Secukinumab Treatment in Patients With Hidradenitis Suppurativa in Real-World Clinical Settings: A Multicenter Study
Introduction: Treatment of hidradenitis suppurativa (HS) remains a challenge in clinical practice for dermatologists. Although the efficacy and safety of secukinumab (SEC) in the treatment of HS has been demonstrated in phase III studies, real-world data is limited. Objectives: We conducted a ret...
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Mattioli1885
2025-01-01
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| Series: | Dermatology Practical & Conceptual |
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| Online Access: | https://dpcj.org/index.php/dpc/article/view/4915 |
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| author | Ece Erbağcı Özge Sevil Karstarlı Bakay Fatma Aslı Hapa |
| author_facet | Ece Erbağcı Özge Sevil Karstarlı Bakay Fatma Aslı Hapa |
| author_sort | Ece Erbağcı |
| collection | DOAJ |
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Introduction: Treatment of hidradenitis suppurativa (HS) remains a challenge in clinical practice for dermatologists. Although the efficacy and safety of secukinumab (SEC) in the treatment of HS has been demonstrated in phase III studies, real-world data is limited.
Objectives: We conducted a retrospective multicenter study to evaluate the efficacy and safety of SEC treatment in HS patients in real-world settings.
Methods: Adult patients who were diagnosed with HS and used SEC for at least 3 months were included in the study.
Results: A total of 31 patients were included in the study; 14 of them (45.2%) were female. The mean age was 39.32 ± 10.26 years, and the mean disease duration was 11.77 ± 7.99 years. Nine (29%) patients were biologic-naive and 10 (32.3%) were adalimumab-naive. Disease severity was Hurley I in 7 patients (22.6%), Hurley II in 9 patients (29%), and Hurley III in 15 patients (48.4%). The Hidradenitis Suppurativa Clinical Response (HiSCR) was achieved in 20 patients (64.5%) in the third month of treatment. SEC treatment was discontinued due to primary ineffectiveness in 9 (29%) patients, secondary ineffectiveness in 1 (3.2%) patient, adverse effects in 1 (3.2%) patient, and loss of follow-up in 1 (3.2%) patient. Paradoxical pyoderma gangrenosum was observed as an adverse effect in 1 patient that resolved after discontinuing SEC and starting infliximab.
Conclusion: SEC appears to be an effective and safe treatment option for HS, especially when used in the early and mild stages of the disease and in biologic-naive patients.
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| format | Article |
| id | doaj-art-432299e343434015987f04180dc63264 |
| institution | Kabale University |
| issn | 2160-9381 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Dermatology Practical & Conceptual |
| spelling | doaj-art-432299e343434015987f04180dc632642025-02-04T15:41:28ZengMattioli1885Dermatology Practical & Conceptual2160-93812025-01-0115110.5826/dpc.1501a4915Secukinumab Treatment in Patients With Hidradenitis Suppurativa in Real-World Clinical Settings: A Multicenter StudyEce Erbağcı0Özge Sevil Karstarlı Bakay1Fatma Aslı Hapa2Uşak University Training and Research Hospital, Department of Dermatology and Venereology, UşakPamukkale University Faculty of Medicine, Department of Dermatology and Venereology, DenizliIzmir Democracy University Buca Seyfi Demirsoy Training and Research Hospital, Department of Dermatology and Venereology, Izmir Introduction: Treatment of hidradenitis suppurativa (HS) remains a challenge in clinical practice for dermatologists. Although the efficacy and safety of secukinumab (SEC) in the treatment of HS has been demonstrated in phase III studies, real-world data is limited. Objectives: We conducted a retrospective multicenter study to evaluate the efficacy and safety of SEC treatment in HS patients in real-world settings. Methods: Adult patients who were diagnosed with HS and used SEC for at least 3 months were included in the study. Results: A total of 31 patients were included in the study; 14 of them (45.2%) were female. The mean age was 39.32 ± 10.26 years, and the mean disease duration was 11.77 ± 7.99 years. Nine (29%) patients were biologic-naive and 10 (32.3%) were adalimumab-naive. Disease severity was Hurley I in 7 patients (22.6%), Hurley II in 9 patients (29%), and Hurley III in 15 patients (48.4%). The Hidradenitis Suppurativa Clinical Response (HiSCR) was achieved in 20 patients (64.5%) in the third month of treatment. SEC treatment was discontinued due to primary ineffectiveness in 9 (29%) patients, secondary ineffectiveness in 1 (3.2%) patient, adverse effects in 1 (3.2%) patient, and loss of follow-up in 1 (3.2%) patient. Paradoxical pyoderma gangrenosum was observed as an adverse effect in 1 patient that resolved after discontinuing SEC and starting infliximab. Conclusion: SEC appears to be an effective and safe treatment option for HS, especially when used in the early and mild stages of the disease and in biologic-naive patients. https://dpcj.org/index.php/dpc/article/view/4915secukinumabhidradenitis suppurativareal-world |
| spellingShingle | Ece Erbağcı Özge Sevil Karstarlı Bakay Fatma Aslı Hapa Secukinumab Treatment in Patients With Hidradenitis Suppurativa in Real-World Clinical Settings: A Multicenter Study Dermatology Practical & Conceptual secukinumab hidradenitis suppurativa real-world |
| title | Secukinumab Treatment in Patients With Hidradenitis Suppurativa in Real-World Clinical Settings: A Multicenter Study |
| title_full | Secukinumab Treatment in Patients With Hidradenitis Suppurativa in Real-World Clinical Settings: A Multicenter Study |
| title_fullStr | Secukinumab Treatment in Patients With Hidradenitis Suppurativa in Real-World Clinical Settings: A Multicenter Study |
| title_full_unstemmed | Secukinumab Treatment in Patients With Hidradenitis Suppurativa in Real-World Clinical Settings: A Multicenter Study |
| title_short | Secukinumab Treatment in Patients With Hidradenitis Suppurativa in Real-World Clinical Settings: A Multicenter Study |
| title_sort | secukinumab treatment in patients with hidradenitis suppurativa in real world clinical settings a multicenter study |
| topic | secukinumab hidradenitis suppurativa real-world |
| url | https://dpcj.org/index.php/dpc/article/view/4915 |
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