Formation of the Ventricles
The formation of the ventricles of the heart involves numerous carefully regulated temporal events, including the initial specification and deployment of ventricular progenitors, subsequent growth and maturation of the ventricles through “ballooning” of chamber myocardium, the emergence of trabecula...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2006.316 |
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| _version_ | 1832551457957609472 |
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| author | Catherine A. Risebro Paul R. Riley |
| author_facet | Catherine A. Risebro Paul R. Riley |
| author_sort | Catherine A. Risebro |
| collection | DOAJ |
| description | The formation of the ventricles of the heart involves numerous carefully regulated temporal events, including the initial specification and deployment of ventricular progenitors, subsequent growth and maturation of the ventricles through “ballooning” of chamber myocardium, the emergence of trabeculations, the generation of the compact myocardium, and the formation of the interventricular septum. Several genes have been identified through studies on mouse knockout and transgenic models, which have contributed to our understanding of the molecular events governing these developmental processes. Interpretation of these studies highlights the fact that even the smallest perturbation at any stage of ventricular development may lead to cardiac malformations that result in either early embryonic mortality or a manifestation of congenital heart disease. |
| format | Article |
| id | doaj-art-432aa0302f7c4568abd9dc5c36e38fdd |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-432aa0302f7c4568abd9dc5c36e38fdd2025-02-03T06:01:23ZengWileyThe Scientific World Journal1537-744X2006-01-0161862188010.1100/tsw.2006.316Formation of the VentriclesCatherine A. Risebro0Paul R. Riley1UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UKUCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UKThe formation of the ventricles of the heart involves numerous carefully regulated temporal events, including the initial specification and deployment of ventricular progenitors, subsequent growth and maturation of the ventricles through “ballooning” of chamber myocardium, the emergence of trabeculations, the generation of the compact myocardium, and the formation of the interventricular septum. Several genes have been identified through studies on mouse knockout and transgenic models, which have contributed to our understanding of the molecular events governing these developmental processes. Interpretation of these studies highlights the fact that even the smallest perturbation at any stage of ventricular development may lead to cardiac malformations that result in either early embryonic mortality or a manifestation of congenital heart disease.http://dx.doi.org/10.1100/tsw.2006.316 |
| spellingShingle | Catherine A. Risebro Paul R. Riley Formation of the Ventricles The Scientific World Journal |
| title | Formation of the Ventricles |
| title_full | Formation of the Ventricles |
| title_fullStr | Formation of the Ventricles |
| title_full_unstemmed | Formation of the Ventricles |
| title_short | Formation of the Ventricles |
| title_sort | formation of the ventricles |
| url | http://dx.doi.org/10.1100/tsw.2006.316 |
| work_keys_str_mv | AT catherinearisebro formationoftheventricles AT paulrriley formationoftheventricles |