Antibacterial Activity of Traditional Medicinal Plants Used for the Treatment of Acute Diarrheal Diseases in Chiapas, Mexico
The <i>Enterobacteriaceae</i> family poses health risks due to its role in gastrointestinal diseases like acute diarrhea. With rising antibiotic resistance, plants offer promising antibacterial compounds with low toxicity. This study evaluated the antibacterial activity, minimum inhibito...
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2025-01-01
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| author | Jesús Mauricio Ernesto Hernández-Méndez Israel Peña-Hernández Mariela Tapia-Nazario Gerardo Leyva-Padrón Abumalé Cruz-Salomón María Emperatriz Domínguez-Espinosa Héctor Armando Esquinca-Avilés Maritza del Carmen Hernández-Cruz Rocío Magdalena Sánchez-Albores Kelly del Carmen Cruz-Salomón Rosa Isela Cruz-Rodríguez Martha Guadalupe Gómez-Santos |
| author_facet | Jesús Mauricio Ernesto Hernández-Méndez Israel Peña-Hernández Mariela Tapia-Nazario Gerardo Leyva-Padrón Abumalé Cruz-Salomón María Emperatriz Domínguez-Espinosa Héctor Armando Esquinca-Avilés Maritza del Carmen Hernández-Cruz Rocío Magdalena Sánchez-Albores Kelly del Carmen Cruz-Salomón Rosa Isela Cruz-Rodríguez Martha Guadalupe Gómez-Santos |
| author_sort | Jesús Mauricio Ernesto Hernández-Méndez |
| collection | DOAJ |
| description | The <i>Enterobacteriaceae</i> family poses health risks due to its role in gastrointestinal diseases like acute diarrhea. With rising antibiotic resistance, plants offer promising antibacterial compounds with low toxicity. This study evaluated the antibacterial activity, minimum inhibitory concentration (MIC), and toxicity of ethanolic (EE) and aqueous (AE) extracts from five Mexican medicinal plants traditionally used in Chiapas for treating acute diarrheal diseases (ADD). Antibacterial activity was assessed using disk diffusion assays and MIC determined by macrodilution. Toxicity tests were performed using <i>Artemia salina</i>. As a result, EE extracts exhibited higher antibacterial activity than AE extracts. <i>Byrsonima crassifolia</i> effectively inhibited <i>Salmonella enteritidis</i> (78.26%, MIC 50 mg/mL) and <i>Shigella dysenteriae</i> (76.19%, MIC 25 mg/mL). <i>Solanum torvum</i> showed efficacy against <i>Escherichia coli</i> (55.55%, MIC 12.5 mg/mL) and <i>Salmonella enteritidis</i> (73.91%, MIC 25 mg/mL). <i>Euphorbia maculata</i> inhibited <i>Shigella dysenteriae</i> (104.76%, MIC 25 mg/mL), while <i>Guazuma ulmifolia</i> and <i>Bursera simaruba</i> exhibited no antibacterial effects. All extracts were non-toxic (LD<sub>50</sub> > 1000 μg/mL), indicating potential as natural alternatives for ADD treatment. |
| format | Article |
| id | doaj-art-431f6e99e347493fbeb7bf695d1cbbdd |
| institution | Kabale University |
| issn | 2036-7481 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-431f6e99e347493fbeb7bf695d1cbbdd2025-01-24T13:41:43ZengMDPI AGMicrobiology Research2036-74812025-01-011611010.3390/microbiolres16010010Antibacterial Activity of Traditional Medicinal Plants Used for the Treatment of Acute Diarrheal Diseases in Chiapas, MexicoJesús Mauricio Ernesto Hernández-Méndez0Israel Peña-Hernández1Mariela Tapia-Nazario2Gerardo Leyva-Padrón3Abumalé Cruz-Salomón4María Emperatriz Domínguez-Espinosa5Héctor Armando Esquinca-Avilés6Maritza del Carmen Hernández-Cruz7Rocío Magdalena Sánchez-Albores8Kelly del Carmen Cruz-Salomón9Rosa Isela Cruz-Rodríguez10Martha Guadalupe Gómez-Santos11Escuela de Ciencias Químicas, Universidad Autónoma de Chiapas (UNACH), Ocozocoautla de Espinosa 29140, Chiapas, MexicoDepartamento de Químicos Farmacobiólogos, Universidad Pablo Guardado Chávez (UPGCH), Tuxtla Gutiérrez 29040, Chiapas, MexicoDepartamento de Químicos Farmacobiólogos, Universidad Pablo Guardado Chávez (UPGCH), Tuxtla Gutiérrez 29040, Chiapas, MexicoEscuela de Ciencias Químicas, Universidad Autónoma de Chiapas (UNACH), Ocozocoautla de Espinosa 29140, Chiapas, MexicoEscuela de Ciencias Químicas, Universidad Autónoma de Chiapas (UNACH), Ocozocoautla de Espinosa 29140, Chiapas, MexicoEscuela