonate treatment. Bone pain was relieved in all patients with medical treatment. Conclusion. There was a decrease in bone turnover markers to some degree with medical treatment but no radiological improvement was observed.http://dx.doi.org/10.1155/2015/670809 |
| spellingShingle | Nilufer Ozdemir Kutbay Banu Sarer Yurekli Emine Kartal Baykan Serap Baydur Sahin Fusun Saygili Characteristics and Treatment Results of 5 Patients with Fibrous Dysplasia and Review of the Literature Case Reports in Endocrinology |
| title | Characteristics and Treatment Results of 5 Patients with Fibrous Dysplasia and Review of the Literature |
| title_full | Characteristics and Treatment Results of 5 Patients with Fibrous Dysplasia and Review of the Literature |
| title_fullStr | Characteristics and Treatment Results of 5 Patients with Fibrous Dysplasia and Review of the Literature |
| title_full_unstemmed | Characteristics and Treatment Results of 5 Patients with Fibrous Dysplasia and Review of the Literature |
| title_short | Characteristics and Treatment Results of 5 Patients with Fibrous Dysplasia and Review of the Literature |
| title_sort | characteristics and treatment results of 5 patients with fibrous dysplasia and review of the literature |
| url | http://dx.doi.org/10.1155/2015/670809 |
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