The GPR120 agonist TUG‐891 promotes metabolic health by stimulating mitochondrial respiration in brown fat

The GPR120 agonist TUG‐891 promotes metabolic health by stimulating mitochondrial respiration in brown fat

Abstract Brown adipose tissue (BAT) activation stimulates energy expenditure in human adults, which makes it an attractive target to combat obesity and related disorders. Recent studies demonstrated a role for G protein‐coupled receptor 120 (GPR120) in BAT thermogenesis. Here, we investigated the th...

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Main Authors: Maaike Schilperoort, Andrea D van Dam, Geerte Hoeke, Irina G Shabalina, Anthony Okolo, Aylin C Hanyaloglu, Lea H Dib, Isabel M Mol, Natarin Caengprasath, Yi‐Wah Chan, Sami Damak, Anne Reifel Miller, Tamer Coskun, Bharat Shimpukade, Trond Ulven, Sander Kooijman, Patrick CN Rensen, Mark Christian
Format: Article
Language:English
Published: Springer Nature 2018-01-01
Series:EMBO Molecular Medicine
Subjects:
brown adipose tissue
Ca2+
GPR120
lipid metabolism
mitochondria
Online Access:https://doi.org/10.15252/emmm.201708047
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