Alterations of Interhemispheric Functional Connectivity and Degree Centrality in Cervical Dystonia: A Resting-State fMRI Study
Background. Cervical dystonia (CD) is a neurological movement disorder characterized by involuntary head and neck movements and postures. Reports on microstructural and functional abnormalities in multiple brain regions not limited to the basal ganglia have been increasing in patients with CD. Howev...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/7349894 |
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| author | Wenyan Jiang Yiwu Lei Jing Wei Lu Yang Shubao Wei Qiong Yin Shuguang Luo Wenbin Guo |
| author_facet | Wenyan Jiang Yiwu Lei Jing Wei Lu Yang Shubao Wei Qiong Yin Shuguang Luo Wenbin Guo |
| author_sort | Wenyan Jiang |
| collection | DOAJ |
| description | Background. Cervical dystonia (CD) is a neurological movement disorder characterized by involuntary head and neck movements and postures. Reports on microstructural and functional abnormalities in multiple brain regions not limited to the basal ganglia have been increasing in patients with CD. However, the neural bases of CD are unclear. This study is aimed at identifying cerebral functional abnormalities in CD by using resting-state functional magnetic resonance imaging (rs-fMRI). Methods. Using rs-fMRI data, voxel-mirrored homotopic connectivity (VMHC) and degree centrality were used to compare the alterations of the rs-functional connectivity (FC) between 19 patients with CD and 21 healthy controls. Regions showing abnormal FCs from two measurements were the regions of interest for correlation analyses. Results. Compared with healthy controls, patients with CD exhibited significantly decreased VMHC in the supplementary motor area (SMA), precuneus (PCu)/postcentral gyrus, and superior medial prefrontal cortex (MPFC). Significantly increased degree centrality in the right PCu and decreased degree centrality in the right lentiform nucleus and left ventral MPFC were observed in the patient group compared with the control group. Further correlation analyses showed that the VMHC values in the SMA were negatively correlated with dystonia severity. Conclusion. Local abnormalities and interhemispheric interaction deficits in the sensorimotor network (SMA, postcentral gyrus, and PCu), default mode network (MPFC and PCu), and basal ganglia may be the key characteristics in the pathogenesis mechanism of CD. |
| format | Article |
| id | doaj-art-4339150414da4fa5b73cf5ab5ba82800 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-4339150414da4fa5b73cf5ab5ba828002025-02-03T01:11:13ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/73498947349894Alterations of Interhemispheric Functional Connectivity and Degree Centrality in Cervical Dystonia: A Resting-State fMRI StudyWenyan Jiang0Yiwu Lei1Jing Wei2Lu Yang3Shubao Wei4Qiong Yin5Shuguang Luo6Wenbin Guo7Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, ChinaDepartment of Radiology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, ChinaDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, ChinaDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, ChinaDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, ChinaDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, ChinaDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, ChinaDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, ChinaBackground. Cervical dystonia (CD) is a neurological movement disorder characterized by involuntary head and neck movements and postures. Reports on microstructural and functional abnormalities in multiple brain regions not limited to the basal ganglia have been increasing in patients with CD. However, the neural bases of CD are unclear. This study is aimed at identifying cerebral functional abnormalities in CD by using resting-state functional magnetic resonance imaging (rs-fMRI). Methods. Using rs-fMRI data, voxel-mirrored homotopic connectivity (VMHC) and degree centrality were used to compare the alterations of the rs-functional connectivity (FC) between 19 patients with CD and 21 healthy controls. Regions showing abnormal FCs from two measurements were the regions of interest for correlation analyses. Results. Compared with healthy controls, patients with CD exhibited significantly decreased VMHC in the supplementary motor area (SMA), precuneus (PCu)/postcentral gyrus, and superior medial prefrontal cortex (MPFC). Significantly increased degree centrality in the right PCu and decreased degree centrality in the right lentiform nucleus and left ventral MPFC were observed in the patient group compared with the control group. Further correlation analyses showed that the VMHC values in the SMA were negatively correlated with dystonia severity. Conclusion. Local abnormalities and interhemispheric interaction deficits in the sensorimotor network (SMA, postcentral gyrus, and PCu), default mode network (MPFC and PCu), and basal ganglia may be the key characteristics in the pathogenesis mechanism of CD.http://dx.doi.org/10.1155/2019/7349894 |
| spellingShingle | Wenyan Jiang Yiwu Lei Jing Wei Lu Yang Shubao Wei Qiong Yin Shuguang Luo Wenbin Guo Alterations of Interhemispheric Functional Connectivity and Degree Centrality in Cervical Dystonia: A Resting-State fMRI Study Neural Plasticity |
| title | Alterations of Interhemispheric Functional Connectivity and Degree Centrality in Cervical Dystonia: A Resting-State fMRI Study |
| title_full | Alterations of Interhemispheric Functional Connectivity and Degree Centrality in Cervical Dystonia: A Resting-State fMRI Study |
| title_fullStr | Alterations of Interhemispheric Functional Connectivity and Degree Centrality in Cervical Dystonia: A Resting-State fMRI Study |
| title_full_unstemmed | Alterations of Interhemispheric Functional Connectivity and Degree Centrality in Cervical Dystonia: A Resting-State fMRI Study |
| title_short | Alterations of Interhemispheric Functional Connectivity and Degree Centrality in Cervical Dystonia: A Resting-State fMRI Study |
| title_sort | alterations of interhemispheric functional connectivity and degree centrality in cervical dystonia a resting state fmri study |
| url | http://dx.doi.org/10.1155/2019/7349894 |
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