Rational application of fructose-1,6-diphosphate: From the perspective of pharmacokinetics
Fructose-1,6-diphosphate (FDP), a glycolytic metabolite, has been reported to protect susceptible organs during hypoxia or ischemia. However, there is paucity of human data on its pharmacokinetics after being exogenously administered. In the current study, the preliminary pharmacokinetics of FDP giv...
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| Format: | Article |
| Language: | English |
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Sciendo
2015-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2015-0020 |
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| author | Li Ting-Ting Xie Jian-Zhong Wang Ling Gao Yang-Yang Jiang Xue-Hua |
| author_facet | Li Ting-Ting Xie Jian-Zhong Wang Ling Gao Yang-Yang Jiang Xue-Hua |
| author_sort | Li Ting-Ting |
| collection | DOAJ |
| description | Fructose-1,6-diphosphate (FDP), a glycolytic metabolite, has been reported to protect susceptible organs during hypoxia or ischemia. However, there is paucity of human data on its pharmacokinetics after being exogenously administered. In the current study, the preliminary pharmacokinetics of FDP given orally to humans was investigated, and no typical peak was observed in the serum drug-time curve. Then, the pharmacokinetic studies were performed following multiple doses of FDP in rats, and the Caco-2 monolayer model was used to study the absorption of FDP in vitro. The results suggested that plasma FDP concentration was significantly increased after oral multiple doses of 180 mg kg-1 but not 90 mg kg-1 of FDP, and FDP was partly depleted during the absorption, which was supposed to be consumed by the intestinal epithelium cells. Thus, we conclude that a high dose of FDP should be orally administered in order to get an effective plasma level. |
| format | Article |
| id | doaj-art-4317c1d8871f4829a596ab5dd400c568 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2015-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-4317c1d8871f4829a596ab5dd400c5682025-02-02T11:59:26ZengSciendoActa Pharmaceutica1846-95582015-06-0165214715710.1515/acph-2015-0020acph-2015-0020Rational application of fructose-1,6-diphosphate: From the perspective of pharmacokineticsLi Ting-Ting0Xie Jian-Zhong1Wang Ling2Gao Yang-Yang3Jiang Xue-Hua4Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University Chengdu, China 2 Pharmacy Department of People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong ChinaPharmacy Department of People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong ChinaKey Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University Chengdu, ChinaKey Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University Chengdu, ChinaKey Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University Chengdu, ChinaFructose-1,6-diphosphate (FDP), a glycolytic metabolite, has been reported to protect susceptible organs during hypoxia or ischemia. However, there is paucity of human data on its pharmacokinetics after being exogenously administered. In the current study, the preliminary pharmacokinetics of FDP given orally to humans was investigated, and no typical peak was observed in the serum drug-time curve. Then, the pharmacokinetic studies were performed following multiple doses of FDP in rats, and the Caco-2 monolayer model was used to study the absorption of FDP in vitro. The results suggested that plasma FDP concentration was significantly increased after oral multiple doses of 180 mg kg-1 but not 90 mg kg-1 of FDP, and FDP was partly depleted during the absorption, which was supposed to be consumed by the intestinal epithelium cells. Thus, we conclude that a high dose of FDP should be orally administered in order to get an effective plasma level.https://doi.org/10.1515/acph-2015-0020fructose-1,6-diphosphateischemiahypoxiapharmacokinetics |
| spellingShingle | Li Ting-Ting Xie Jian-Zhong Wang Ling Gao Yang-Yang Jiang Xue-Hua Rational application of fructose-1,6-diphosphate: From the perspective of pharmacokinetics Acta Pharmaceutica fructose-1,6-diphosphate ischemia hypoxia pharmacokinetics |
| title | Rational application of fructose-1,6-diphosphate: From the perspective of pharmacokinetics |
| title_full | Rational application of fructose-1,6-diphosphate: From the perspective of pharmacokinetics |
| title_fullStr | Rational application of fructose-1,6-diphosphate: From the perspective of pharmacokinetics |
| title_full_unstemmed | Rational application of fructose-1,6-diphosphate: From the perspective of pharmacokinetics |
| title_short | Rational application of fructose-1,6-diphosphate: From the perspective of pharmacokinetics |
| title_sort | rational application of fructose 1 6 diphosphate from the perspective of pharmacokinetics |
| topic | fructose-1,6-diphosphate ischemia hypoxia pharmacokinetics |
| url | https://doi.org/10.1515/acph-2015-0020 |
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