Some Basic Aspects of HLA-G Biology
Human leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslatio...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/657625 |
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| _version_ | 1832547214528872448 |
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| author | Estibaliz Alegre Roberta Rizzo Daria Bortolotti Sara Fernandez-Landázuri Enrico Fainardi Alvaro González |
| author_facet | Estibaliz Alegre Roberta Rizzo Daria Bortolotti Sara Fernandez-Landázuri Enrico Fainardi Alvaro González |
| author_sort | Estibaliz Alegre |
| collection | DOAJ |
| description | Human leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslational modifications or even complex formations. In addition, HLA-G has been described included in exosomes. In this review we will focus on HLA-G biochemistry with special emphasis to the mechanisms that regulate its expression and how the protein modifications affect the quantification in biological fluids. |
| format | Article |
| id | doaj-art-43415e8e87ca4df190bffa5f2f6b8ada |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-43415e8e87ca4df190bffa5f2f6b8ada2025-02-03T06:45:28ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/657625657625Some Basic Aspects of HLA-G BiologyEstibaliz Alegre0Roberta Rizzo1Daria Bortolotti2Sara Fernandez-Landázuri3Enrico Fainardi4Alvaro González5Department of Biochemistry, University Clinic of Navarra, Pamplona, SpainDepartment of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, ItalyDepartment of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, ItalyDepartment of Biochemistry, University Clinic of Navarra, Pamplona, SpainNeuroradiology Unit, Sant’Anna Hospital, Ferrara, ItalyDepartment of Biochemistry, University Clinic of Navarra, Pamplona, SpainHuman leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslational modifications or even complex formations. In addition, HLA-G has been described included in exosomes. In this review we will focus on HLA-G biochemistry with special emphasis to the mechanisms that regulate its expression and how the protein modifications affect the quantification in biological fluids.http://dx.doi.org/10.1155/2014/657625 |
| spellingShingle | Estibaliz Alegre Roberta Rizzo Daria Bortolotti Sara Fernandez-Landázuri Enrico Fainardi Alvaro González Some Basic Aspects of HLA-G Biology Journal of Immunology Research |
| title | Some Basic Aspects of HLA-G Biology |
| title_full | Some Basic Aspects of HLA-G Biology |
| title_fullStr | Some Basic Aspects of HLA-G Biology |
| title_full_unstemmed | Some Basic Aspects of HLA-G Biology |
| title_short | Some Basic Aspects of HLA-G Biology |
| title_sort | some basic aspects of hla g biology |
| url | http://dx.doi.org/10.1155/2014/657625 |
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