Emerging Roles of BAI Adhesion-GPCRs in Synapse Development and Plasticity
Synapses mediate communication between neurons and enable the brain to change in response to experience, which is essential for learning and memory. The sites of most excitatory synapses in the brain, dendritic spines, undergo rapid remodeling that is important for neural circuit formation and synap...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/8301737 |
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| author | Joseph G. Duman Yen-Kuei Tu Kimberley F. Tolias |
| author_facet | Joseph G. Duman Yen-Kuei Tu Kimberley F. Tolias |
| author_sort | Joseph G. Duman |
| collection | DOAJ |
| description | Synapses mediate communication between neurons and enable the brain to change in response to experience, which is essential for learning and memory. The sites of most excitatory synapses in the brain, dendritic spines, undergo rapid remodeling that is important for neural circuit formation and synaptic plasticity. Abnormalities in synapse and spine formation and plasticity are associated with a broad range of brain disorders, including intellectual disabilities, autism spectrum disorders (ASD), and schizophrenia. Thus, elucidating the mechanisms that regulate these neuronal processes is critical for understanding brain function and disease. The brain-specific angiogenesis inhibitor (BAI) subfamily of adhesion G-protein-coupled receptors (adhesion-GPCRs) has recently emerged as central regulators of synapse development and plasticity. In this review, we will summarize the current knowledge regarding the roles of BAIs at synapses, highlighting their regulation, downstream signaling, and physiological functions, while noting the roles of other adhesion-GPCRs at synapses. We will also discuss the relevance of BAIs in various neurological and psychiatric disorders and consider their potential importance as pharmacological targets in the treatment of these diseases. |
| format | Article |
| id | doaj-art-43287677866341b49e3ed6b58179e7d0 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-43287677866341b49e3ed6b58179e7d02025-02-03T01:32:30ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/83017378301737Emerging Roles of BAI Adhesion-GPCRs in Synapse Development and PlasticityJoseph G. Duman0Yen-Kuei Tu1Kimberley F. Tolias2Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USADepartment of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USADepartment of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USASynapses mediate communication between neurons and enable the brain to change in response to experience, which is essential for learning and memory. The sites of most excitatory synapses in the brain, dendritic spines, undergo rapid remodeling that is important for neural circuit formation and synaptic plasticity. Abnormalities in synapse and spine formation and plasticity are associated with a broad range of brain disorders, including intellectual disabilities, autism spectrum disorders (ASD), and schizophrenia. Thus, elucidating the mechanisms that regulate these neuronal processes is critical for understanding brain function and disease. The brain-specific angiogenesis inhibitor (BAI) subfamily of adhesion G-protein-coupled receptors (adhesion-GPCRs) has recently emerged as central regulators of synapse development and plasticity. In this review, we will summarize the current knowledge regarding the roles of BAIs at synapses, highlighting their regulation, downstream signaling, and physiological functions, while noting the roles of other adhesion-GPCRs at synapses. We will also discuss the relevance of BAIs in various neurological and psychiatric disorders and consider their potential importance as pharmacological targets in the treatment of these diseases.http://dx.doi.org/10.1155/2016/8301737 |
| spellingShingle | Joseph G. Duman Yen-Kuei Tu Kimberley F. Tolias Emerging Roles of BAI Adhesion-GPCRs in Synapse Development and Plasticity Neural Plasticity |
| title | Emerging Roles of BAI Adhesion-GPCRs in Synapse Development and Plasticity |
| title_full | Emerging Roles of BAI Adhesion-GPCRs in Synapse Development and Plasticity |
| title_fullStr | Emerging Roles of BAI Adhesion-GPCRs in Synapse Development and Plasticity |
| title_full_unstemmed | Emerging Roles of BAI Adhesion-GPCRs in Synapse Development and Plasticity |
| title_short | Emerging Roles of BAI Adhesion-GPCRs in Synapse Development and Plasticity |
| title_sort | emerging roles of bai adhesion gpcrs in synapse development and plasticity |
| url | http://dx.doi.org/10.1155/2016/8301737 |
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