de Ciencias Químicas, Universidad Autónoma de Chiapas (UNACH), Ocozocoautla de Espinosa 29140, Chiapas, MexicoEscuela de Ciencias Químicas, Universidad Autónoma de Chiapas (UNACH), Ocozocoautla de Espinosa 29140, Chiapas, MexicoEscuela de Ciencias Químicas, Universidad Autónoma de Chiapas (UNACH), Ocozocoautla de Espinosa 29140, Chiapas, MexicoEscuela de Ciencias Químicas, Universidad Autónoma de Chiapas (UNACH), Ocozocoautla de Espinosa 29140, Chiapas, MexicoDivisión de Estudios de Posgrado e Investigación, Tecnológico Nacional de Mexico (TNM) Campus Tuxtla Gutiérrez, Tuxtla Gutiérrez 29050, Chiapas, MexicoDivisión de Estudios de Posgrado e Investigación, Tecnológico Nacional de Mexico (TNM) Campus Tuxtla Gutiérrez, Tuxtla Gutiérrez 29050, Chiapas, MexicoEscuela de Ciencias Químicas, Universidad Autónoma de Chiapas (UNACH), Ocozocoautla de Espinosa 29140, Chiapas, MexicoThe <i>Enterobacteriaceae</i> family poses health risks due to its role in gastrointestinal diseases like acute diarrhea. With rising antibiotic resistance, plants offer promising antibacterial compounds with low toxicity. This study evaluated the antibacterial activity, minimum inhibitory concentration (MIC), and toxicity of ethanolic (EE) and aqueous (AE) extracts from five Mexican medicinal plants traditionally used in Chiapas for treating acute diarrheal diseases (ADD). Antibacterial activity was assessed using disk diffusion assays and MIC determined by macrodilution. Toxicity tests were performed using <i>Artemia salina</i>. As a result, EE extracts exhibited higher antibacterial activity than AE extracts. <i>Byrsonima crassifolia</i> effectively inhibited <i>Salmonella enteritidis</i> (78.26%, MIC 50 mg/mL) and <i>Shigella dysenteriae</i> (76.19%, MIC 25 mg/mL). <i>Solanum torvum</i> showed efficacy against <i>Escherichia coli</i> (55.55%, MIC 12.5 mg/mL) and <i>Salmonella enteritidis</i> (73.91%, MIC 25 mg/mL). <i>Euphorbia maculata</i> inhibited <i>Shigella dysenteriae</i> (104.76%, MIC 25 mg/mL), while <i>Guazuma ulmifolia</i> and <i>Bursera simaruba</i> exhibited no antibacterial effects. All extracts were non-toxic (LD<sub>50</sub> > 1000 μg/mL), indicating potential as natural alternatives for ADD treatment.https://www.mdpi.com/2036-7481/16/1/10acute diarrheaethnobotanyantibacterial activityantibiogram<i>Solanum torvum</i><i>Guazuma ulmifolia</i> |
| spellingShingle | Jesús Mauricio Ernesto Hernández-Méndez Israel Peña-Hernández Mariela Tapia-Nazario Gerardo Leyva-Padrón Abumalé Cruz-Salomón María Emperatriz Domínguez-Espinosa Héctor Armando Esquinca-Avilés Maritza del Carmen Hernández-Cruz Rocío Magdalena Sánchez-Albores Kelly del Carmen Cruz-Salomón Rosa Isela Cruz-Rodríguez Martha Guadalupe Gómez-Santos Antibacterial Activity of Traditional Medicinal Plants Used for the Treatment of Acute Diarrheal Diseases in Chiapas, Mexico Microbiology Research acute diarrhea ethnobotany antibacterial activity antibiogram <i>Solanum torvum</i> <i>Guazuma ulmifolia</i> |
| title | Antibacterial Activity of Traditional Medicinal Plants Used for the Treatment of Acute Diarrheal Diseases in Chiapas, Mexico |
| title_full | Antibacterial Activity of Traditional Medicinal Plants Used for the Treatment of Acute Diarrheal Diseases in Chiapas, Mexico |
| title_fullStr | Antibacterial Activity of Traditional Medicinal Plants Used for the Treatment of Acute Diarrheal Diseases in Chiapas, Mexico |
| title_full_unstemmed | Antibacterial Activity of Traditional Medicinal Plants Used for the Treatment of Acute Diarrheal Diseases in Chiapas, Mexico |
| title_short | Antibacterial Activity of Traditional Medicinal Plants Used for the Treatment of Acute Diarrheal Diseases in Chiapas, Mexico |
| title_sort | antibacterial activity of traditional medicinal plants used for the treatment of acute diarrheal diseases in chiapas mexico |
| topic | acute diarrhea ethnobotany antibacterial activity antibiogram <i>Solanum torvum</i> <i>Guazuma ulmifolia</i> |
| url | https://www.mdpi.com/2036-7481/16/1/10 |
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